2-(2-羟基乙基)-6-苯基-3(2H)-吡嗪酮 | 23916-77-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-(2-羟基乙基)-6-苯基-3(2H)-吡嗪酮
• 英文名称: 2-(2-hydroxyethyl)-6-phenyl-3(2H)-pyridazinone
• 英文别名: 2-(2-hydroxy-ethyl)-6-phenyl-2H-pyridazin-3-one；2-[2-(hydroxy)ethyl]-6-phenyl-3(2H)-pyridazinone；2-(2-hydroxyethyl)-6-phenylpyridazin-3(2H)-one；2-(2-Hydroxy-aethyl)-6-phenyl-3(2H)-pyridazinon；1-(2-Hydroxy-aethyl)-3-phenyl-pyridazon-6；3(2H)-Pyridazinone, 2-(2-hydroxyethyl)-6-phenyl-；2-(2-hydroxyethyl)-6-phenylpyridazin-3-one
• CAS: 23916-77-0
• 化学式: C₁₂H₁₂N₂O₂
• mdl: MFCD01692666
• 分子量: 216.239
• InChiKey: XHSYJYUUWKZQOW-UHFFFAOYSA-N

物化性质

• 熔点：
  98-99 °C
• 沸点：
  386.0±44.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-羟基乙基)-6-苯基-3(2H)-吡嗪酮 在 氯化亚砜 、 sodium methylate 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 4.0h， 生成 2-Vinyl-6-phenyl-3-pyridazone
  参考文献：
  名称：

  Vinylation of 3-pyridazones

  摘要：

  DOI：

  10.1007/bf02401732
• 作为产物：
  描述：

  2-(6-Phenylpyridazin-3-yl)oxyethanol 在 PPA 作用下， 反应 5.0h， 以10%的产率得到
  参考文献：
  名称：

  Kosary, Pharmazie, 1993, vol. 48, # 9, p. 700 - 700

  摘要：

  DOI：

文献信息

• Arylpiperazinylalkyl-3(2-H)-pyridazinones
  申请人：FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A.

  公开号：US06413966B1

  公开（公告）日：2002-07-02

  A description is given of new arylpiperazinylalkyl-3(2H)-pyridazinones of general formula (I) and their preparation and their addition salts with pharmaceutically acceptable acids, in which R1 is a methyl or phenyl radical, R2 is a hydrogen atom or a methyl radical, n takes values between 2 and 4, and R3 is a naphthyl radical or a phenyl radical, which are substituted by a radical such as methoxyl, trifluoromethyl and chlorine. The compounds have affinity for serotonin 5HT1A and 5HT2 receptors and for dopamine D2 receptors, and can be useful as antipsychotics.

  给出了一种新的芳基哌嗪基烷基-3（2H）-吡啶嗪酮的描述，其一般式为（I），以及它们的制备和与药学上可接受的酸的加成盐。其中，R1是甲基或苯基基团，R2是氢原子或甲基基团，n取值在2到4之间，R3是萘基基团或苯基基团，它们被甲氧基，三氟甲基和氯等基团取代。这些化合物具有对5HT1A和5HT2受体以及多巴胺D2受体的亲和力，可用作抗精神病药物。
• Nitrogen-Containing heterocyclyl ketones and methods of use
  申请人：Albrecht Brian K.

  公开号：US20080280917A1

  公开（公告）日：2008-11-13

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗HGF介导的疾病等疾病有效。本发明涵盖了新型化合物、类似物、前药和其药学上可接受的盐、制药组合物以及预防和治疗涉及癌症等疾病和其他疾病或病况的方法。本发明还涉及制造这种化合物的过程，以及在这些过程中有用的中间体。
• Nitrogen-containing heterocyclyl ketones and methods of use
  申请人：Amgen Inc.

  公开号：US08314087B2

  公开（公告）日：2012-11-20

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对于预防和治疗诸如HGF介导的疾病等疾病有效。本发明涵盖了新型化合物、类似物、前药及其药学上可接受的盐、制药组合物和预防和治疗涉及癌症等疾病和其他疾病或状况的方法。本发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists
  申请人：FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A.

  公开号：EP1057820A1

  公开（公告）日：2000-12-06

  A description is given of new arylpiperazinylalkyl-3(2H)-pyridazinones of general formula (I) and their preparation and their addition salts with pharmaceutically acceptable acids, in which R1 is a methyl or phenyl radical, R2 is a hydrogen atom or a methyl radical, n takes values between 2 and 4, and R3 is a naphthyl radical or a phenyl radical, which are substituted by a radical such as methoxyl, trifluoromethyl and chlorine. The compounds present affinity for serotonin 5HT1A and 5HT2 receptors and for dopamine D2 receptors, and can be useful as antipsychotics.

  本文介绍了通式(I)的新芳基哌嗪基烷基-3(2H)-哒嗪酮及其制备方法，以及它们与药学上可接受的酸的加成盐、 其中 R1 是甲基或苯基，R2 是氢原子或甲基，n 取值在 2 和 4 之间，R3 是萘基或苯基，它们被甲氧基、三氟甲基和氯等基团取代。 这些化合物对血清素 5HT1A 和 5HT2 受体以及多巴胺 D2 受体具有亲和力，可用作抗精神病药物。
• WO2008/103277
  申请人：——

  公开号：——

  公开（公告）日：——