2-(3,5-二甲基吡唑-1-基)胍硝酸盐 | 54902-67-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(3,5-二甲基吡唑-1-基)胍硝酸盐
• 英文名称: 1-amidino-3,5-dimethylpyrazole nitrate
• 英文别名: 1-guanyl-3,5-dimethylpyrazole nitrate；3,5-dimethyl-1-guanylpyrazole nitrate；Guanidine, (3,5-dimethyl-1H-pyrazol-1-yl)-, mononitrate；2-(3,5-dimethylpyrazol-1-yl)guanidine;nitric acid
• CAS: 54902-67-9
• 化学式: C₆H₁₁N₅*HNO₃
• 分子量: 216.2
• InChiKey: AVELLUNDPAEEIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.81
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  148
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (+/-)-trans-2-Cyclohexyloxycyclopropylamine 、 2-(3,5-二甲基吡唑-1-基)胍硝酸盐 以 乙醇 为溶剂， 生成 (+/-)-trans-(2-Cyclohexyloxycyclopropyl)guanidine
  参考文献：
  名称：

  反式-2-环己基氧基环丙胺及其衍生物的合成。

  摘要：

  DOI：

  10.1021/jm00321a012

文献信息

• Synthesis and Inhibitory Activities against Aminopeptidase B and Enkephalin-Degrading Enzymes of Ketomethylene Dipeptide Analogues of Arphamenines
  作者：M. Teresa Garcia-López、Rosario González-Muniz、Juan R. Hartoa、Isabel Gómez-Monterrey、Concepción Pérez、Maria L. De Ceballos、Ester López、Joaquin Del Rio

  DOI：10.1002/ardp.19923250103

  日期：——

  subsequent deprotection of Z‐(S)Pheψ(COCH2)(R,S)Om. The inhibitory effects of compounds 14, 15, 19, and 22, and the related ketomethylene dipeptides (S)Alaψ(COCH2)(R,S)Phe (3), (S)Pheψ(COCH2)(R,S)X [X=Ala (4), Orn (5)] and (S)Trpψ(COCH2)R,S)Y [Y=Orn (6), Lys (7), Arg (8)] on aminopeptidase B (AP‐B), and enkephalin‐degrading enzymes [aminopeptidase N (APN) and neutral endopeptidase (NEP)] were compared

  天然arphamenine A [(S)Argψ 的三种酮亚甲基伪二肽类似物 [(S)Lysψ(COCH2)(R 和 S)Phe (14 或 15 和 15 或 14) 和 (S)Lysψ(COCH2)(ζTrp (19)] (COCH2(R,S)Phe (1)] 很容易通过涉及两个连续主要反应的路线制备：丙二酸酯烷基化与 Z 保护的赖氨酸碘甲基酮和苄基或（吲哚-3-基）甲基的引入生成的 4-酮二酯的 2 位部分。具有反向序列的 1 的异构体，(S)Pheψ(COCH2)(R,S)Arg (22) 通过胍基化和随后的 Z-(S)Pheψ( COCH2)(R,S)Om. 化合物 14、15、19 和 22 以及相关酮亚甲基二肽 (S)Alaψ(COCH2)(R,S)Phe (3)、(S)Pheψ( COCH2)(R,S)X [X=Ala (4), Orn (5)] 和 (S)Trpψ(COCH2)R
• Synthesis of cis- and trans-2-Phenoxycyclopropylamines and Related Compounds
  作者：Jacob Finkelstein、Elliot Chiang、John Lee

  DOI：10.1021/jm00328a005

  日期：1965.7
• Novel Thiazole-Based Heterocycles as Selective Inhibitors of Fibrinogen-Mediated Platelet Aggregation
  作者：Pauline J. Sanfilippo、Patricia Andrade-Gordon、Maud J. Urbanski、Kimberly N. Beers、Annette Eckardt、Robert Falotico、Mark H. Ginsberg、Steve Offord、Jeffrey B. Press

  DOI：10.1021/jm00001a008

  日期：1995.1

  The synthesis and biological activity of novel thiazole-based heterocycles as inhibitors of thrombin-induced human platelet aggregation are described. Further evaluation of selected compounds show they inhibit platelet aggregation as stimulated by a variety of agonists. The more active compounds also were found to inhibit fibrinogen binding to platelets. To further delineate the mechanism of action of these compounds, direct binding studies with the purified glycoprotein (GP) IIb/IIIa receptor were performed. Flow cytometry analyses of 24 and 32 indicate that these compounds block the activation process of the GPIIb/IIIa receptor without denaturing the integrin receptor. On the basis of these studies, 32 exhibited the best profile as a novel nonpeptide inhibitor of fibrinogen-mediated platelet aggregation.
• BRIMBLE, MARGARET A.;ROWAN, DARYL D., J. CHEM. SOC. PERKIN TRANS. PT 1,(1990) N, C. 311-314
  作者：BRIMBLE, MARGARET A.、ROWAN, DARYL D.

  DOI：——

  日期：——
• Crystal and molecular structure of diaqua-bis-(3,5-dimethyl-1-guanyl pyrazole) nickel (II) nitrate, [Ni(C6N4H10)2(H2O)2](N03)2
  作者：A. Podder、B. P. Mukhopadhyay、N. Saha、A. Saha、B. Stensland

  DOI：10.1007/bf01160844

  日期：1989.2