N-α-methoxy-ethyl propionamide | 55525-53-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-α-methoxy-ethyl propionamide
• 英文别名: N-(alpha-methoxyethyl)-propionic acid amide；N-(1-methoxyethyl)propanamide
• CAS: 55525-53-6
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: WZVAZXMGZSIPKN-UHFFFAOYSA-N

物化性质

• 沸点：
  238.1±23.0 °C(Predicted)
• 密度：
  0.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-α-methoxy-ethyl propionamide 生成 N-vinylpropionamide
  参考文献：
  名称：

  STACKMAN, R. W.;SUMMERVILLE, R. H.;SUMMERVILLE, J. E. ,, JR.

  摘要：

  DOI：
• 作为产物：
  描述：

  丙酰胺 以75%的产率得到N-α-methoxy-ethyl propionamide
  参考文献：
  名称：

  Production of N-vinyl carboxylic acid amides

  摘要：

  该发明涉及从二甲基缩醛和羧酸酰胺（如乙酰胺）制备N-α-烷氧乙基羧酸酰胺，以及制备次级N-乙烯基羧酸酰胺（如N-乙烯基乙酰胺）的方法。二甲基缩醛和羧酸酰胺的反应涉及一个平衡不均反应，其中过量的二甲基缩醛以足够的量使用，例如，摩尔比为2:1至60:1，以将平衡推向所需的N-α-烷氧乙基羧酸酰胺中间体产物。平衡在约0.1至150小时内达到，在温度约0摄氏度至100摄氏度。根据已知的热解反应，将中间体N-α-烷氧乙基羧酸酰胺进行热解，以获得相应的N-乙烯基乙酰胺。

  公开号：

  US04554377A1

文献信息

• XtalFluor-E® mediated proto-functionalization of <i>N</i>-vinyl amides: access to <i>N</i>-acetyl <i>N</i>,<i>O</i>-acetals
  作者：Y. Yi、H. Gholami、M. G. Morrow、B. Borhan

  DOI：10.1039/c7ob02283b

  日期：——

  few years. Here we report its use with protic nucleophiles in a catalytic manner for the in situ generation of protons that lead to the proteo functionalization of activated olefins. Utilizing the latter protocol, proteo etherification of enamides gives rise to N,O-acetals in nearly quantitative yields.

  在过去的几年中，XtalFluor-E®已广泛用于各种反应中。在这里，我们报告其与质子亲核体以催化方式用于质子的原位生成，从而导致活化烯烃的蛋白官能化。利用后一种方案，酰胺的蛋白醚化以几乎定量的产率产生N，O-乙缩醛。
• COMPOSITION FOR PRODUCING N-VINYL CARBOXYLIC ACID AMIDE
  申请人：SHOWA DENKO K.K.

  公开号：US20220112155A1

  公开（公告）日：2022-04-14

  The present invention relates to a composition for producing an N-vinylcarboxylic acid amide, the composition including (A) an N-(1-alkoxyethyl)carboxylic acid amide and (B) a carboxylic acid amide other than the N-(1-alkoxyethyl)carboxylic acid amide and the N-vinylcarboxylic acid amide, and satisfying the following conditions (1) to (4): (1) the composition has a melting point of 0 to 30° C.; (2) a water content is 0 to 1.00% by mass in a total amount of the composition; (3) a content ratio of the component (A) to the component (B) is 4.0 to 20.0 in terms of a molar ratio; and (4) a 5% by mass aqueous solution of the composition has a pH of 4.0 to 8.0. The present invention also relates to a method for producing an N-vinylcarboxylic acid amide, the method including thermally decomposing or catalytically decomposing the composition for producing an N-vinylcarboxylic acid amide.

  本发明涉及一种用于生产N-乙烯基羧酸酰胺的组合物，该组合物包括（A）N-(1-烷氧基乙基)羧酸酰胺和（B）除N-(1-烷氧基乙基)羧酸酰胺和N-乙烯基羧酸酰胺以外的羧酸酰胺，并满足以下条件（1）至（4）：（1）组合物的熔点为0至30℃；（2）组合物总量中的水含量为0至1.00%质量分数；（3）组分（A）与组分（B）的含量比为摩尔比4.0至20.0；（4）组合物的5%质量分数水溶液的pH值为4.0至8.0。本发明还涉及一种生产N-乙烯基羧酸酰胺的方法，该方法包括热分解或催化分解上述用于生产N-乙烯基羧酸酰胺的组合物。
• METHOD OF PRODUCING N-VINYLCARBOXYLIC ACID AMIDE
  申请人：SHOWA DENKO K.K.

  公开号：US20210214302A1

  公开（公告）日：2021-07-15

  A method for producing an N-vinylcarboxylic acid amide is provided, the method focusing on unsaturated aldehydes that are contained as impurities generated during a reaction. The method for producing an N-vinylcarboxylic acid amide includes a step for controlling the contained amount of unsaturated aldehydes in the N-vinylcarboxylic acid amide to be not more than 20 mass ppm.

  提供了一种生产N-乙烯基羧酸酰胺的方法，该方法侧重于在反应过程中生成的不饱和醛作为杂质。生产N-乙烯基羧酸酰胺的方法包括一步，控制N-乙烯基羧酸酰胺中含有的不饱和醛的含量不超过20质量ppm。
• Process for preparing N-(.alpha.-alkoxyethyl)-carboxylic acid amides
  申请人：Hoechst Aktiengesellschaft

  公开号：US04036712A1

  公开（公告）日：1977-07-19

  N-.alpha.-alkoxyethyl carboxylic compounds of the formula ##STR1## wherein R.sup.5 means hydrogen, an alkyl group having from 1 to 6 carbon atoms or an aryl group having from 6 to 10 carbon atoms, especially hydrogen or a methyl group, and Wherein R.sup.6 means an alkyl group having from 1 to 6 carbon atoms, especially a methyl group, Are prepared by electrolysis of secondary N-ethylcarboxylic acid amides of the formula ##STR2## with alcohols of the formula R.sup.6 OH, R.sup.5 and R.sup.6 having the aforesaid meaning, while employing tetraalkyl ammonium tetrafluoroborates, tetraalkyl ammonium hexafluorophosphates as well as alkali-tetrafluoroborates as conducting salts and a current quantity of at least 2.5 Faraday/mole of N-ethylcarboxylic acid amide. The N-.alpha.-alkylethyl compounds are valuable intermediate products for the preparation of N-vinyl carboxylic acid amides which may then be converted to water-soluble polymers having multiple properties for technical application.

  该文献描述了一种制备N-.alpha.-烷氧基乙基羧酸化合物的方法，该化合物的化学式为##STR1##其中R.sup.5表示氢，具有1至6个碳原子的烷基或具有6至10个碳原子的芳基，特别是氢或甲基基团，R.sup.6表示具有1至6个碳原子的烷基，特别是甲基基团。该方法通过使用四烷基铵四氟硼酸盐，四烷基铵六氟磷酸盐以及碱性四氟硼酸盐作为导电盐，并且至少使用2.5法拉/摩尔的N-乙基羧酸酰胺电荷量，将化合物##STR2##与具有上述含义的醇R.sup.6 OH进行电解反应。该N-.alpha.-烷基乙基化合物是制备N-乙烯基羧酸酰胺的有价值的中间产物，然后可以将其转化为具有多种技术应用性能的水溶性聚合物。
• Process producing n-(1-alkoxyethyl)carboxylic amides
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP0799820A1

  公开（公告）日：1997-10-08

  A process for producing N-(1-alkoxyethyl)carboxylic amides by reacting alcohols of 1-5 carbon atoms with N-vinylcarboxylic amides in the presence of an acidic catalyst, or by utilizing unreacted starting material, unreacted intermediate or unrecovered product for synthesis of N-(1-alkoxyethyl)carboxylic amides. A process for producing N-(1-alkoxyethyl)carboxylic amides by adding a water-soluble strong acid during reaction between a carboxylic amide and a starting material containing acetaldehyde and alcohol and/or a starting material containing an acetal, in an amount of 2 x 10-3 to 3 x 10-1 equivalents to 1 mole of the carboxylic amide in the starting material, and using a strongly acidic ion-exchange resin as the catalyst.

  一种在酸性催化剂存在下通过 1-5 个碳原子的醇与 N-乙烯基羧酸酰胺反应生产 N-(1-烷氧基乙基)羧酸酰胺的工艺，或利用未反应的起始原料、未反应的中间产物或未还原产物合成 N-(1-烷氧基乙基)羧酸酰胺的工艺。一种生产 N-(1-烷氧基乙基)羧酸酰胺的工艺，在羧酸酰胺与含有乙醛和醇的起始原料和/或含有缩醛的起始原料反应过程中加入水溶性强酸，加入量为起始原料中 1 摩尔羧酸酰胺的 2 x 10-3 至 3 x 10-1 等量，并使用强酸性离子交换树脂作为催化剂。