2,2,6-Trimethylpimelinsaeure | 49714-22-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,6-Trimethylpimelinsaeure
• 英文别名: 2,2,6-trimethyl-heptanedioic acid；2,2,6-Trimethyl-heptandisaeure；2,2,6-Trimethylheptanedioic acid；2,2,6-trimethylheptanedioic acid
• CAS: 49714-22-9
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: ALDJHLVQRSXLNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3,3-trimethyl-2-oxo-cyclohexanecarboxylic acid methyl ester 在 甲醇 、 sodium methylate 作用下， 生成 2,2,6-Trimethylpimelinsaeure
  参考文献：
  名称：

  Preparation of a Grignard Reagent Containing a Carbonyl Group

  摘要：

  DOI：

  10.1021/jo50005a012

文献信息

• New Strategy for Forging Contiguous Quaternary Carbon Centers via H2O2-Mediated Ring Contraction
  作者：Weiqing Xie、Jiadong Hu、Xin Yu

  DOI：10.1055/s-0036-1590979

  日期：2017.12

  product synthesis. A general protocol that enables stereospecific construction of all stereoisomers of such a moiety remains elusive. In this article, we will discuss the oxidative ring contraction of all-substituted cyclic α-formyl ketones mediated by H2O2, which provides a facile access to the stereospecific construction of contiguous quaternary carbon centers.

  连续四元碳中心的立体有择构建构成了天然产物合成的主要挑战。使这种部分的所有立体异构体的立体特异性构建成为可能的通用协议仍然难以捉摸。在本文中，我们将讨论由 H2O2 介导的全取代环状 α-甲酰基酮的氧化环收缩，这为连续季碳中心的立体有择构建提供了便利。
• Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction
  作者：Xin Yu、Jiadong Hu、Zhigao Shen、Hui Zhang、Jin-Ming Gao、Weiqing Xie

  DOI：10.1002/anie.201609975

  日期：2017.1.2

  ketones was facilitated by the action of H2O2 under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all‐carbon centers from stereodefined all‐substituted all‐cyclic ketones. The asymmetric syntheses of (+)‐cuparene and (+)‐tochuinyl acetate were also successively achieved by taking advantage

  在操作简单和环境友好的反应条件下，H 2 O 2的作用促进了环状α-甲酰基酮的氧化环收缩。该过程具有高度的区域选择性，并能够从立体定义的全取代的全环酮立体构筑连续的季碳全碳中心。利用该新方案还成功实现了（+）-cuparene和（+）-tochuinyl乙酸酯的不对称合成。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND
  申请人：Komiyama Masato

  公开号：US20130158272A1

  公开（公告）日：2013-06-20

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C 1 -C 40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产黄嘌呤氧化酶抑制剂的方法，该抑制剂是治疗高尿酸血症的药物，或者其中间体，该方法高效且使用流程简短。本发明是一种新型耦合方法，通过在钯化合物、能够配位到钯化合物的配体、碱、C1-C40羧酸和至少一种添加剂的存在下，在式（1）所代表的化合物和式（2）所代表的化合物之间引发耦合反应，从而获得式（3）所代表的化合物。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND
  申请人：Teijin Pharma Limited

  公开号：EP2610248A1

  公开（公告）日：2013-07-03

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C1-C40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产作为高尿酸血症治疗药物的黄嘌呤氧化酶抑制剂或其中间体的方法，所述方法高效且工艺流程短。本发明是一种新颖的偶联方法，通过在钯化合物、能与钯化合物配位的配体、碱、C1-C40 羧酸和至少一种添加剂存在下，使式（1）代表的化合物与式（2）代表的化合物发生偶联反应，得到式（3）代表的化合物。
• Berzin,V.B. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, p. 1466 - 1472
  作者：Berzin,V.B. et al.

  DOI：——

  日期：——