洛芬扎姆 | 29176-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 中文名称: 洛芬扎姆
• 中文别名: 去甲异安定；洛芬达占
• 英文名称: 8-chloro-1-phenyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one
• 英文别名: 8-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one；Lofendazam；7-chloro-5-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-4-one
• CAS: 29176-29-2
• 化学式: C₁₅H₁₃ClN₂O
• 分子量: 272.734
• InChiKey: IUJQOUHDFKALCY-UHFFFAOYSA-N

物化性质

• 沸点：
  532.1±50.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  洛芬扎姆 、 碘甲烷 在 potassium carbonate 作用下， 生成 8-chloro-5-methyl-1-phenyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one
  参考文献：
  名称：

  Process for preparing 1,5-benzodiazepine-2-ones

  摘要：

  通式为##STR1##的1-芳基-2,3,4,5-四氢-1H-1,5-苯并二氮平-2-酮，其中：R.sub.1是氢，或不饱和的低碳基，优选为1-3个碳，或不饱和的低碳基，优选为2-3个碳；R.sub.2，r.sub.3，r.sub.4，r.sub.5相同或不同，分别是氢，卤素，低碳基，优选为甲基，低烷氧基，优选为甲氧基，或三氟甲基；R.sub.6，r.sub.7，r.sub.8，r.sub.9相同或不同，分别是氢或低碳基，优选为甲基。该化合物通过在溶剂和碱的存在下去卤代2-(3'-卤代丙酰胺基)-二苯胺通式##STR2##，其中R.sub.2至R.sub.9如上定义，X为卤素，使胺环化，然后烷基化以在5位氮上引入不饱和的低碳基R.sub.1，必要时。该化合物具有抗惊厥、镇静和肌肉松弛作用。

  公开号：

  US04108852A1

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF CLOBAZAM AND ITS INTERMEDIATE<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE CLOBAZAM ET SON INTERMÉDIAIRE
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2016151464A1

  公开（公告）日：2016-09-29

  The present invention provides an improved process for the preparation of 8-chloro-1-phenyl- 1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione (hereafter referred to as the compound (IV)), which is useful as a key intermediate for the synthesis of Clobazam (referred to as the compound (I)) 7-chloro-1-methyl-5-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione. The process of the present invention further involves transformation of the compound (IV) into Clobazam (I), comprising (a) reacting the compound (II) (as described herein) with monoalkyl malonate in the presence of a coupling agent to obtain the compound (III) (as described herein); followed by the cyclization using a base; (b) reacting the compound-IV (as described herein) obtained from step (a) with methylating agent. The process of the present invention involves formation of novel intermediates methyl 3-((4- chloro-2-(phenylamino)phenyl)amino)-3-oxopropanoate (IlIa) and 3-((4-chloro-2- (phenylamino)phenyl)amino)-3-oxopropanoic acid (V).

  本发明提供了一种改进的制备8-氯-1-苯基-1H-苯并[b][1,4]二氮杂环-2,4(3H,5H)-二酮（以下简称为化合物（IV））的过程，该过程用作合成氯硝安（简称为化合物（I））7-氯-1-甲基-5-苯基-1H-苯并[b][1,4]二氮杂环-2,4(3H,5H)-二酮的关键中间体。本发明的过程还涉及将化合物（IV）转化为氯硝安（I），包括(a)在偶联剂存在下将化合物（II）（如本文所述）与单烷基马隆酸酯反应，以获得化合物（III）（如本文所述）；随后使用碱进行环化；(b)将从步骤(a)中获得的化合物-IV（如本文所述）与甲基化试剂反应。本发明的过程涉及新型中间体甲基3-((4-氯-2-(苯胺基)苯基)氨基)-3-氧代丙酸酯（IlIa）和3-((4-氯-2-(苯胺基)苯基)氨基)-3-氧代丙酸（V）的形成。
• Calibrachoa plant named ‘Docalhulam’
  申请人：DUMMEN GROUP B.V.

  公开号：USPP030293P2

  公开（公告）日：2019-03-12

  A new and distinct cultivar of Calibrachoa plant named ‘Docalhulam’, characterized by its semi-upright to outwardly spreading, trailing and decumbent plant habit; vigorous growth habit; freely branching habit; early and freely flowering habit; large flowers with purple violet and close to black bi-colored petals; and good garden performance.

  一种新的、独特的Calibrachoa植物品种，名为‘Docalhulam’，其特征为：半直立至向外扩展、垂性和匍匐的植物习性；生长势旺盛；分枝自由；早期和自由开花习性；具有紫色和接近黑色双色花瓣的大花；以及良好的花园表现。
• 1,5'-Benzodiazepine-2-ones, pharmaceutical compositions thereof and
  申请人：Knoll AG

  公开号：US04239684A1

  公开（公告）日：1980-12-16

  1-Aryl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-ones of the general formula ##STR1## wherein: R.sub.1 is hydrogen, lower alkyl, preferably of 1-3 carbons, or unsaturated lower alkyl preferably of 2-3 carbons R.sub.2, R.sub.3, R.sub.4, R.sub.5 are the same or different and are each hydrogen, halogen, lower alkyl, preferably methyl, lower alkoxy, preferably methoxy, or trifluoromethyl, and R.sub.6, R.sub.7, R.sub.8, R.sub.9 are the same or different and are each hydrogen or lower alkyl, preferably methyl. The compounds are prepared by dehydrohalogenating substituted 2-(3'-halogenopropionylamino)-diphenyl amines of the general formula ##STR2## wherein R.sub.2 to R.sub.9 are the same as defined above and X is halogen, in the presence of a solvent and a base, to cyclize the amines and then alkylating to introduce the unsaturated lower alkyl radical R.sub.1 on the nitrogen in the 5 position, if necessary. The compounds possess anticonvulsant, sedative and muscle relaxant properties.

  通式为##STR1##的1-芳基-2,3,4,5-四氢-1H-1,5-苯二氮平-2-酮，其中：R.sub.1为氢，低碳基，优选为1-3碳的低碳基或不饱和的2-3碳的低碳基；R.sub.2、R.sub.3、R.sub.4、R.sub.5相同或不同，分别为氢、卤素、低碳基，优选为甲基的低碳基、低碳氧基，优选为甲氧基或三氟甲基，R.sub.6、R.sub.7、R.sub.8、R.sub.9相同或不同，分别为氢或低碳基，优选为甲基。该化合物通过在溶剂和碱的存在下脱卤化通式为##STR2##的取代2-(3'-卤代丙酰胺基)-二苯胺，其中R.sub.2到R.sub.9如上定义，X为卤素，使胺环化，然后烷基化以在5位氮原子上引入不饱和的低碳基R.sub.1，如果必要的话。该化合物具有抗惊厥、镇静和肌肉松弛作用。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• CD38-BINDING CD31 PEPTIDES AND USES THEREOF
  申请人：ENCEFA

  公开号：EP3943505A1

  公开（公告）日：2022-01-26

  The present invention relates to peptides derived from CD31, specifically binding to CD38; and their use in the prevention and/or treatment of diseases.

  本发明涉及从 CD31 衍生的肽，特别是与 CD38 结合的肽；以及它们在预防和/或治疗疾病中的用途。