2-(4-三氟甲氧基苯基)-1H-咪唑 | 885271-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(4-三氟甲氧基苯基)-1H-咪唑
• 英文名称: 2-(4-(trifluoromethoxy)phenyl)-1H-imidazole
• 英文别名: 2-[4-(trifluoromethoxy)phenyl]-1H-imidazole
• CAS: 885271-86-3
• 化学式: C₁₀H₇F₃N₂O
• 分子量: 228.174
• InChiKey: CQPVUIDPCVCNCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE<br/>[FR] PTÉRIDINONES EN TANT QU'INHIBITEURS DE POLO-LIKE KINASE
  申请人：ELAN PHARM INC

  公开号：WO2011079114A1

  公开（公告）日：2011-06-30

  The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

  本发明提供了具有如下结构式(I)的化合物或其盐或溶剂化物，其中环A、X、R1、R2、R3、R4、R5和R6的定义如本文所述。本发明还提供了包括本发明化合物的药物组合物以及制造和使用本发明化合物和组合物的方法，例如，在治疗和预防各种疾病，如帕金森病。
• Novel imidazole derivatives
  申请人：Aebi Johannes

  公开号：US20090012063A1

  公开（公告）日：2009-01-08

  The invention is concerned with novel imidazole derivatives of formula (I), wherein m, E, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

  这项发明涉及公式（I）的新型咪唑衍生物， 其中 m，E，R1，R2，R3，R4，R5，R6和R7如描述和索赔中所定义，并且其生理上可接受的盐。这些化合物是CCR-2受体、CCR-5受体和/或CCR-3受体的拮抗剂，可用作药物。
• [EN] 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS<br/>[FR] COMPOSES 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE POUR LE TRAITEMENT DE LA TUBERCULOSE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005042542A1

  公开（公告）日：2005-05-12

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.

  本发明提供了一种由以下一般式表示的2,3-二氢-6-硝基咪唑[2,1-b]噁唑化合物：(1)在上述式(1)中，R1代表氢原子或C1-C6烷基，n代表0至6的整数，R1和-(CH2)nR2可以与下面的式(30)一起形成一个螺环，与相邻的碳原子一起（在下面的式中，RRR代表可能在哌啶环上具有取代基的哌啶基），(30)和R2代表苯并噻唑氧基、喹啉氧基、吡啶氧基或类似物。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型耐酸细菌具有出色的杀菌作用。
• INHIBITORS OF POLO-LIKE KINASE
  申请人：Galemmo Robert A.

  公开号：US20110207716A1

  公开（公告）日：2011-08-25

  The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E 1 , E 2 , R 1 , R 2 , R 3 and R 4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

  本发明提供了具有以下结构的化合物（I）的盐或溶剂，其中环A、E1、E2、R1、R2、R3和R4在此定义。本发明还提供了包括本发明化合物的制药组合物以及使用本发明化合物和组合物的方法，例如在治疗和预防各种疾病，如帕金森病方面的应用。
• Inhibitors of Polo-Like Kinase
  申请人：Galemmo, JR. Robert A.

  公开号：US20120115848A1

  公开（公告）日：2012-05-10

  The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, U 1 , U 2 , U 3 , R 2 , R 3 and R 4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

  本发明提供具有以下结构的化合物（I）或其盐或溶剂化物，其中环A、U1、U2、U3、R2、R3和R4如本文所定义。该发明还提供包括该发明化合物的制药组合物以及制备和使用该发明化合物和组合物的方法，例如用于治疗和预防各种疾病，如帕金森病。