2-(2-吡啶基)乙基硫脲 | 180403-26-3

• 物质功能分类: 化学试剂 - 有机试剂 - 硫脲
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(2-吡啶基)乙基硫脲
• 英文名称: (2-pyridin-2-yl-ethyl)-thiourea
• 英文别名: N-(2-pyridin-2-ylethyl)thiourea；[2-(Pyridin-2-yl)ethyl]thiourea；2-pyridin-2-ylethylthiourea
• CAS: 180403-26-3
• 化学式: C₈H₁₁N₃S
• 分子量: 181.261
• InChiKey: LDLXTZMRWVQZJV-UHFFFAOYSA-N

物化性质

• 熔点：
  93-95°C
• 稳定性/保质期：
  避氧化物

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  6.1
• 安全说明：
  S22,S36/37
• 危险类别码：
  R20/22
• 危险品运输编号：
  UN 2811
• 海关编码：
  2933399090
• 包装等级：
  III
• 危险类别：
  6.1
• 储存条件：
  保存方法：密封于阴凉、通风干燥处。

反应信息

• 作为反应物：
  描述：

  3-溴丙酮酸 、 2-(2-吡啶基)乙基硫脲 在 crude product 作用下， 以 甲醇 为溶剂， 生成 2-(2-pyridin-2-yl-ethylamino)-thiazole-4-carboxylic acid
  参考文献：
  名称：

  SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS

  摘要：

  本发明涉及取代的噻唑-2-基胺衍生物及其药学上可接受的盐，其抑制11βHSD1并可能在调节或抑制11βHSD1有益或需要降低细胞内糖皮质激素水平的疾病治疗中有用。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物治疗此类疾病、疾病或情况，在这些情况中，调节或抑制11βHSD1有益或需要降低细胞内糖皮质激素水平。

  公开号：

  US20120029029A1

文献信息

• Phenylpropanoic acid derivatives
  申请人：Yasuma Tsuneo

  公开号：US20070155808A1

  公开（公告）日：2007-07-05

  The present invention provides a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, a drug for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof have unexpectedly superior GPR40 receptor agonist activity and also show superior properties as a pharmaceutical product, such as stability and the like. Thus, they can be safe and useful drugs for the prophylaxis or treatment of GPR40 receptor related conditions or diseases in mammals.

  本发明提供了一种新型化合物，具有GPR40受体功能调节作用，可用作胰岛素分泌剂，用于预防或治疗糖尿病等药物。化合物由式（I）表示，其中每个符号如规范中所定义，其盐和前药具有意外的优越的GPR40受体激动剂活性，并显示出卓越的药物产品特性，如稳定性等。因此，它们可以作为安全有效的药物，用于哺乳动物中预防或治疗与GPR40受体相关的疾病或病症。
• Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators
  申请人：Polisetti Dharma Rao

  公开号：US08513430B2

  公开（公告）日：2013-08-20

  The present invention is directed to substituted thiazol-2-ylamine derivatives and pharmaceutically acceptable salts thereof that inhibit 11βHSD1 and that may be useful in the treatment of diseases in which modulation or inhibition of 11βHSD1 is beneficial or where a reduction in intracellular glucorticoid levels is desirable. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation or inhibition of 11βHSD1 is beneficial or where a reduction in intracellular glucorticoid levels is desirable.

  本发明涉及取代噻唑-2-胺衍生物及其药学上可接受的盐，其抑制11βHSD1并可用于治疗调节或抑制11βHSD1有益或需要降低细胞内糖皮质激素水平的疾病。本发明还涉及包括这些化合物的制药组合物以及在治疗调节或抑制11βHSD1有益或需要降低细胞内糖皮质激素水平的这些疾病、疾病或病状中使用这些化合物和组合物的用途。
• PHENYLPROPANOIC ACID DERIVATIVES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1698624B1

  公开（公告）日：2012-06-27
• A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries
  作者：Nicholas Bailey、Anthony W. Dean、Duncan B. Judd、David Middlemiss、Richard Storer、Stephen P. Watson

  DOI：10.1016/0960-894x(96)00241-7

  日期：1996.6

  A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries is described. The library preparation is simple, practical, and effective, generating compounds based around a known pharmacophore in high yield and purity. Furthermore, the procedure tolerates a diverse range of functionality in its substrates and is notable in allowing the preparation of compounds containing both free acids and bases without recourse to protection. Copyright (C) 1996 Elsevier Science Ltd
• US7585880B2
  申请人：——

  公开号：US7585880B2

  公开（公告）日：2009-09-08