2-(4,5-二氨基-3-甲基吡唑-1-基)乙醇 | 132026-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(4,5-二氨基-3-甲基吡唑-1-基)乙醇
• 英文名称: 4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole
• 英文别名: 4,5-diamino-1-(2-hydroxyethyl)-3-methyl-1H-pyrazole；1-(2-hydroxyethyl)-3-methyl-4,5-diaminopyrazole；4,5-Diamino-1-(2-hydroxyethyl)-3-methylpyrazole；4,5-diamino-1-(hydroxyethyl)-3methylpyrazole；4,5-diamino-1-(β-hydroxyethyl)-3-methyl pyrazole；4,5-diamino-1(β-hydroxyethyl)-3-methylpyrazole；4,5-Diamino-3-methyl-1H-pyrazole-1-ethanol；2-(4,5-diamino-3-methylpyrazol-1-yl)ethanol
• CAS: 132026-22-3
• 化学式: C₆H₁₂N₄O
• 分子量: 156.187
• InChiKey: QBOQGVXXIUOJRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  90.1
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4,5-二氨基-3-甲基吡唑-1-基)乙醇 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 生成 4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole dihydrochloride
  参考文献：
  名称：

  Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation

  摘要：

  该发明涉及一种用于氧化染色角蛋白纤维的新型组合物，包括至少一种特定的二氨基吡唑衍生物，以及使用该组合物的染色过程，新型二氨基吡唑衍生物和其制备过程。

  公开号：

  US06338741B1
• 作为产物：
  描述：

  5-amino-1-(β-hydroxyethyl)-3-methyl-4-nitrosopyrazole 在 钯 Arbocel 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 2.0h， 以yielding the title compound as a foam (800 mg, 97%)的产率得到2-(4,5-二氨基-3-甲基吡唑-1-基)乙醇
  参考文献：
  名称：

  Diazepine antiallergy agents

  摘要：

  式(I)、(II)或(III)的血小板活化因子拮抗剂：##STR1## 其中，A是可选取代的苯、吡啶、萘、喹啉、噻吩、苯并噻吩、吡唑或异噻唑；X是O、S或NH；Y是1,4-苯撑基或公式##STR2##的基团；R.sup.1是H或可选取代的C.sub.1-C.sub.4烷基；R.sup.2和R.sup.3是H或C.sub.1-C.sub.4烷基；B是可选的含氮5-或6-元环，Het是可选取代的含氮5-元杂环或吡啶环，该环可选择与苯或含氮杂环环融合。

  公开号：

  US05008263A1

文献信息

• [EN] DYE COMPOSITION COMPRISING A CATIONIC O-ALKYL-SUBSTITUTED META-PHENYLENEDIAMINE DERIVATIVE<br/>[FR] COMPOSITION DE TEINTURE COMPRENANT UN DÉRIVÉ DE MÉTA-PHÉNYLÈNEDIAMINE CATIONIQUE À SUBSTITUTION ALKYLE O
  申请人：OREAL

  公开号：WO2014026952A1

  公开（公告）日：2014-02-20

  The invention relates to a meta-phenylenediamine compound of formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: R represents a hydrogen or halogen atom; a C1-C4 alkyl radical; a carboxyl radical or a (C1-C4) alkoxycarbonyl radical, R1 represents a linear C1-C10 alkyl radical substituted with a cationic radical, said alkyl radical being optionally interrupted with one or more oxygen atoms and/or with one or more NR6 groups, said cationic radical being optionally substituted with one or more radicals chosen from C1-C4 alkoxy or C1-C4 (hydroxy )alkyl; R6 represents a hydrogen atom or a linear or branched C1-C4 alkyl radical; An- represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.

  该发明涉及以下式（I）的一个甲苯二胺类化合物，以及其与酸的加合盐和溶剂化合物：其中：R代表氢或卤素原子；一个C1-C4烷基基团；一个羧基或（C1-C4）烷氧羰基基团，R1代表一个线性的C1-C10烷基基团，该基团被一个阳离子基团取代，所述烷基基团可以选择性地被一个或多个氧原子和/或一个或多个NR6基团中断，所述阳离子基团可以选择性地被一个或多个从C1-C4烷氧基或C1-C4（羟基）烷基中选择的基团取代；R6代表氢原子或线性或支链的C1-C4烷基基团；An-代表一个有机或无机且在化妆品中可接受的阴离子或阴离子混合物。
• Novel double para-phenylenediamines joined by a linker arm substituted with at least one group chosen from hydroxyl, alkoxy, and/or amino groups and method of dyeing keratinous fibers
  申请人：Sabelle Stéphane

  公开号：US20070011827A1

  公开（公告）日：2007-01-18

  Disclosed herein is a novel family of double para-phenylenediamines joined by a linker arm comprising at least one substituent chosen from hydroxyl, alkoxy, and/or amino substituents. Also disclosed herein is a dyeing composition comprising, in a medium suitable for dyeing, at least one para-phenylenediamine joined by a linker arm comprising at least one substituent chosen from hydroxyl, alkoxy, and/or amino substituents. Further disclosed herein is a method for dyeing keratin fibers comprising applying such a dyeing composition to the keratin fibers. A multi-compartment kit comprising at least one dyeing composition of the present disclosure and at least one oxidizing composition is also disclosed herein.

  本文揭示了一类新型的双对苯二胺家族，其由至少选择自羟基、烷氧基和/或氨基取代基的连接臂连接在一起。本文还揭示了一种染料组合物，其中在适合染色的介质中，至少有一种通过连接臂连接的对苯二胺，其连接臂包含至少选择自羟基、烷氧基和/或氨基取代基。此外，本文还揭示了一种染色角蛋白纤维的方法，包括将这种染料组合物应用于角蛋白纤维。本文还揭示了一种多室套装，其中至少包括本公告中的染料组合物和至少一种氧化剂组合物。
• Diazepine antiallergy agents
  申请人：Pfizer Inc.

  公开号：US05008263A1

  公开（公告）日：1991-04-16

  Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole, X is O, S or NH Y is 1,4 phenylene or a group of formula ##STR2## R.sup.1 is H or optionally substituted C.sub.1 -C.sub.4 alkyl, R.sup.2 and R.sup.3 are H or C.sub.1 -C.sub.4 alkyl, B is an optionally fused 5- or 6-membered ring containing nitrogen atoms, Het is an optionally substituted 5-membered heterocyclic ring containing nitrogen or a pyridine ring, the ring optionally being fused to benzene or nitrogen-containing heterocyclic ring.

  公式（I）、（II）或（III）的血小板活化因子拮抗剂：##STR1##其中A是可选择取代的苯、吡啶、萘、喹啉、噻吩、苯并噻吩、吡唑或异噻唑，X是O、S或NH，Y是1,4-苯撑基或公式##STR2##的基团，R.sup.1是H或可选择取代的C.sub.1-C.sub.4烷基，R.sup.2和R.sup.3是H或C.sub.1-C.sub.4烷基，B是可选择融合的含氮的5-或6-成员环，Het是可选择取代的含氮的5-成员杂环环或吡啶环，该环可选择与苯或含氮的杂环环融合。
• N-alkylpolyhydroxylated secondary para-phenylenediamines, dye compositions comprising them, processes, and uses thereof
  申请人：Sabelle Stephane

  公开号：US20060026777A1

  公开（公告）日：2006-02-09

  The present disclosure relates to novel N-alkylpolyhydroxylated secondary para-phenylenediamines, to processes for preparing them, to compositions for dyeing keratin fibers, for example keratin fibers such as the hair, comprising, in a medium that is suitable for dyeing, at least one such secondary para-phenylenediamine. The present disclosure also relates to processes for dyeing keratin fibers with the compositions according to the present disclosure, and to dyeing kits containing such compositions.

  本发明涉及新型N-烷基多羟基化二级对苯二胺，涉及制备它们的方法，涉及用于染色的角蛋白纤维，例如头发的组合物，其包含在适合染色的介质中，至少一种此类二级对苯二胺。本发明还涉及使用根据本发明的组合物对角蛋白纤维进行染色的方法，以及包含此类组合物的染色套装。
• 3-deoxyglucosone and skin
  申请人：——

  公开号：US20030219440A1

  公开（公告）日：2003-11-27

  The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

  该发明涉及一种从皮肤中去除3-去氧葡萄糖酮和其他α-二酮糖的方法。该发明还涉及抑制皮肤中3-去氧葡萄糖酮和其他α-二酮糖的产生和功能的方法。该发明还涉及治疗与皮肤相关的3-去氧葡萄糖酮和其他α-二酮糖相关疾病和障碍的方法。