2-[4-(5-Chlorothiophen-2-yl)-2-(4-fluorophenyl)-1,3-oxazol-5-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(5-Chlorothiophen-2-yl)-2-(4-fluorophenyl)-1,3-oxazol-5-yl]acetic acid
• 化学式: C₁₅H₉ClFNO₃S
• 分子量: 337.8
• InChiKey: RLUXUNHKXOTXGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  91.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Large conductance calcium-activated k channel opener
  申请人：——

  公开号：US20040127527A1

  公开（公告）日：2004-07-01

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): 1 wherein X represents N—R 4 , O or S, R 1 and R 2 each independently represent hydrogen, halogen, carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R 3 represents aryl, heterocyclic or lower alkyl group, and R 4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof.

  一种大导电性钙激活的K通道开放剂，包括以下式子（I）所表示的含氮5元杂环化合物作为活性成分：1其中，X代表N-R4，O或S，R1和R2各自独立地代表氢、卤素、羧基、氨基、低级烷基、低级烷氧羰基、低级烯基、环状低级烷基、氨基甲酰基、芳香族、杂环或杂环取代的羰基基团，R3代表芳香族、杂环或低级烷基基团，R4代表氢或低级烷基基团，或其药学上可接受的盐。
• LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER
  申请人：Hongu Mitsuya

  公开号：US20100256165A1

  公开（公告）日：2010-10-07

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents N—R 4 , O or S, R 1 and R 2 each independently represent hydrogen, halogen, carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R 3 represents aryl, heterocyclic or lower alkyl group, and R 4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof.

  一种大导电性钙激活的K通道开放剂，其作为活性成分是一种含氮的5元杂环化合物，表示为以下式子（I）：其中X代表N—R4，O或S，R1和R2各自独立地表示氢、卤素、羧基、氨基、低碳基、低碳氧基羰基、低烯基、环-低碳基、氨基甲酰基、芳基、杂环或杂环取代的羰基基团，R3表示芳基、杂环或低碳基团，R4表示氢或低碳基团，或其药学上可接受的盐。
• IMIDAZOLE, THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF POLLAKIURIA OR URINARY INCONTINENCE
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP1432690A2

  公开（公告）日：2004-06-30
• US7759373B2
  申请人：——

  公开号：US7759373B2

  公开（公告）日：2010-07-20
• [EN] LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER<br/>[FR] SUBSTANCE D'OUVERTURE DU CANAL K ACTIVEE PAR LE CALCIUM A GRANDE CONDUCTANCE
  申请人：TANABE SEIYAKU CO

  公开号：WO2002083111A2

  公开（公告）日：2002-10-24

  A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents N-R4, O or S, R1 and R 2 each independently represent hydrogen, halogen carboxyl, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, cyclo-lower alkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl group, R3 represents aryl, heterocyclic or lower alkyl group, and R4 represents hydrogen or lower alkyl group, or a pharmaceutically acceptable salt thereof and its use for the preparation of a medicament for the phophylaxis and/or treatment of pollakiuria or urinary incontinence.