N-(2-bromo-1-phenylethyl)butanamide | 1133160-11-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-bromo-1-phenylethyl)butanamide
• CAS: 1133160-11-8
• 化学式: C₁₂H₁₆BrNO
• 分子量: 270.169
• InChiKey: GUKGBFLGNWQDIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙烯 、 丁腈 在 N-溴代丁二酰亚胺(NBS) 、 indium(III) bromide 、 水 作用下， 反应 0.42h， 以80%的产率得到N-(2-bromo-1-phenylethyl)butanamide
  参考文献：
  名称：

  InX3-catalyzed haloamidation of vinyl arenes: a facile synthesis of α-bromo- and α-fluoroamides

  摘要：

  A variety of alkenes are converted into the corresponding alpha-fluoroamides in high yields by selectfluor (TM) in the presence of 10 mol % of InF3 in nitrile solution. alpha-Bromoamides are obtained with NBS in the presence of 10 mol % InBr3 under similar conditions. The use of Lewis acid in haloamidation significantly improved the yields and reaction rates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.12.090

文献信息

• InX3-catalyzed haloamidation of vinyl arenes: a facile synthesis of α-bromo- and α-fluoroamides
  作者：J.S. Yadav、B.V. Subba Reddy、D. Narasimha Chary、D. Chandrakanth

  DOI：10.1016/j.tetlet.2008.12.090

  日期：2009.3

  A variety of alkenes are converted into the corresponding alpha-fluoroamides in high yields by selectfluor (TM) in the presence of 10 mol % of InF3 in nitrile solution. alpha-Bromoamides are obtained with NBS in the presence of 10 mol % InBr3 under similar conditions. The use of Lewis acid in haloamidation significantly improved the yields and reaction rates. (C) 2009 Elsevier Ltd. All rights reserved.