cis-[bis(methylamino)bis(nitrato)platinum(II)] | 215243-42-8

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: cis-[bis(methylamino)bis(nitrato)platinum(II)]
• 英文别名: cis-Pt(MeNH2)2(NO3)2；cis-[platinum(II)(methylamine)2(nitrate)2]；cis-Pt(methylamine)2(nitrate)2；Methanamine;platinum(2+);dinitrate
• CAS: 215243-42-8；719297-31-1；61593-74-6
• 化学式: C₂H₁₀N₄O₆Pt
• 分子量: 381.205
• InChiKey: GXVMQDRRORWTNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.33
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  178
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  cis-[bis(methylamino)bis(nitrato)platinum(II)] 在 盐酸 作用下， 以 水 为溶剂， 生成 cis-[platinum(II)bis(methylamine)dichloride]
  参考文献：
  名称：

  SYNTHESIS OF (GLYCOLATO-O,O′)DIAMMINEPLATINUM(II) AND ITS RELATED COMPLEXES

  摘要：

  甘醇酸合铂(II)配合物[Pt(OCOCH2O)L2]是一种具有新型五元环结构的化合物，通过将甘醇酸与水合顺式-[Pt(OH)2L2]（L：NH3、胺）等摩尔比混合并在水中加热制得。这些配合物也可通过顺式-[Pt(NO3)2L2]与甘醇酸钠在中性水溶液中反应生成。通过二次离子质谱、红外光谱和核磁共振波谱技术对这些配合物进行了表征。

  DOI：

  10.1246/cl.1986.429
• 作为产物：
  描述：

  cis-diiodobis(methylamine)platinum(II) 在 silver nitrate 作用下， 以 丙酮 为溶剂， 以85%的产率得到cis-[bis(methylamino)bis(nitrato)platinum(II)]
  参考文献：
  名称：

  快速合成水溶性铂（II）胺和吡啶配合物的方法

  摘要：

  十七顺- [PT（AM）2（ONO 2）2 ]配合物（AM =甲胺，环烷基，取代的吡啶，苯胺，苄胺或;上午02点= 2,2'-联吡啶），通过反应合成顺式- [铂（ am）2 l 2 ]，用硝酸银的丙酮溶液。反应迅速（室温下5–20分钟），产率约85％。相对于异构化，该络合物在丙酮中似乎是稳定的。因此，在25°C下1小时后，顺式-[Pt（am）2 X 2 ]（am =环己胺或4-甲基吡啶； X = I或ONO 2）的丙酮溶液显示1没有判断异构化。这些化合物及其相应的反式异构体的1 H nmr光谱。

  DOI：

  10.1039/dt9900000307

文献信息

• SYNTHESIS OF (GLYCOLATO-<i>O</i>,<i>O</i>′)DIAMMINEPLATINUM(II) AND ITS RELATED COMPLEXES
  作者：Tetsushi Totani、Katsutoshi Aono、Michihiro Komura、Yasuko Adachi

  DOI：10.1246/cl.1986.429

  日期：1986.3.5

  Glycolatoplatinum(II) complexes, [Pt(OCOCH2O)L2], having a novel five-membered ring structure were obtained by adding an equimolar quantity of glycolic acid to cis-[Pt(OH)2L2] (L: NH3, amines) in water followed by heating. These complexes have also been obtained by reaction of cis-[Pt(NO3)2L2] with sodium glycolate in neutral aqueous solution. These complexes have been characterized by SIMS, IR, and NMR spectroscopy.

  甘醇酸合铂(II)配合物[Pt(OCOCH2O)L2]是一种具有新型五元环结构的化合物，通过将甘醇酸与水合顺式-[Pt(OH)2L2]（L：NH3、胺）等摩尔比混合并在水中加热制得。这些配合物也可通过顺式-[Pt(NO3)2L2]与甘醇酸钠在中性水溶液中反应生成。通过二次离子质谱、红外光谱和核磁共振波谱技术对这些配合物进行了表征。
• Synthesis, IR, and multinuclear NMR spectroscopic studies of complexes of the type <i>cis</i>- and <i>trans</i>-Pt(amine)₂(NO₃)₂
  作者：Fernande D Rochon、Viorel Buculei

  DOI：10.1139/v04-012

  日期：2004.4.1

  Compounds of the types cis- and trans-Pt(amine)₂NO₃)₂ have been synthesized and characterized by IR and multinuclear (¹⁹⁵Pt, ¹³C, and ¹H) NMR spectroscopies. The nitrato IR bands were compared for the two isomers. The ¹⁹⁵Pt NMR resonances of the trans complexes were observed at lower fields (avg. –1570 ppm for primary amines) than the cis analogues (avg. –1698 ppm) for an average Δδ value of 124 ppm. The complexes containing a secondary amine were observed at about the same field for the cis isomers (avg. –1682 ppm) and surprisingly at much higher fields for the trans compounds (avg. –1638 ppm). In ¹H NMR, the coupling constants ²J(¹⁹⁵Pt-¹HN) are larger for the cis isomers (avg. 67 Hz) than for the trans compounds (avg. 58 Hz). The ³J(¹⁹⁵Pt-¹H) are also larger for the cis complexes (avg. 40 vs. 33 Hz). In ¹³C NMR, the coupling constants are also geometry dependent. The ³J(¹⁹⁵Pt-¹³C) are larger for the cis isomers (avg. 37 Hz) than for the trans compounds (avg. 28 Hz). The ²J(¹⁹⁵Pt-¹³C) are much smaller (avg. 18 Hz for the cis complexes and 16 Hz for the trans isomers).Key words: platinum, amine, nitrato, NMR, IR.

  已合成并通过红外和多核（¹⁹⁵Pt，¹³C和¹H）核磁共振光谱表征了cis-和trans-Pt（amine）₂NO₃)₂ 类型的化合物。比较了两种异构体的硝酸盐红外带。观察到trans配合物的¹⁹⁵Pt NMR共振在较低场（对于主要胺平均为–1570 ppm）而cis类似物的共振在较高场（平均–1698 ppm），平均Δδ值为124 ppm。对于含有次要胺的配合物，cis异构体的场与trans类似物相同（平均–1682 ppm），但令人惊讶的是trans化合物的场要高得多（平均–1638 ppm）。在¹H NMR中，偶合常数²J（¹⁹⁵Pt-¹HN）对于cis异构体（平均67 Hz）大于对于trans化合物（平均58 Hz）。³J（¹⁹⁵Pt-¹H）也对于cis配合物（平均40 vs 33 Hz）更大。在¹³C NMR中，偶合常数也与几何构型有关。³J（¹⁹⁵Pt-¹³C）对于cis异构体（平均37 Hz）大于对于trans化合物（平均28 Hz）。²J（¹⁹⁵Pt-¹³C）要小得多（cis配合物平均18 Hz，trans异构体平均16 Hz）。关键词：铂，胺，硝酸盐，核磁共振，红外。
• Multinuclear magnetic resonance studies of the aqueous products of the complexes <i>cis</i>- and <i>trans</i>-Pt(amine)₂(NO₃)₂
  作者：Fernande D Rochon、Viorel Buculei

  DOI：10.1139/v04-121

  日期：2004.11.1

  The hydrolyis or the aquation reactions of the compounds cis- and trans-Pt(amine)₂(NO₃)₂ were studied in D₂O in different conditions of pH. The products were characterized by multinuclear (¹⁹⁵Pt, ¹³C, and ¹H) magnetic resonance spectroscopy. In acidic medium, the product was [Pt(amine)₂(D₂O₂)]²⁺ and for a few amines, trans- [Pt(amine)₂(D₂O)(NO₃)]⁺ was detected. The ¹⁹⁵Pt NMR resonances of the diaqua complexes were observed at higher fields for the cis compounds (avg. –1727 ppm) than for the trans isomers (avg. –1560 ppm). At basic pH, Pt(amine)₂(OD)₂ was formed and for ethylamine, trans-Pt(EtNH₂)₂(OD)(NO₃) was detected. The cis compounds were also observed at higher fields than the trans isomers (–1706 ppm vs. –1574 ppm). The coupling constants with ¹⁹⁵Pt were geometry dependent. The avg. ²J(¹⁹⁵Pt-¹H) values for the diaqua species were 66 (cis) and 57 (trans) Hz, while the avg. ³J(¹⁹⁵Pt-¹H) were 43 (cis) and 34 (trans) Hz for the diaqua compounds, and 43 and 37 Hz, respectively, for the dihydroxo species. The ²J(¹⁹⁵Pt-¹³C) avg. values were 18 (cis) and 12 (trans) Hz and the avg. ³J(¹⁹⁵Pt-¹³C) were 31 (cis) and 23 (trans) Hz for both the diaqua and dihydroxo compounds. For the cis isomers, at neutral pH, the monoaqua–monohydroxo species (avg. –1721 ppm) and the dihydroxo-bridged dimer (avg. –1353 ppm) were observed. For a few amines, the monohydroxo-bridged dimer was observed (avg. –1684 ppm) and its concentration increased with time. For the trans compounds, the monoaqua–monohydroxo species was observed at –1563 ppm (avg.). For a few amines, the hydroxo-bridged dimer was present. For methylamine, a third species assigned to a higher oligomer was observed after 6 months.Key words: platinum, amine, nitrato, hydrolysis, NMR, aquation.

  研究了在不同pH条件下，cis-和trans-Pt(amine)₂(NO₃)₂化合物的水解或水合反应在D₂O中的情况。通过多核磁共振光谱（¹⁹⁵Pt，¹³C和¹H）对产物进行了表征。在酸性介质中，产物为[Pt(amine)₂(D₂O₂)]²⁺，对于一些胺类，检测到trans-[Pt(amine)₂(D₂O)(NO₃)]⁺。对于cis化合物，二水合物的¹⁹⁵Pt NMR共振在高场（平均为-1727 ppm）上观察到，而trans异构体的平均值为-1560 ppm。在碱性pH下，形成了Pt(amine)₂(OD)₂，对于乙胺，检测到trans-Pt(EtNH₂)₂(OD)(NO₃)。cis化合物也观察到比trans异构体更高的场（-1706 ppm vs. -1574 ppm）。与¹⁹⁵Pt的耦合常数与几何形状相关。二水合物种的平均²J (¹⁹⁵Pt-¹H)值为66（cis）和57（trans）Hz，而二水合物种的平均³J (¹⁹⁵Pt-¹H)值分别为43（cis）和34（trans）Hz，二羟基物种的值分别为43和37 Hz。²J (¹⁹⁵Pt-¹³C)平均值为18（cis）和12（trans）Hz，而³J (¹⁹⁵Pt-¹³C)平均值为31（cis）和23（trans）Hz，适用于二水合物种和二羟基物种。对于cis异构体，在中性pH下，观察到单水合单羟基物种（平均为-1721 ppm）和二羟基桥联二聚体（平均为-1353 ppm）。对于一些胺类，观察到单羟基桥联二聚体（平均为-1684 ppm），其浓度随时间增加。对于trans化合物，在-1563 ppm（平均）观察到单水合单羟基物种。对于甲胺，观察到第三个被指定为更高寡聚体的物种，经过6个月后出现。关键词：铂，胺，硝酸盐，水解，NMR，水合作用。
• Synthesis and multinuclear magnetic resonance spectroscopy of the novel ionic Pt(II) mixed-ligands complexes cis- and trans-[Pt(amine)2(pyrimidine)2](NO3)2
  作者：Fernande D. Rochon、Hyem Titouna、Laurence Piche

  DOI：10.1016/j.ica.2010.01.001

  日期：2010.5

  Novel ionic mixed-ligands complexes of the types cis- and trans-[Pt(amine)(2)(pm)(2)](NO3)(2) (where pm = pyrimidine) were synthesized and studied in the solid state by IR spectroscopy and in aqueous solution by multinuclear (Pt-195, H-1 and C-13) magnetic resonance spectroscopy. The results of the solution NMR characterization have shown that the isolated compounds are pure. In Pt-195 NMR, the cis RNH2 complexes were observed at slightly lower fields (ave.-2441 ppm) than the equivalent trans analogues (ave.-2448 ppm). For Me2NH, the difference between the two isomers is larger (29 ppm). The complexes are observed at lower fields (difference of 100 ppm) than the corresponding [Pt(amine)(4)](2+) complexes, which might indicate the presence of pi-backdonation in the Pt-pm bond. In H-1 NMR, the coupling constants (3)J(Pt-195-H-1(amine)) are larger in the cis compounds (38-48 Hz) than in the trans analogues (30-36 Hz). The (3)J(Pt-195-H-1(pm)) values are also larger for the cis isomers. In C-13 NMR spectroscopy, the coupling constants (3)J(Pt-195-C-13(amine)) are 36 Hz (ave.) for the cis complexes and 26 Hz (ave.) for the trans isomers, while the (2)J(Pt-195-C-13(amine)) are 18 Hz (cis) and 14 Hz (trans), respectively. The (3)J(Pt-195-C-13(5(pm))) values are 36 Hz (cis) and 28 Hz (trans). A few (2)J(Pt-195-C-13(pm)) couplings were observed (7-10 Hz). (C) 2010 Elsevier B.V. All rights reserved.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 117, page 266 - 268
  作者：

  DOI：——

  日期：——