2-(3-乙烯基苯基)乙腈 | 110013-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3-乙烯基苯基)乙腈
• 英文名称: m-vinylphenylacetonitrile
• 英文别名: 2-(3-Ethenylphenyl)acetonitrile
• CAS: 110013-89-3
• 化学式: C₁₀H₉N
• mdl: MFCD09923662
• 分子量: 143.188
• InChiKey: VBRWJLQEFUANAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-乙烯基苯基)乙腈 在 copper acetylacetonate 、 水 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 15.08h， 生成 rac-(1R,2R)-2-(3-(cyanomethyl)phenyl)cyclopropane-1-carboxylic acid
  参考文献：
  名称：

  [EN] INDOLE COMPOUNDS AND METHODS OF USE
  [FR] COMPOSÉS INDOLES ET PROCÉDÉS D'UTILISATION

  摘要：

  The invention relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

  公开号：

  WO2023034992A1
• 作为产物：
  描述：

  3-溴氰苄 、 乙烯基硼酸频哪醇酯 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以78 %的产率得到2-(3-乙烯基苯基)乙腈
  参考文献：
  名称：

  [EN] INDOLE COMPOUNDS AND METHODS OF USE
  [FR] COMPOSÉS INDOLES ET PROCÉDÉS D'UTILISATION

  摘要：

  The invention relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

  公开号：

  WO2023034992A1

文献信息

• A versatile scaffold for facile synthesis of fluorescent cyano-substituted stilbenes
  作者：Shotaro Hayashi、Minami Sakamoto、Fumitaka Ishiwari、Takanori Fukushima、Shin-ichi Yamamoto、Toshio Koizumi

  DOI：10.1016/j.tet.2019.01.012

  日期：2019.2

  Here we report the facile derivatization of a cyano-substituted stilbene into higher π-extended analogues. The cyano-substituted stilbene, which serves as a synthetic scaffold, has a bromo group and a formyl group on its 4- and 4′-position of the phenylene rings and thus readily undergoes selective transformation into other functional groups using various simple organic reactions. The resultant π-conjugated

  在这里，我们报道了氰基取代的二苯乙烯容易被衍生为更高的π-延伸的类似物。用作合成支架的氰基取代的二苯乙烯在亚苯基环的4和4'位置具有一个溴基和一个甲酰基，因此可以使用各种简单的有机反应轻松地选择性转化为其他官能团。所得的包含氰基取代的二苯乙烯骨架的π共轭分子在溶液中和固态时均显示出荧光。
• Polymerizable composition, optical material comprising the composition and method for producing the material
  申请人：——

  公开号：US20040254258A1

  公开（公告）日：2004-12-16

  A cured matter obtained by polymerizing and curing a polymerizable composition comprising a compound having at least one episulfide in a molecule is reduced in an odor by adding a perfume to the polymerizable composition comprising the compound having at least one episulfide in a molecule. A cloudiness of the lens is removed by raising a purity of sulfur to 98% or more. A reduction in a chlorine content of the sulfur compound described above to 0.1% by weight or less elevates an oxidation resistance and a light fastness of the high refractive index optical material and improves a color tone thereof. An optical product having a high refractive index and a high-degree transparency is provided by subjecting the composition in advance to deaerating treatment at 0 to 100° C. for one minute to 24 hours under a reduced pressure of 0.001 to 50 torr.

  通过聚合和固化至少含有一种环硫醚的化合物的可聚合组合物获得的治愈物质，通过向至少含有一种环硫醚的化合物的可聚合组合物中添加香水来减少其气味。通过将硫的纯度提高到98％或更高，可以消除镜片的混浊。将上述硫化合物的氯含量降低至0.1％或更低可以提高高折射率光学材料的氧化抗性和耐光性，并改善其色调。通过在0至100°C下将组合物事先进行脱气处理，以在0.001至50 torr的减压下持续1分钟至24小时，可提供具有高折射率和高度透明度的光学产品。
• COMPOSITION FOR OPTICAL MATERIAL
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP1319966A1

  公开（公告）日：2003-06-18

  The composition for optical materials of the present invention contains at least one compound represented by the following Formula 1: wherein R1, R2 and R3 are each independently C1-C10 hydrocarbyl or hydrogen; X1, X2 and X3 are each independently S, Se or Te; Y1, Y2 and Y3 are each independently -Sa-[(CH2)bS]cH, a is an integer from 0 to 2, b is an integer from 0 to 4, and c is an integer from 0 to 2, and a compound reactive to the compound of Formula 1. A resin produced by curing a composition containing the compound of Formula 1 by polymerization has a high refractive index, and suitable as various optical materials.

  本发明的光学材料组合物含有至少一种由下式 1 表示的化合物： 其中R1、R2和R3各自独立地为C1-C10烃基或氢；X1、X2和X3各自独立地为S、Se或Te；Y1、Y2和Y3各自独立地为-Sa-[(CH2)bS]cH，a为0至2的整数，b为0至4的整数，c为0至2的整数，以及与式1化合物反应的化合物。通过聚合固化含有式 1 化合物的组合物而产生的树脂具有高折射率，适合用作各种光学材料。
• POLYMERIZABLE COMPOSITION, OPTICAL MATERIAL COMPRISING THE COMPOSITION AND METHOD FOR PRODUCING THE MATERIAL
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP1524289A1

  公开（公告）日：2005-04-20

  A cured matter obtained by polymerizing and curing a polymerizable composition comprising a compound having at least one episulfide in a molecule is reduced in an odor by adding a perfume to the polymerizable composition comprising the compound having at least one episulfide in a molecule. A cloudiness of the lens is removed by raising a purity of sulfur to 98 % or more. A reduction in a chlorine content of the sulfur compound described above to 0.1 % by weight or less elevates an oxidation resistance and a light fastness of the high refractive index optical material and improves a color tone thereof. An optical product having a high refractive index and a high-degree transparency is provided by subjecting the composition in advance to deaerating treatment at 0 to 100°C for one minute to 24 hours under a reduced pressure of 0.001 to 50 torr.

  通过聚合和固化包含分子中至少含有一种表硫化物的化合物的可聚合组合物而获得的固化物，可通过向包含分子中至少含有一种表硫化物的化合物的可聚合组合物中添加香料来减少气味。 将硫的纯度提高到 98% 或更高，可消除镜片的浑浊度。 将上述硫化合物的氯含量降低到 0.1%（重量百分比）或更低，可提高高折射率光学材料的抗氧化性和耐光性，并改善其色调。 在 0.001 至 50 托的减压条件下，将组合物预先在 0 至 100°C 的温度下进行 1 分钟至 24 小时的脱气处理，可获得具有高折射率和高透明度的光学产品。
• CURABLE COMPOSITION
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP1882713A1

  公开（公告）日：2008-01-30

  A curable composition containing an inorganic compound A having sulfur atom and/or selenium atom, a compound B represented by the following formula 1: wherein m is an integer from 0 to 4, and n is an integer from 0 to 2, and a compound C selected from the group consisting of thiol compounds having one SH group and disulfide compounds which are other than the compound B and have one or more disulfide linkages. The inorganic compound A is contained in an amount from 1 to 50 parts by weight and the compound B is contained in an amount from 50 to 99 parts by weight when a total of the inorganic compound A and the compound B is taken as 100 parts by weight. The compound C is contained in an amount from 1 to 20 parts by weight based on 100 parts by weight in total of the inorganic compound A and the compound B. The curable composition causes little increase in the viscosity even when subjected to prepolymerization and deaeration, thereby facilitating the operation of cast polymerization for producing optical materials, etc.

  一种可固化组合物，含有一种具有硫原子和/或硒原子的无机化合物 A，一种由下式 1 表示的化合物 B： 其中 m 为 0 至 4 的整数，n 为 0 至 2 的整数，以及选自具有一个 SH 基团的硫醇化合物和二硫化合 物的化合物 C，该化合物与化合物 B 不同，具有一个或多个二硫键。无机化合物 A 的含量为 1 至 50 份（按重量计），化合物 B 的含量为 50 至 99 份（按重量计），当无机化合物 A 和化合物 B 的总量为 100 份（按重量计）时。以无机化合物 A 和化合物 B 的总重量为 100 重量份计，化合物 C 的含量为 1 至 20 重量份。该可固化组合物即使在进行预聚合和脱气时，粘度也几乎不会增加，因此有利于生产光学材料等的浇铸聚合操作。

表征谱图