2,8,8-三甲基壬烷-2,7-二醇 | 57512-45-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,8,8-三甲基壬烷-2,7-二醇
• 英文名称: 2,8,8-trimethyl-2,7-nonanediol
• 英文别名: 2,8,8-trimethylnonane-2,7-diol
• CAS: 57512-45-5
• 化学式: C₁₂H₂₆O₂
• 分子量: 202.337
• InChiKey: AMNHLQWCSMTIRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯丁基苯基醚 、 特戊醛 、 丙酮 在 di(tert-butyl)-biphenyl 、 lithium 作用下， 以 四氢呋喃 为溶剂， 反应 2.08h， 以42%的产率得到2,8,8-三甲基壬烷-2,7-二醇
  参考文献：
  名称：

  3-Chloropropyl and 4-Chlorobutyl Phenyl Ethers as Sources of 1,3-Dilithiopropane and 1,4-Dilithiobutane:  Sequential Reaction with Carbonyl Compounds

  摘要：

  The reaction of 3-chloropropyl and 4-chlorobutyl phenyl ethers (1) with lithium powder and a catalytic amount of DTBB (5% molar) in THF at -78 degrees C followed by successive treatment with a carbonyl compound [(RRCO)-R-1-C-2 = (BuCHO)-C-t, Me2CO, (CH2)(5)CO, (-)-menthone] at -78 to 20 degrees C and, after 1.5 h at this temperature, with a second one [(RRCO)-R-3-C-4 = (BuCHO)-C-t, PhCHO, Me2CO, MeCOPrn, (CH2)(5)CO, (-)-menthone] at -78 degrees C leads,after hydrolysis with water, to the corresponding 1,5- and 1,6-diols (2). Because of the competition of two different reductive cleavages, 1,4- and 1,5-diols 3 were also obtained as side-reaction products.

  DOI：

  10.1021/jo000039m

文献信息

• US4006109A
  申请人：——

  公开号：US4006109A

  公开（公告）日：1977-02-01
• [EN] HYALURONIDASE ACTIVITY INHIBITOR<br/>[FR] INHIBITEUR D'ACTIVITÉ HYALURONIDASE<br/>[JA] ヒアルロニダーゼ活性阻害剤
  申请人：ADEKA CORP

  公开号：WO2019142760A1

  公开（公告）日：2019-07-25

  本発明は、幅広い用途に利用可能なヒアルロニダーゼ阻害剤を提供することを目的とする。　本発明は、ヒドロキシ基の一部がカルボキシメチル化されたβ―１，３－１，６－グルカンを含有するヒアルロニダーゼ活性阻害剤である。このヒアルロニダーゼ活性阻害剤は化粧料組成物に対して特に有益である。
• 3-Chloropropyl and 4-Chlorobutyl Phenyl Ethers as Sources of 1,3-Dilithiopropane and 1,4-Dilithiobutane:  Sequential Reaction with Carbonyl Compounds
  作者：Francisco Foubelo、Sadiq A. Saleh、Miguel Yus

  DOI：10.1021/jo000039m

  日期：2000.6.1

  The reaction of 3-chloropropyl and 4-chlorobutyl phenyl ethers (1) with lithium powder and a catalytic amount of DTBB (5% molar) in THF at -78 degrees C followed by successive treatment with a carbonyl compound [(RRCO)-R-1-C-2 = (BuCHO)-C-t, Me2CO, (CH2)(5)CO, (-)-menthone] at -78 to 20 degrees C and, after 1.5 h at this temperature, with a second one [(RRCO)-R-3-C-4 = (BuCHO)-C-t, PhCHO, Me2CO, MeCOPrn, (CH2)(5)CO, (-)-menthone] at -78 degrees C leads,after hydrolysis with water, to the corresponding 1,5- and 1,6-diols (2). Because of the competition of two different reductive cleavages, 1,4- and 1,5-diols 3 were also obtained as side-reaction products.