2-(4-Methyl-thiazol-2-ylmethyl)-pyridine | 51451-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-Methyl-thiazol-2-ylmethyl)-pyridine
• 英文别名: 4-Methyl-2-(pyridin-2-ylmethyl)thiazole；4-methyl-2-(pyridin-2-ylmethyl)-1,3-thiazole
• CAS: 51451-48-0
• 化学式: C₁₀H₁₀N₂S
• 分子量: 190.269
• InChiKey: YKMZZWADKYKWAT-UHFFFAOYSA-N

物化性质

• 沸点：
  320.3±30.0 °C(Predicted)
• 密度：
  1.181±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴吡啶 、 2,4-二甲基噻唑 在 potassium amide 作用下， 生成 2-氨基吡啶 、 2-(4-Methyl-thiazol-2-ylmethyl)-pyridine 、 4,4'-dimethyl-2,2'-ethane-1,2-diyl-bis-thiazole
  参考文献：
  名称：

  Compatibility of Various Carbanion Nucleophiles with Heteroaromatic Nucleophilic Substitution by the S_RN1 Mechanism

  摘要：

  Carbanions generated from 2,4,4-trimethyl-2-oxazoline (1a), 2-benzyl-4,4-dimethyl-2-oxazoline (1b), 2,4-dimethylthiazole (13a), 2-benzyl-4-methylthiazole (13b), N,N-dimethylacetamide (17a), tert-butyl acetate (17b), ethyl phenylacetate (17c), N-methyl-N-phenyl-2-butenamide (22), tert-butyl 3-butenoate (25), and dimethyl methylphosphonate (29a) by means of KNH2 in liquid NH3 all reacted with 2-bromopyridine (2) via photoassisted reactions that exhibited characteristics of the S(RN)1 mechanism. Similar results were obtained in reactions of these carbanions with other substrates, including 2-chloroquinoline (6), iodobenzene (9), bromobenzene (10), and bromomesitylene (11).

  DOI：

  10.1021/jo962353f