N-Benzotriazol-1-ylmethyl-propionamide | 164299-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: N-Benzotriazol-1-ylmethyl-propionamide
• 英文别名: N-(benzotriazol-1-ylmethyl)propanamide
• CAS: 164299-68-7
• 化学式: C₁₀H₁₂N₄O
• 分子量: 204.231
• InChiKey: UBUNOJSHGONUTB-UHFFFAOYSA-N

物化性质

• 沸点：
  465.3±28.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  异丙醇 、 N-Benzotriazol-1-ylmethyl-propionamide 在 sodium 作用下， 以94%的产率得到N-Isopropoxymethyl-propionamide
  参考文献：
  名称：

  Generalization of the Benzotriazole-Mediated Introduction of N-Substituents into Amides

  摘要：

  N-(Benzotriazol-1-ylmethyl) amides 2, easily available by condensation of BtCH(2)OH with amides, are used for the preparation of a variety of N-substituted amides such as the homoallyl, 1,3-butadienyl, and 2,2-diphenylcyclopropyl derivatives by displacement of the benzotriazole group under different conditions.

  DOI：

  10.1021/jo00118a015
• 作为产物：
  描述：

  1H-苯并三唑-1-甲醇 、 丙酰胺 在 溶剂黄146 作用下， 反应 6.0h， 以63%的产率得到N-Benzotriazol-1-ylmethyl-propionamide
  参考文献：
  名称：

  Generalization of the Benzotriazole-Mediated Introduction of N-Substituents into Amides

  摘要：

  N-(Benzotriazol-1-ylmethyl) amides 2, easily available by condensation of BtCH(2)OH with amides, are used for the preparation of a variety of N-substituted amides such as the homoallyl, 1,3-butadienyl, and 2,2-diphenylcyclopropyl derivatives by displacement of the benzotriazole group under different conditions.

  DOI：

  10.1021/jo00118a015

文献信息

• Generalization of the Benzotriazole-Mediated Introduction of N-Substituents into Amides
  作者：Alan R. Katritzky、Alexey V. Ignatchenko、Hengyuan Lang

  DOI：10.1021/jo00118a015

  日期：1995.6

  N-(Benzotriazol-1-ylmethyl) amides 2, easily available by condensation of BtCH(2)OH with amides, are used for the preparation of a variety of N-substituted amides such as the homoallyl, 1,3-butadienyl, and 2,2-diphenylcyclopropyl derivatives by displacement of the benzotriazole group under different conditions.