2-(2,5-二甲基苯基)-1,1,1,3,3,3-六氟-2-丙醇 | 2010-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2,5-二甲基苯基)-1,1,1,3,3,3-六氟-2-丙醇
• 英文名称: 2,5-Dimethyl-1-<2-hydroxy-hexafluor-2-propyl>-benzol
• 英文别名: 2-(2,5-Dimethylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
• CAS: 2010-62-0
• 化学式: C₁₁H₁₀F₆O
• 分子量: 272.19
• InChiKey: OQOULCPVNZYDHV-UHFFFAOYSA-N

物化性质

• 沸点：
  84-86 °C(Press: 20 Torr)
• 密度：
  1.344±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 海关编码：
  2906299090

反应信息

• 作为产物：
  描述：

  对二甲苯 、 六氟丙酮 在 三氯化铝 氮 、 氯仿 、 水 、 magnesium sulfate 作用下， 以 盐酸 为溶剂， 反应 3.0h， 以obtaining 451.3 g of 2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,4-dimethylbenzene的产率得到2-(2,5-二甲基苯基)-1,1,1,3,3,3-六氟-2-丙醇
  参考文献：
  名称：

  Fluorine-containing dicarboxylic acids and their novel polymer compounds

  摘要：

  本文披露了一种含氟二羧酸，其化学式为(1)，其中n表示1-4的整数，两个羧基不相邻于芳环上。通过将含氟二羧酸与共聚物（例如二氨基二醇）反应，可以得到线性聚合物化合物。通过热环化，这种线性聚合物化合物可以转化为具有优异性能的另一种聚合物化合物。

  公开号：

  US08003749B2

文献信息

• [EN] HYPERVALENT RADIOACTIVE ASTATINE OR IODINE COMPOUNDS, AND PREPARATION METHODS THEREOF<br/>[FR] COMPOSÉS HYPERVALENTS D'ASTATINE OU D'IODE RADIOACTIF, ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：INST NAT SANTE RECH MED

  公开号：WO2011095517A1

  公开（公告）日：2011-08-11

  The present invention relates to a compound having formula (I): wherein: - X is in particular 125I Or 211At; - R1 and R'1 are independently from each other chosen preferably from the group consisting of electron-withdrawing groups and alkyl groups; - R2 is chosen from the group consisting of : H, alkyl groups, functional groups being able to bind a vector, and functional groups having targeting properties which make the compound of the invention a vector itself; - Z is a heteroatom, - R5, R8 and R9 are preferably H; - Y is preferably an electron withdrawing group.

  本发明涉及具有以下式（I）的化合物：其中：- X特别是125I或211At；- R1和R'1分别独立地选择自取电子吸引基团和烷基基团的群体中；- R2选择自以下群体：H，烷基基团，能够结合载体的功能基团，以及具有使本发明化合物本身成为载体的靶向性能的功能基团；- Z是杂原子；- R5、R8和R9优选为H；- Y优选为取电子吸引基团。
• NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS
  申请人：Narizuka Satoru

  公开号：US20090030173A1

  公开（公告）日：2009-01-29

  Disclosed is a fluorine-containing dicarboxylic acid represented by formula (1), wherein n represents an integer of 1-4, and the two carboxylic groups are not adjacent to each other on the aromatic ring. It is possible to obtain a linear polymer compound by reacting the fluorine-containing dicarboxylic acid with a comonomer (e.g., diaminodiol). By thermal cyclization, this linear polymer compound can be converted into another polymer compound having superior characteristics.

  本发明公开了一种含氟的二羧酸，其化学式表示为（1），其中n表示1-4的整数，两个羧基不相邻于芳环上。通过将含氟二羧酸与共聚单体（例如，二氨基二醇）反应，可以获得线性聚合物化合物。通过热环化，这种线性聚合物化合物可以转化为具有优异特性的另一种聚合物化合物。
• Fluorine-Containing Dicarboxylic Acids and Their Novel Polymer Compounds
  申请人：NARIZUKA Satoru

  公开号：US20110282026A1

  公开（公告）日：2011-11-17

  A fluorine-containing dicarboxylic acid represented by formula (1), wherein n represents an integer of 1-4, and the two carboxylic groups are not adjacent to each other on the aromatic ring. It is possible to obtain a linear polymer compound by reacting the fluorine-containing dicarboxylic acid with a comonomer (e.g., diaminodiol). By thermal cyclization, this linear polymer compound can be converted into another polymer compound having superior characteristics.

  公式(1)表示的是含氟二羧酸，其中n代表1-4的整数，且两个羧基不相邻于芳香环上。通过将含氟二羧酸与共聚物（例如二氨基二醇）反应，可以得到线性聚合物化合物。通过热环化，这种线性聚合物化合物可以转化为具有卓越特性的另一种聚合物化合物。
• Fluorinated Dicarboxylic Acid Derivative and Polymer Obtained Therefrom
  申请人：Isono Yoshimi

  公开号：US20110301305A1

  公开（公告）日：2011-12-08

  According to the present invention, a polymer is obtained by polycondensation of a fluorinated dicarboxylic acid derivative of the general formula (M-1) or an acid anhydride of the fluorinated dicarboxylic acid with a polyfunctional compound having two to four reactive groups corresponding in reactivity to carbonyl moieties of the fluorinated dicarboxylic acid derivative or acid anhydride. [Chem. 134] AOCF 2 C-Q-CF 2 COA′  (M-1) In the above formula, Q represents a divalent organic group having a substituted or unsubstituted aromatic ring; and A and A′ each independently represent an organic group. This polymer exhibits a sufficiently low dielectric constant for use as a semiconductor protection film and has the capability of forming a film at a relatively low temperature of 250° C. or lower.

  根据本发明，通过将通式(M-1)的含氟二羧酸衍生物或含氟二羧酸酸酐与具有与含氟二羧酸衍生物或酸酐的羰基部分相对应的两到四个反应性基团的多官能化合物进行聚合缩合反应，可以得到一种聚合物。[Chem. 134]AOCF2C-Q-CF2COA′  (M-1)在上述公式中，Q代表具有取代或未取代芳香环的二价有机基团; A和A'各自独立地表示有机基团。该聚合物表现出足够低的介电常数，可用作半导体保护膜，并具有在相对较低的温度下（250℃或更低）形成膜的能力。
• HYPERVALENT RADIOACTIVE ASTATINE OR IODINE COMPOUNDS, AND PREPARATION METHODS THEREOF
  申请人：Gestin Jean-Francois

  公开号：US20130004420A1

  公开（公告）日：2013-01-03

  The present invention relates to a compound having formula (I): wherein: X is in particular 125 I Or 211 At; R 1 and R′ 1 are independently from each other chosen preferably from the group consisting of electron-withdrawing groups and alkyl groups; R 2 is chosen from the group consisting of: H, alkyl groups, functional groups being able to bind a vector, and functional groups having targeting properties which make the compound of the invention a vector itself; Z is a heteroatom, R 5 , R 8 and R 9 are preferably H; Y is preferably an electron withdrawing group.

  本发明涉及一种具有公式（I）的化合物：其中：X特别是125I或211At；R1和R′1独立选择自电子吸引基团和烷基基团的群组，R2选择自H，烷基基团，能够结合载体的功能基团和具有使本发明化合物本身成为载体的靶向性质的功能基团；Z是杂原子，R5，R8和R9优选是H；Y优选是电子吸引基团。