5-(4-methoxyphenyl)-4-methyl-2-phenyl-3H-1,2,4-triazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-methoxyphenyl)-4-methyl-2-phenyl-3H-1,2,4-triazol-3-one
• 英文别名: 5-(4-Methoxyphenyl)-4-methyl-2-phenyl-1,2,4-triazol-3-one
• 化学式: C₁₆H₁₅N₃O₂
• 分子量: 281.314
• InChiKey: TWTRMRDPHGZDOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones
  申请人：——

  公开号：US20020045651A1

  公开（公告）日：2002-04-18

  A method for treating a neurodegenerative disease or cerebral ischemia arising from conditions selected from the group consisting of Status epilepticus, hypoglycaemia, hypoxia, anoxia, brain trauma, brain oedema, amyotropic lateral sclerosis, Huntington's disease, Alzheimer's disease, hypotonia, cardiac infarction, brain pressure (elevated intracranial pressure), ischaemic and haemorrhagic stroke, global cerebral ischaemia with heart stoppage, diabetic polyneuropathy, tinnitus, perinatal asphyxia, psychosis, schizophrenia, depression, and Parkinson's disease, the method of treatment comprising administering to a host in need of such treatment a therapeutic amount of a compound of formula (I) 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing a compound of formula (I).

  一种治疗由以下病况引起的神经退行性疾病或脑缺血的方法，所述病况包括癫痫持续状态、低血糖、低氧、无氧、脑外伤、脑水肿、肌萎缩性侧索硬化症、亨廷顿病、阿尔茨海默病、低张力、心肌梗塞、脑压力（颅内压增高）、缺血性和出血性中风、全脑缺血伴心脏停顿、糖尿病多发性神经病、耳鸣、围生期窒息、精神病、精神分裂症、抑郁症和帕金森病，所述治疗方法包括向需要该治疗的宿主施用化合物I（式中R1、R2、R3、R4、R5、R6和R7如本文所定义）或其药学上可接受的盐的治疗剂量，以及含有化合物I的药物组合物。
• US6492407B2
  申请人：——

  公开号：US6492407B2

  公开（公告）日：2002-12-10