1-butoxy-2-isobutoxybenzene | 1396943-09-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-butoxy-2-isobutoxybenzene
• 英文别名: 1-Butoxy-2-(2-methylpropoxy)benzene
• CAS: 1396943-09-1
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.327
• InChiKey: TWFBKONSIQLWJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-butoxy-2-isobutoxybenzene 在 sodium tetrahydroborate 、 硫酸 、 palladium 10% on activated carbon 、 硝酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Tuning the mesomorphic properties of liquid-crystalline dibenzotetraaza[14]annulenes — discotic nematic phases of tetraalkoxy-substituted derivatives

  摘要：

  A homologous series of five tetrasubstituted dibenzotetraaza[14]annulene-based discotic mesogens was prepared and studied using polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). A nematic phase was identified for the product bearing two peripheral isobutoxy and two dode-cyloxy substituents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.053
• 作为产物：
  描述：

  邻苯二酚 在 4-甲基苯磺酸吡啶 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 1-butoxy-2-isobutoxybenzene
  参考文献：
  名称：

  Tuning the mesomorphic properties of liquid-crystalline dibenzotetraaza[14]annulenes — discotic nematic phases of tetraalkoxy-substituted derivatives

  摘要：

  A homologous series of five tetrasubstituted dibenzotetraaza[14]annulene-based discotic mesogens was prepared and studied using polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). A nematic phase was identified for the product bearing two peripheral isobutoxy and two dode-cyloxy substituents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.053

文献信息

• [EN] ISOCHROMENONES USEFUL IN THE TREATMENT OF INFLAMMATION<br/>[FR] ISOCHROMÉNONES UTILISABLES DANS LE TRAITEMENT DE L'INFLAMMATION
  申请人：BIOLIPOX AB

  公开号：WO2010076564A2

  公开（公告）日：2010-07-08

  This invention is directed to compounds of formula (I): wherein R1, R2, R3, Rx, Ry, m and n have meanings given in the description, or pharmaceutically acceptable salts, solvates or prodrugs thereof, which are useful as PDE4, PDE7 or PDE4 and PDE7 inhibitors, and therefore useful e.g. in the treatment and/or prevention of diseases and conditions associated with inflammation.
• Tuning the mesomorphic properties of liquid-crystalline dibenzotetraaza[14]annulenes — discotic nematic phases of tetraalkoxy-substituted derivatives
  作者：Jarosław Grolik、Łukasz Dudek、Julita Eilmes

  DOI：10.1016/j.tetlet.2012.07.053

  日期：2012.9

  A homologous series of five tetrasubstituted dibenzotetraaza[14]annulene-based discotic mesogens was prepared and studied using polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). A nematic phase was identified for the product bearing two peripheral isobutoxy and two dode-cyloxy substituents. (C) 2012 Elsevier Ltd. All rights reserved.