2-(4-溴苯基氨基)-N-甲基乙酰胺 | 1020989-19-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(4-溴苯基氨基)-N-甲基乙酰胺
• 英文名称: 2-(4-bromophenylamino)-N-methylacetamide
• 英文别名: 2-(4-bromoanilino)-N-methylacetamide
• CAS: 1020989-19-8
• 化学式: C₉H₁₁BrN₂O
• mdl: MFCD11153125
• 分子量: 243.103
• InChiKey: ALRUDXRKNFBRCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  烯丙基三甲氧基硅烷 、 2-(4-溴苯基氨基)-N-甲基乙酰胺 在 silver trifluoromethanesulfonate 、 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 以67%的产率得到2-((4-bromophenyl)amino)-N-methylpent-4-enamide
  参考文献：
  名称：

  A silver triflate-catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines

  摘要：

  A silver-triflate catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines is reported. The 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate is employed as a mild oxidant which is compatible with both catalyst and ligand. Racemic BINAP is also utilized to assist with the catalyst in regulating the yields of products. Various homoallylic amines are obtained in 39-99% yields. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2016.06.076
• 作为产物：
  描述：

  2-溴-N-甲基乙酰胺 、 4-溴苯胺 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 2-(4-溴苯基氨基)-N-甲基乙酰胺
  参考文献：
  名称：

  A silver triflate-catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines

  摘要：

  A silver-triflate catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines is reported. The 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate is employed as a mild oxidant which is compatible with both catalyst and ligand. Racemic BINAP is also utilized to assist with the catalyst in regulating the yields of products. Various homoallylic amines are obtained in 39-99% yields. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2016.06.076

文献信息

• [EN] CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE LA CÉRAMIDE GALACTOSYLTRANSFÉRASE POUR LE TRAITEMENT DE MALADIES
  申请人：BIOMARIN PHARM INC

  公开号：WO2017214505A1

  公开（公告）日：2017-12-14

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物、以及使用这种化合物治疗或预防与酶神经鞘糖脂转移酶（CGT）相关的疾病或紊乱的方法，例如溶酶体贮积症。溶酶体贮积症的例子包括 Krabbe 病和白质变性白血病。
• Catalytic sp³ C–H Oxidation of Peptides and Their Analogues by Radical Cation Salts: From Glycine Amides to Quinolines
  作者：Xiaodong Jia、Yaxin Wang、Fangfang Peng、Congde Huo、Liangliang Yu、Jing Liu、Xicun Wang

  DOI：10.1021/jo401018v

  日期：2013.9.20

  A catalytic α-sp3 C–H oxidation of peptides and glycine amides was achieved under radical cation salt catalysis in the presence of O2, producing a series of substituted quinolines. The scope of this reaction shows good functional group tolerance and high efficiency of the oxidative functionalization.

  一种催化α-SP 3肽和甘氨酸酰胺的C-H的氧化是在的O-存在下自由基阳离子盐催化达到2，生产了一系列取代的喹啉的。该反应的范围显示出良好的官能团耐受性和氧化官能化的高效率。
• A silver triflate-catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines
  作者：Junjiao Wang、Shangdong Yang

  DOI：10.1016/j.tetlet.2016.06.076

  日期：2016.8

  A silver-triflate catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines is reported. The 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate is employed as a mild oxidant which is compatible with both catalyst and ligand. Racemic BINAP is also utilized to assist with the catalyst in regulating the yields of products. Various homoallylic amines are obtained in 39-99% yields. (C) 2016 Elsevier Ltd. All rights reserved.