2-(Benzo[d][1,3]dioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-(3,4,5-trimethoxybenzyl)but-2-enoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(Benzo[d][1,3]dioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-(3,4,5-trimethoxybenzyl)but-2-enoic acid
• 英文别名: (Z)-2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-[(3,4,5-trimethoxyphenyl)methyl]but-2-enoic acid
• 化学式: C₂₈H₂₆O₉
• 分子量: 506.5
• InChiKey: OFCTYBMKKTVKCR-QQTULTPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Therapeutic treatments using centhaquin
  申请人：MIDWESTERN UNIVERSITY

  公开号：US10828368B2

  公开（公告）日：2020-11-10

  Methods of treating hypertension, pain, and resuscitative hemorrhagic shock using an adrenergic agent, like centhaquin, are disclosed. The methods treat mammals, including humans.

  公开了使用肾上腺素能制剂（如仙人掌）治疗高血压、疼痛和抢救失血性休克的方法。这些方法可治疗哺乳动物，包括人类。
• Method and Composition for Potentiating the Antipyretic Action of a Nonopiod Analgesic
  申请人：Gulati Anil

  公开号：US20080207763A1

  公开（公告）日：2008-08-28

  A composition and method of treating fever, and optionally treating pain, is disclosed. The composition and method utilize a nonopioid analgesic and an endothelin antagonist as active agents to treat fever in mammals, including humans. The composition also is useful in the prevention and treatment of stroke and other cardiovascular disorders, like myocardial infarction.
• Method and Composition for Potentiating an Opiate Analgesic
  申请人：Gulati Anil

  公开号：US20100113396A1

  公开（公告）日：2010-05-06

  Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.
• Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin
  申请人：Gulati Anil

  公开号：US20100173872A1

  公开（公告）日：2010-07-08

  A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.
• Method and Composition for Treating Diabetic Ketoacidosis
  申请人：Gulati Anil

  公开号：US20120070513A1

  公开（公告）日：2012-03-22

  Methods of treating diabetic ketoacidosis are disclosed. The methods utilize an endothelin antagonist to treat diabetic ketoacidosis in mammals, including humans.