N,N,N',N'-tetraethylfumaramide | 37511-04-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N,N',N'-tetraethylfumaramide
• 英文别名: N,N,N',N'-tetraethyl fumaramide；(E)-N,N,N',N'-tetraethylbut-2-enediamide
• CAS: 37511-04-9
• 化学式: C₁₂H₂₂N₂O₂
• 分子量: 226.319
• InChiKey: OLWOGCIWEBYFKD-MDZDMXLPSA-N

物化性质

• 沸点：
  170 °C(Press: 0.08 Torr)
• 密度：
  0.988±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-tetraethylfumaramide 在 氧气 、 臭氧 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 生成 Glyoxylsaeure-diethylamid
  参考文献：
  名称：

  Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction

  摘要：

  A one-pot, three-component process is described which involves both organo- and enzyme-catalysed carbon-carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilution with additional aqueous buffer, and addition of pyruvate and an aldolase enzyme variant, a second aldol reaction occurs to yield a final product. Crucially, it was possible to develop a reaction in which both the organo- and enzyme-catalysed reactions could be performed in the same aqueous buffer system. The reaction described is the first example of a one-pot, three-component reaction in which the two carbon-carbon bond-forming processes are catalysed using the combination of an organocatalyst and an enzyme. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.02.010
• 作为产物：
  描述：

  反丁烯二酰氯 、 二乙胺 在 乙醚 作用下， 生成 N,N,N',N'-tetraethylfumaramide
  参考文献：
  名称：

  Prevalence and etiology of vertigo in adult rural population

  摘要：

  A survey on 10.000 adults between the age of 20 and 79 years out of a total population of 66.186 persons in rural settlements under the inrisduction of Union Territory of Chandigarh between June 1993 to June 1995 was conducted to find out the prevalence and various causes of vertigo. In general community, in rural population, we found that more people suffer from non-otologic vertigo rather than otologic vertigo. We found overall prevalence of vertigo in rural adult community to be 0.71%. Vertigo secondary to cardiovascular disease was most common and prevalent in 0.32% of population. Neurologic disease accounted for vertigo in 0.14%, metabolic disease in 0.09% and otologic disease 0.08%. Miscellaneous disorders were present in remaining 0.08% of population studied. To the best of our knowledge this study represents the first population based survey of prevalence of various causes of vertigo in general community in adult rural population.

  DOI：

  10.1007/bf02910976

文献信息

• Diruthenium(I,I) Catalysts for the Formation of β- and γ-Lactamsvia Carbenoid CH Insertion of α-Diazoacetamides
  作者：Markus Grohmann、Stefan Buck、Lutz Schäffler、Gerhard Maas

  DOI：10.1002/adsc.200606108

  日期：2006.10

  Intramolecular carbenoid CH insertion of five α-diazoacetamides [N2CHCONR2, NR2=NEt2 (3a), NBu2 (3b), N(i-Pr)2 (3c), N(CH2Ph)2 (3d), N(i-Pr)(CH2Ph) (3e)], was investigated using as catalysts dinuclear Ru(I,I) complexes of the type [Ru2(μ-L1)2(CO)4L22], where L1 is a bidentate bridging acetate, calix[4]arenedicarboxylate, saccharinate, pyridin-2-olate, or triazenide ligand, as well as [RuCl2(p-cymene)]2

  五个α-重氮乙酰胺[N 2 CHCONR 2，NR 2 = NEt 2（3a），NBu 2（3b），N（i- Pr）2（3c），N（CH 2 Ph）2（3d），N（异PR）（CH 2 PH）（3E）]，使用研究作为催化剂的双核钌（I，I）所述类型的复合物的[Ru 2（μ-L 1）2（CO）4大号2 2 ]，其中L 1是桥接乙酸盐，杯[4]芳烯二羧酸盐，糖精，吡啶-2-油酸酯或三氮烯配体以及[RuCl 2（p- cymene）] 2的双齿。发现Ru（I，I）配合物是类胡萝卜素环化反应的合适催化剂，除了3a的情况。使用重氮酰胺3b–e，[Ru 2（μ-囊）2（CO）5 ] 2（sa c =糖精）和[Ru 2（μ-6-氯吡啶-2-醇酸酯）2（CH 3 CN）2（ CO）4 ]与Rh 2（OAc）4一样有效在相同条件下，尽管观察到环化的区域选择性和化学选择性有些差异。类胡萝卜素环化反应从重氮酰胺3
• Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes
  作者：Mingyang Fu、Long Chen、Yongpeng Jiang、Zhong-Xing Jiang、Zhigang Yang

  DOI：10.1021/acs.orglett.5b03080

  日期：2016.2.5

  A highly practical copper-catalyzed intermolecular halotrifluoromethylation of alkenes has been developed under mild reaction conditions. A variety of Cl/Br-containing trifluoromethyl derivatives were directly synthesized from a wide range of alkenes, including electron-deficient and unactivated alkenes.

  在温和的反应条件下，已开发出高度实用的铜催化的烯烃分子间卤代三氟甲基化反应。从多种烯烃（包括缺电子和未活化的烯烃）直接合成了多种含Cl / Br的三氟甲基衍生物。
• Thermally and Photochemically Induced Dethreading of Fumaramide-Based Kinetically Stable Pseudo[2]rotaxanes
  作者：Alberto Martinez-Cuezva、Fatima Morales、Grace R. Marley、Adrian Lopez-Lopez、Juan Carlos Martinez-Costa、Delia Bautista、Mateo Alajarin、Jose Berna

  DOI：10.1002/ejoc.201900073

  日期：2019.6.10

  The thermal‐ and light‐driven dethreading processes of kinetically stable pseudo[2]rotaxanes bearing tetrasubstituted‐fumaramides as threads are described. The influence of the stopper size, the flexibility of the thread and macrocycle and the strength of the intercomponent interactions on the disconnection rate have been thoroughly studied.

  描述了以四取代富马酰胺为线的动力学稳定的假[2]轮烷的热和光驱动脱线过程。彻底研究了塞子尺寸，螺纹和大环的柔韧性以及组分间相互作用的强度对断开速率的影响。
• Laminated multilayer structure
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0016617A1

  公开（公告）日：1980-10-01

  The multilayer structure is composed of a grafted high-density polyethylene resin layer directly attached to a resin layer of polyamide resin, polyester resin or a saponified copolymer of ethylene and vinyl acetate, or to a metal layer. In such structures it has been difficult to provide adequate bond strength between the iayers, and delamination has previously tended to occur under severe operating conditions. The grafted high-density polyethylene resin layer composed of (a) 97 to 50 parts by weight of a high-density polyethylene resin having a density of 0.945 to 0.970 g/cm3 and being grafted with an aliphatic dicarboxylic acid or functional derivative thereof, with or without a high-density polyethylene resin having a density of 0.945 to 0.970 g/cm3, (b) 3 to 50 parts by weight of an ethylene/4-methyl-1-pentene copolymer having an ethylene content of 93 to 99.5 moie% and a melt index at 190°C of 0.1 to 10 g/10 min., and (c) 0 to 20 parts by weight of a rubbery synthetic polymer or copolymer, the parts by weight of (a), (b) and (c) being per 100 parts by weight of resins (a) and (b) combined. The structures of the invention find use as, for example, packaging materials and building panels.

  多层结构由接枝高密度聚乙烯树脂层直接连接到聚酰胺树脂、聚酯树脂或乙烯和醋酸乙烯的皂化共聚物树脂层或金属层组成。在这种结构中，很难在树脂层之间提供足够的粘接强度，而且以前在恶劣的工作条件下往往会出现分层现象。由以下材料组成的接枝高密度聚乙烯树脂层 (a) 97 至 50 份（按重量计）密度为 0.945 至 0.970 克/立方厘米的高密度聚乙烯 树脂，并与脂肪族二羧酸或其官能衍生物接枝，以及或不接枝密度为 0.945 至 0.970 克/立方厘米的高密度聚乙烯树脂、 (b) 3 至 50 重量份的乙烯/4-甲基-1-戊烯共聚物，其乙烯含量为 93 至 99.5%，190°C 时的熔融指数为 0.1 至 10 克/10 分钟，和 (c) 0 至 20 重量份的橡胶合成聚合物或共聚物，(a)、(b)和(c)的重量份数为每 100 重量份树脂(a)和(b)的总和。 本发明的结构可用作包装材料和建筑板材等。
• Process for preparing a polyphenylene sulfide resin composition
  申请人：Tosoh Corporation

  公开号：EP0499468A2

  公开（公告）日：1992-08-19

  A polyphenylene sulfide resin composition improved in the impact strength, toughness, high temperature resistance and solvent resistance properties is disclosed. The composition comprises (A) 60 - 99.5% by weight of a thermally cured polyphenylene sulfide material having a melt viscosity of 500 - 30,000 poises and which has been derived, by thermally curing, from a polyphenylene sulfide having a melt viscosity of 400 poises of higher and containing 0.05 - 5 mol% of amino groups on the basis of the phenylene sulfide repeating units, and (B) 40 - 0.5% by weight of a modified polyethylene material comprising at least one polyethylene onto which at least one unsaturated carboxylic acid and/or derivative thereof is graft-copolymerized in a proportion of 0.1 - 10% by weight of the total weight of said modified polyethylene material.

  本发明公开了一种聚苯硫醚树脂组合物，该组合物在抗冲击强度、韧性、耐高温性和耐溶剂性方面都有所改进。该组合物包括 (A) 60 - 99.5% （按重量计）的热固化聚苯硫醚材料，其熔体粘度为 500 - 30,000 波，通过热固化从熔体粘度高于 400 波的聚苯硫醚中提取，并含有 0.05 - 5 摩尔%的氨基（以亚苯基硫醚重复单元为基础），以及 (B) 40 - 0.5%（按重量计）的改性聚乙烯材料，该材料包含至少一种聚乙烯，在该聚乙烯上至少有一种不饱和羧酸和/或其衍生物被接枝共聚，其比例为所述改性聚乙烯材料总重量的 0.1 - 10%（按重量计）。