N-(3-(4-chlorophenyl)propyl)-4-methylaniline | 1500603-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-(4-chlorophenyl)propyl)-4-methylaniline
• 英文别名: N-[3-(4-chlorophenyl)propyl]-4-methylaniline
• CAS: 1500603-32-6
• 化学式: C₁₆H₁₈ClN
• 分子量: 259.779
• InChiKey: KOXOJEOEOWXCEK-UHFFFAOYSA-N

物化性质

• 沸点：
  401.8±33.0 °C(predicted)
• 密度：
  1.125±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-氯苯乙烯 、 4-硝基甲苯 在 丙醇 、 一氧化碳 、 氢气 、 十六烷基三甲基溴化铵 作用下， 以 水 为溶剂， 以82%的产率得到N-(2-(4-chlorophenyl)propyl)-4-methylaniline
  参考文献：
  名称：

  Regioselective Hydroaminomethylation of Vinylarenes by a Sol–Gel Immobilized Rhodium Catalyst

  摘要：

  In the course of our studies toward the development of new heterogeneous conditions for better controlling regioselectivity in organic reactions, we investigated the application of sol-gel immobilized organometallic catalyst for regioselective hydroaminomethylation of vinylarenes with aniline or nitroarene derivatives in an aqueous microemulsion. By immobilization of 6 mol % [Rh(cod)Cl]2 within a hydrophobic silica sol-gel matrix we were able to perform efficient hydroaminomethylation under mild conditions and isolate 2-arylpropylamines with high regioselectivity. The regioselectivity of the reaction was found to be mainly dependent on the hydrophobicity of the catalyst support. It is also significantly affected by the electronic nature of the substrates, by the reaction temperature, and by syngas pressure. The heterogenized catalyst can be reused for several times.

  DOI：

  10.1021/jo402632s

文献信息

• GLYCOPEPTIDE COMPOUNDS HAVING ACTIVITY OF RESISTING DRUG-RESISTANT BACTERIA, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
  申请人：Shanghai LaiYi Center For Biopharmaceutical R&D Co., Ltd.

  公开号：EP3763728A1

  公开（公告）日：2021-01-13

  The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema,

  本发明公开了具有抗耐药性细菌活性的糖肽化合物，符合通式（I）所代表的糖肽化合物、 本发明还提供了糖肽化合物的制备方法和应用。经测试，与第二代糖肽药物奥利他万星（oritavancin）相比，糖肽抗生素化合物对耐药菌株，尤其是 MRSA 或 VRE 具有更高的抑制活性。进一步的测试表明，大多数糖肽化合物的安全性高于奥利他万星，可以制备成药物，用于治疗或预防各种细菌感染引起的疾病，如皮肤和软组织感染、脑膜炎、败血症、肺炎、关节炎、腹膜炎、支气管炎和肺水肿、
• Glycopeptide Compounds Having Activity Of Resisting Drug-Resistant Bacteria, And Preparation Method And Application Thereof
  申请人：Shanghai LaiYi Center For Biopharmaceutical R&D Co

  公开号：US20210093691A1

  公开（公告）日：2021-04-01

  The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.
• Regioselective Hydroaminomethylation of Vinylarenes by a Sol–Gel Immobilized Rhodium Catalyst
  作者：Zackaria Nairoukh、Jochanan Blum

  DOI：10.1021/jo402632s

  日期：2014.3.21

  In the course of our studies toward the development of new heterogeneous conditions for better controlling regioselectivity in organic reactions, we investigated the application of sol-gel immobilized organometallic catalyst for regioselective hydroaminomethylation of vinylarenes with aniline or nitroarene derivatives in an aqueous microemulsion. By immobilization of 6 mol % [Rh(cod)Cl]2 within a hydrophobic silica sol-gel matrix we were able to perform efficient hydroaminomethylation under mild conditions and isolate 2-arylpropylamines with high regioselectivity. The regioselectivity of the reaction was found to be mainly dependent on the hydrophobicity of the catalyst support. It is also significantly affected by the electronic nature of the substrates, by the reaction temperature, and by syngas pressure. The heterogenized catalyst can be reused for several times.