2-(2-氯-4-甲基-苯氧基)-乙醇 | 102879-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(2-氯-4-甲基-苯氧基)-乙醇
• 英文名称: 2-(2-chloro-4-methylphenoxy)ethanol
• 英文别名: 2-(2-Chlor-4-methyl-phenoxy)-aethanol；Aethylenglykol-mono-(2-chlor-4-methyl-phenylaether)
• CAS: 102879-15-2
• 化学式: C₉H₁₁ClO₂
• 分子量: 186.638
• InChiKey: UIFZPSBLRQVOIN-UHFFFAOYSA-N

物化性质

• 熔点：
  51-53 °C
• 沸点：
  299.9±25.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-氯-4-甲基-苯氧基)-乙醇 、 isopropyl (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-5’,6’-difluoro-6-methyl-[3,3‘-bipyridin]-5-yl)acetate 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以36.3%的产率得到(S)-isopropyl 2-(tert-butoxy)-2-(6'-(2-(2-chloro-4-methylphenoxy)ethoxy)-4-(4,4-dimethylpiperidin-1-yl)-5'-fluoro-6-methyl-[3,3'-bipyridin]-5-yl)acetate
  参考文献：
  名称：

  [EN] PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  [FR] DÉRIVÉS D'ACIDE PYRIDIN-3-YL-ACÉTIQUE EN TANT QU'INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE

  摘要：

  公开号：

  WO2019244066A3
• 作为产物：
  描述：

  2-氯-4-甲基苯酚 、 2-溴乙醇 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 16.0h， 以69.2%的产率得到2-(2-氯-4-甲基-苯氧基)-乙醇
  参考文献：
  名称：

  [EN] PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  [FR] DÉRIVÉS D'ACIDE PYRIDIN-3-YL-ACÉTIQUE EN TANT QU'INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE

  摘要：

  公开号：

  WO2019244066A3

文献信息

• [EN] 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS<br/>[FR] DERIVES DE 5-(BENZ-(Z)-YLIDENE)-THIAZOLIDINE-4-ONE UTILISES COMME AGENT IMMUNODEPRESSEURS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2005054215A1

  公开（公告）日：2005-06-16

  The invention relates to pharmaceutical compositions containing at least one 5- (benz- (Z) -ylidene-thiazolidin-4-one derivative (I), to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  这项发明涉及含有至少一种5-(苯基(Z)-基噻唑烷酮衍生物(I)的药物组合物，用于预防或治疗与激活的免疫系统相关的疾病。此外，该发明涉及新型噻唑烷酮衍生物，特别用作药用活性化合物。这些化合物特别还作为免疫抑制剂起作用。
• Novel thiazolidin-4-one derivatives
  申请人：Binkert Christoph

  公开号：US20070082933A1

  公开（公告）日：2007-04-12

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及包含至少一种噻唑烷-4-酮衍生物的药物组合物，用于预防或治疗与激活的免疫系统相关的疾病。此外，本发明涉及新型噻唑烷-4-酮衍生物，特别用作药物活性化合物。这些化合物还特别作为免疫抑制剂发挥作用。
• NOVEL THIAZOLIDIN 4-ONE DERIVATIVES
  申请人：Binkert Christoph

  公开号：US20090275625A1

  公开（公告）日：2009-11-05

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及含有至少一种噻唑烷-4-酮衍生物的制药组合物，用于预防或治疗与激活免疫系统相关的疾病。此外，本发明还涉及新的噻唑烷-4-酮衍生物，特别用作药物活性化合物。该化合物还特别作为免疫抑制剂发挥作用。
• NOVEL THIAZOLIDIN-4-ONE DERIVATIVES
  申请人：Binkert Christoph

  公开号：US20080280962A1

  公开（公告）日：2008-11-13

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及含有至少一种噻唑烷-4-酮衍生物的制药组合物，用于预防或治疗与激活免疫系统相关的疾病。此外，本发明还涉及新颖的噻唑烷-4-酮衍生物，特别用于作为药物活性化合物。这些化合物还特别作为免疫抑制剂。
• NOVEL THIAZOLIDIN-4-ONE-DERIVATIVES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：US20130310432A1

  公开（公告）日：2013-11-21

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及含有至少一种噻唑烷-4-酮衍生物的制药组合物，用于预防或治疗与活化免疫系统有关的疾病。此外，本发明还涉及新型噻唑烷-4-酮衍生物，特别用于作为药物活性化合物。这些化合物特别还作为免疫抑制剂。