NN'-(4,4'-dichlorodiphenyl)oxamide | 6333-34-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: NN'-(4,4'-dichlorodiphenyl)oxamide
• 英文别名: 4-Cl-C6H4HNCOCONHC6H4-4-Cl；4.4'-Dichlor-oxanilid；N.N'-Bis-(4-chlor-phenyl)-oxalsaeurediamid；N,N'-Di-(4-chlorbenzyl)-oxamid；N,N'-bis-(4-chloro-phenyl)-oxalamide；N,N'-Bis-(4-chlor-phenyl)-oxalamid；N.N'-Bis-(4-chlor-phenyl)-oxamid；Oxalsaeure-bis-(4-chlor-anilid)；(CONHC6H4-4-Cl)2；N,N'-bis(4-chloro-phenyl)-ethanediamide；N,N'-bis(4-chlorophenyl)oxamide
• CAS: 6333-34-2
• 化学式: C₁₄H₁₀Cl₂N₂O₂
• 分子量: 309.152
• InChiKey: GRBNSXNIWBORQH-UHFFFAOYSA-N

物化性质

• 熔点：
  289-291 °C
• 密度：
  1.490±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  NN'-(4,4'-dichlorodiphenyl)oxamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 以82 %的产率得到N,N'-bis-(4-chloro-phenyl)-dithiooxalamide
  参考文献：
  名称：

  带有N,N'-二芳基二草酰胺酯和N,N'-二芳基二硫代草酰胺酯配体的铝配合物在ε-己内酯开环聚合中的比较研究

  摘要：

  本研究合成了一系列具有N , N'-二芳基草酰胺酯和N , N'-二芳基二硫代草酰胺酯配体的Al催化剂，并测定了它们的ε-己内酯聚合速率。在带有N , N '-二芳基二硫代草酰胺酸酯的 Al 配合物中，[Ph H NCS] 2 Al 2 Me 4表现出最高的催化活性（聚ε-己内酯的转化率 = 94%；[ε-己内酯]:[ [ Ph H NCS] 2 Al 2 Me 4 ]:[苯甲醇] = 100:0.5:2，[ε-己内酯] = 2 M，在 25 °C 下 20 分钟后），以及带有 N , N '-二芳基二草酰胺酸酯的Al配合物，[Ph H NCO] 2 Al 2 Me 4表现出最高的催化活性（聚ε-己内酯的转化率 = 94%；[ε-己内酯]:[ O H Al 2 Me 4 ]:[苯甲醇] = 100： 0.5:2，[ε-己内酯] = 2 M，25 °C，30 分钟后）。带有N , N'-二芳

  DOI：

  10.1021/acs.organomet.3c00317
• 作为产物：
  描述：

  草酰苯胺 在 溶剂黄146 作用下， 生成 NN'-(4,4'-dichlorodiphenyl)oxamide
  参考文献：
  名称：

  十九。取代的乙酰胺的卤素衍生物

  摘要：

  DOI：

  10.1039/ct9068900155

文献信息

• Synthesis and characterization of molecular rectangles of half-sandwich p-cymene ruthenium complexes bearing oxamidato ligands
  作者：Wan-Zheng Zhang、Ying-Feng Han、Yue-Jian Lin、Guo-Xin Jin

  DOI：10.1039/b909357e

  日期：——

  A series of binuclear half-sandwich p-cymene ruthenium complexes bearing oxamidato ligands [(p-cymene)2Ru2(μ-N,N′-bis(aryl)oxamidato)Cl2] (1–3) was synthesized by the reactions of the lithium salts of oxamide with [(p-cymene)RuCl2]2, respectively. Treatment of the binuclear complexes (1–3) with bidentate ligands such as 4,4′-bipyridine (4,4′-bpy) and trans-1,2-bis(4-pyridyl)ethylene (bpe) in the presence of AgOTf (OTf = CF3SO3) gave the corresponding tetranuclear complexes generally formulated as [(p-cymene)4Ru4(μ-N,N′- bis(aryl)oxamidato)2(μ-4,4′-bpy)2](OTf)4 (4a–c) and [(p-cymene)4Ru4(μ-N,N′-bis(aryl)oxamidato)2(μ-bpe)2](OTf)4 (5a–c) in high yields. All compounds (1–3, 4a–5c) have been characterized by NMR and IR spectra and elemental analyses. The molecular structures of 1, 4a and 5a have been determined by single-crystal X-ray analyses. The molecular structures of tetranuclear complexes 4a and 5a showed that two binuclear fragments as building blocks were connected by 4,4′-bpy or bpe to construct a rectangular cavity with the dimensions 5.57 × 11.28 Å (4a) and 5.56 × 13.65 Å (5a).

  一系列含有oxamidato配体的双核半三明治结构的二茂铁配合物[(p-cymene)2Ru2(μ-N,N′-双(芳基)oxamidato)Cl2]（1–3）通过oxamide的锂盐与[(p-cymene)RuCl2]2反应合成。在AgOTf (OTf = CF3SO3)存在下，双核配合物（1–3）与二齿配体如4,4′-联吡啶（4,4′-bpy）和反式-1,2-双(4-吡啶基)乙烯（bpe）反应，得到相应的四核配合物，一般表示为[(p-cymene)4Ru4(μ-N,N′-双(芳基)oxamidato)2(μ-4,4′-bpy)2](OTf)4 (4a–c)和[(p-cymene)4Ru4(μ-N,N′-双(芳基)oxamidato)2(μ-bpe)2](OTf)4 (5a–c)，产率较高。所有化合物（1–3, 4a–5c）均通过NMR和IR光谱以及元素分析进行了表征。通过单晶X射线分析确定了1、4a和5a的分子结构。四核配合物4a和5a的分子结构显示，两个双核片段作为构建模块通过4,4′-bpy或bpe连接，形成一个尺寸为5.57 × 11.28 Å（4a）和5.56 × 13.65 Å（5a）的长方形空腔。
• SmI₂Promoted Coupling Reaction of Isocyanates to Oxamides
  作者：Yun-Shan Liu、Mei-Zhi Bei、Zhi-Hua Zhou、Ken Takaki、Yuzo Fujiwara

  DOI：10.1246/cl.1992.1143

  日期：1992.7

  Oxamides were obtained in moderate to good yields by the reaction of isocyanates with the SmI2/HMPA/THF system under mild conditions. The system also caused desulfurization of isothiocyanates to give isocyanides in good yields.

  在温和条件下，利用异氰酸酯与SmI2/HMPA/THF体系反应，可以中等至良好产率获得草酰胺。该体系还能引发异硫氰酸酯的去硫反应，良好产率地生成异氰化物。
• Reaction pathways for arylcarbamoyl radicals and the cyclization of o-substituted phenylcarbamoyl radicals
  作者：Rino Leardini、Antonio Tundo、Giuseppe Zanardi

  DOI：10.1039/p19810003164

  日期：——

  in the aromatic ring. When the aryl group is phenyl or p-chlorophenyl the following reactions on carbamoyl radicals occur: (i) loss of hydrogen with formation of aryl isocyanates, whereas the loss of carbon monoxide leads to arylamines via arylaminyl radicals; (ii) dimerization to NN′-diaryloxamides; (iii) aromatic substitution on chlorbenzene leading to N-arylbenzamides (ipso-substitution) and N-

  ñ从产生自由基-Arylcarbamoyl Ñ与二叔丁基过氧化物（BU -arylformamides吨OOBu吨）的氯苯在110℃下产生一系列取决于性质和取代基中的芳环中的位置反应。当芳基是苯基或对氯苯基时，在氨基甲酰基上发生以下反应：（i）氢损失并形成芳基异氰酸酯，而一氧化碳的损失通过芳基芳基导致芳胺；（II）二聚NN '-diaryloxamides; （iii）氯苯上的芳香取代导致N-arylbenzamides（本位3'-取代）和Ñ -arylchlorobenzamides。由叔丁醇和芳基胺捕集的异氰酸酯给予叔丁基Ñ -arylcarbamates和NN '-diarylureas。用o-取代的N-苯基甲酰胺也观察到分子内环化。实际上，N-（邻-氰基苯基）甲酰胺通过将氨基甲酰基加成到氰基上来提供靛红，而N -[（邻-苯硫基）苯基]甲酰胺通过S H i生成2-苯并噻唑酮和苯基。在
• METHOD FOR CONVERTING HYDROXYL GROUP OF ALCOHOL
  申请人：Takasago International Corporation

  公开号：US20210047254A1

  公开（公告）日：2021-02-18

  The present invention relates to: a method for converting a hydroxyl group of an alcohol; and a catalyst which makes the method possible. A method for converting a hydroxyl group of an alcohol according to the present invention is characterized by producing a compound represented by CH(R 1 )(R 2 )Nu (wherein R 1 , R 2 and Nu are as defined below) by reacting an alcohol represented by CH(R 1 )(R 2 )OH (wherein each of R 1 and R 2 represents a hydrogen atom, an optionally substituted alkyl group, or the like) and a compound having an active proton, which is represented by H-Nu (wherein Nu represents a group represented by —CHX 1 -EWG 1 or —NR 3 R 4 ; X 1 represents a hydrogen atom or the like; EWG 1 represents an electron-withdrawing group; and each of R 3 and R 4 represents a hydrogen atom, an optionally substituted alkyl group, or the like), with each other in the presence of a complex of a group 7-11 metal of the periodic table and at least one solid base that is selected from the group consisting of layered double hydroxides, composite oxides and calcium hydroxide.

  本发明涉及：将醇的羟基转化为的方法；以及使该方法成为可能的催化剂。根据本发明的将醇的羟基转化为的方法的特征在于，在周期表的7-11族金属群的复合物存在下，通过将一个由CH(R1)(R2)OH（其中R1和R2分别表示氢原子、可选择取代的烷基基团或类似物）表示的醇与一个具有活性质子的化合物（其中Nu表示由—CHX1-EWG1或—NR3R4表示的基团；X1表示氢原子或类似物；EWG1表示电子吸引基团；R3和R4分别表示氢原子、可选择取代的烷基基团或类似物）反应，从而产生一个由CH(R1)(R2)Nu（其中R1、R2和Nu如下定义）表示的化合物。同时，所述反应中至少选择一种来自层状双氢氧化物、复合氧化物和氢氧化钙的固体碱作为催化剂。
• Tuning the Reactivity of Cofacial Porphyrin Prisms for Oxygen Reduction Using Modular Building Blocks
  作者：Matthew R. Crawley、Daoyang Zhang、Amanda N. Oldacre、Christine M. Beavers、Alan E. Friedman、Timothy R. Cook

  DOI：10.1021/jacs.0c11895

  日期：2021.1.20

  assembled eight cofacial porphyrin prisms using MTPyP (M = Co(II) or Zn(II), TPyP = 4-tetrapyridylporphyrin) and functionalized ruthenium-based "molecular clips" using coordination-driven self-assembly. Our approach allows for the rapid synthesis of these architectures in isolated yields as high as 98% for the assembly step. Structural and reactivity studies provided a deeper understanding of the role of

  我们使用 MTPyP（M = Co(II) 或 Zn(II)，TPyP = 4-四吡啶基卟啉）组装了八个面卟啉棱镜，并使用协调驱动的自组装功能化了基于钌的“分子夹”。我们的方法允许在组装步骤中以高达 98% 的孤立产量快速合成这些架构。结构和反应性研究提供了对构建块对氧还原反应 (ORR) 作用的更深入理解。通过在水性介质中的非均相催化剂油墨上使用循环伏安法和流体动力学伏安法来探测催化功效。与动力学上更容易接近的 2e-/2H+ 还原为 H2O2 相比，所报告的棱镜对 O2 到 H2O 的动力学受阻 4e-/4H+ 还原显示出出色的选择性 (>98%)。此外，我们已经证明观察到的催化速率常数 ks（~5 个数量级）比单核类似物显着增强。我们得出结论，夹子的立体体积在这些棱镜的结构动力学中起着重要作用，这反过来又会调节 ORR 反应性的选择性和动力学。