methyl 3-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzoate | 1349171-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzoate
• 英文别名: methyl 3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzoate；methyl 3-[(3,5-dimethylpyrazol-1-yl)methyl]benzoate
• CAS: 1349171-59-0
• 化学式: C₁₄H₁₆N₂O₂
• 分子量: 244.293
• InChiKey: YNUYBDGRXGCBDA-UHFFFAOYSA-N

物化性质

• 沸点：
  392.5±42.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 3-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzoate 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 sodium hydroxide 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.08h， 生成 ethyl 4-(3-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzamido)-1-ethyl-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

  摘要：

  Hypoxia-inducible factor (HIF)-1 is well known as a promising target for cancer chemotherapy. By screening an in-house chemical library using a hypoxia-responsive luciferase reporter gene assay, we identified CLB-016 (1) containing 1-ethylpyrazole-3-carboxamide as a HIF-1 inhibitor (IC50 = 19.1 mu M). In a subsequent extensive structure-activity relationship (SAR) study, we developed compound 11Ae with an IC50 value of 8.1 mu M against HIF-1-driven luciferase activity. Compounds 1 and 11Ae were shown to significantly suppress the HIF-1-mediated hypoxia response, including carbonic anhydrase IX (CAIX) gene expression and migration of human sarcoma HT1080 cells. These results revealed 1-ethylpyrazole-3-carboxamide as a novel scaffold to develop promising anti-cancer drugs targeting the HIF-1 signaling pathway. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.02.038
• 作为产物：
  描述：

  3,5-二甲基吡唑 、 3-氯甲基苯甲酸甲酯 在 potassium tert-butylate 、 四丁基碘化铵 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 methyl 3-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)benzoate
  参考文献：
  名称：

  Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

  摘要：

  Hypoxia-inducible factor (HIF)-1 is well known as a promising target for cancer chemotherapy. By screening an in-house chemical library using a hypoxia-responsive luciferase reporter gene assay, we identified CLB-016 (1) containing 1-ethylpyrazole-3-carboxamide as a HIF-1 inhibitor (IC50 = 19.1 mu M). In a subsequent extensive structure-activity relationship (SAR) study, we developed compound 11Ae with an IC50 value of 8.1 mu M against HIF-1-driven luciferase activity. Compounds 1 and 11Ae were shown to significantly suppress the HIF-1-mediated hypoxia response, including carbonic anhydrase IX (CAIX) gene expression and migration of human sarcoma HT1080 cells. These results revealed 1-ethylpyrazole-3-carboxamide as a novel scaffold to develop promising anti-cancer drugs targeting the HIF-1 signaling pathway. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.02.038

文献信息

• 10.1080/14756366.2024.2353711
  作者：Wu, Tingting、Cheng, Hu、Sima, Lijie、Wang, Zhongyuan、Ouyang, Weiwei、Wang, Jianta、Hou, Yunlei、Zhao, Dongsheng、Liao, Weike、Hu, Chujiao

  DOI：10.1080/14756366.2024.2353711

  日期：——

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  PD-1/PD-L1 通路被认为是肿瘤免疫治疗中最有前途的免疫检查点之一。然而，研究人员面临着抗体的固有局限性，推动了...
• Rh-Catalyzed <i>Ortho</i>-Selective C–H Borylation of <i>N</i>-Functionalized Arenes with Silica-Supported Bridgehead Monophosphine Ligands
  作者：Soichiro Kawamorita、Tatsuya Miyazaki、Hirohisa Ohmiya、Tomohiro Iwai、Masaya Sawamura

  DOI：10.1021/ja208364a

  日期：2011.12.7

  Supported phosphine-Rh systems, prepared in situ from silica-supported bridgehead monophosphines and [Rh(OH)(cod)]2, have enabled ortho-selective C-H borylation for a range of arenes containing nitrogen-based directing groups. The regioselectivity was excellent with various N-directing groups, including saturated and unsaturated N-heterocycles, tert-aminoalkyl groups, and iminetype C-N double bonds. The reaction showed significant tolerance toward steric repulsion around the reacting C-H bond. This Rh catalysis complements the Jr-catalyzed orthoborylation, which is effective for arenes with oxygen-based directing groups.
• Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors
  作者：Yorinobu Yasuda、Takeaki Arakawa、Yumi Nawata、Sayaka Shimada、Shinya Oishi、Nobutaka Fujii、Shinichi Nishimura、Akira Hattori、Hideaki Kakeya

  DOI：10.1016/j.bmc.2015.02.038

  日期：2015.4

  Hypoxia-inducible factor (HIF)-1 is well known as a promising target for cancer chemotherapy. By screening an in-house chemical library using a hypoxia-responsive luciferase reporter gene assay, we identified CLB-016 (1) containing 1-ethylpyrazole-3-carboxamide as a HIF-1 inhibitor (IC50 = 19.1 mu M). In a subsequent extensive structure-activity relationship (SAR) study, we developed compound 11Ae with an IC50 value of 8.1 mu M against HIF-1-driven luciferase activity. Compounds 1 and 11Ae were shown to significantly suppress the HIF-1-mediated hypoxia response, including carbonic anhydrase IX (CAIX) gene expression and migration of human sarcoma HT1080 cells. These results revealed 1-ethylpyrazole-3-carboxamide as a novel scaffold to develop promising anti-cancer drugs targeting the HIF-1 signaling pathway. (C) 2015 Elsevier Ltd. All rights reserved.