4-Phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-amine | 148611-84-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-amine
• 英文别名: 4-phenyl-5-pyridin-4-yl-1H-pyrazol-3-amine
• CAS: 148611-84-1
• 化学式: C₁₄H₁₂N₄
• mdl: MFCD09971983
• 分子量: 236.27
• InChiKey: FIYOMWDWUASSIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Inhibitors of cellular metabolic processes
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US10329298B2

  公开（公告）日：2019-06-25

  The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA): wherein RA, RB, RC, RD, and RE are defined herein.

  本公开提供了可作为治疗剂用于治疗恶性肿瘤的 MAT2A 抑制剂化合物，其中的化合物符合通式 (IA)： 其中 RA、RB、RC、RD 和 RE 在本文中定义。
• INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1435957A2

  公开（公告）日：2004-07-14
• EP1435957A4
  申请人：——

  公开号：EP1435957A4

  公开（公告）日：2005-04-13
• INHIBITORS OF CELLULAR METABOLIC PROCESSES
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20180079753A1

  公开（公告）日：2018-03-22

  The present disclosure provides MAT2A inhibitor compounds that are useful as therapeutic agents for treating malignancies, and wherein the compounds conform to general formula (IA): wherein R A , R B , R C , R D , and R E are defined herein.
• [EN] INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3 beta PROTEIN AND PROTEIN COMPLEXES<br/>[FR] INHIBITEURS DE GSK-3 ET STRUCTURES CRISTALLINES DE LA PROTEINE GSK-3 beta ET DE COMPLEXES PROTEIQUES
  申请人：VERTEX PHARMA

  公开号：WO2002088078A2

  公开（公告）日：2002-11-07

  The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.