1-(N,N-diethylaminomethyl)-2-methylimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(N,N-diethylaminomethyl)-2-methylimidazole
• 英文别名: N-ethyl-N-[(2-methylimidazol-1-yl)methyl]ethanamine
• 化学式: C₉H₁₇N₃
• 分子量: 167.254
• InChiKey: SLGRFVIBJLZPGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  21.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP1207160A1

  公开（公告）日：2002-05-22

  Pure 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a pharmaceutically acceptable salt thereof is prepared in a high yield by a simple process which reacts 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one with a 2-methylimidazole derivative in an organic solvent or in a mixture of an organic solvent and water in the presence of a halosilane compound.

  通过在有机溶剂或有机溶剂和水的混合物中，在卤代硅烷化合物存在下，将1,2,3,9-四氢-9-甲基-3-[(2-甲基-1H-咪唑-1-基)甲基]-4H-咔唑-4-酮或其药学上可接受的盐与2-甲基咪唑衍生物反应，可以高产率地制备出来。
• PROCESS FOR THE PREPARATION OF 1,2,3,9-TETRAHYDRO-9-METHYL-3-{(2-METHYL-1H-IMIDAZOL-1-YL)METHYL}-4H-CARBAZOL-4-ONE
  申请人：——

  公开号：US20020061919A1

  公开（公告）日：2002-05-23

  Pure 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or a pharmaceutically acceptable salt thereof is prepared in a high yield by a simple process which reacts 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one with a 2-methylimidazole derivative in an organic solvent or in a mixture of an organic solvent and water in the presence of a halosilane compound.

  通过简单的方法，将1,2,3,9-四氢-9-甲基-3-[(2-甲基-1H-咪唑-1-基)甲基]-4H-咔唑-4-酮或其药学上可接受的盐与有机溶剂或有机溶剂和水的混合物中的2-甲基咪唑衍生物在卤代硅烷化合物的存在下反应，高产率地制备出来。
• US6388091B1
  申请人：——

  公开号：US6388091B1

  公开（公告）日：2002-05-14