(Z)-5-(4-(benzyloxy)benzylidene)-2-(4-chlorophenyl)-5H-thiazol-4-one | 1380593-22-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-5-(4-(benzyloxy)benzylidene)-2-(4-chlorophenyl)-5H-thiazol-4-one
• 英文别名: (5Z)-2-(4-chlorophenyl)-5-[(4-phenylmethoxyphenyl)methylidene]-1,3-thiazol-4-one
• CAS: 1380593-22-5
• 化学式: C₂₃H₁₆ClNO₂S
• 分子量: 405.905
• InChiKey: YUCHTRMJODWAEZ-STZFKDTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对氯苯甲腈 、 4-苄氧基苯甲醛 、 巯基乙酸 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以38%的产率得到(Z)-5-(4-(benzyloxy)benzylidene)-2-(4-chlorophenyl)-5H-thiazol-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors

  摘要：

  A class of 5-lipoxygenase (5-LO) inhibitors characterized by a central 5-benzylidene-2-phenyl-thiazolinone scaffold was synthesized as a new series of molecular modifications and extensions of a previously reported series. Compounds were tested in a cell-based and a cell-free assay and furthermore evaluated for their influence on cell viability. The presented substituted thiazolinone scaffold turned out to be essential for both the 5-LO inhibitory activity and the non-cytotoxic profile. With (Z)-5-(4-methoxybenzylidene)-2-(naphthalen-2-yl)-5H-thiazol-4-one (2k, ST1237), a potent, direct, non-cytotoxic 5-LO inhibitor with IC50 of 0.08 mu M and 0.12 mu M (cell-free assay and intact cells), we present a promising lead optimization and development for further investigations as novel anti-inflammatory drug. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.04.003