2-methoxy-2-methylhexanoic acid | 232940-56-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methoxy-2-methylhexanoic acid
• CAS: 232940-56-6
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: IWTGMVSCEOXQTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-2-methylhexanoic acid 在 盐酸 作用下， 生成 (R)-2-Methoxy-2-methyl-hexanoic acid methyl ester
  参考文献：
  名称：

  16-甲氧基-16-甲基前列腺素的结构活性研究。

  摘要：

  描述了16-甲氧基-16-甲基-PGF2α，-PGE2和-PGE1的纯非对映异构体的合成。C-16的绝对构型通过化学方法确定，而非对映异构体的绝对C-15构型根据其色谱行为和NMR光谱暂定。评价合成的前列腺素类似物的抗分泌，抗生育和腹泻作用。发现C-15和C-16构型对于生物活性都是至关重要的。这些研究表明，将C-16处的甲基和甲氧基引入到前列腺素类似物中明显增加了抗分泌与腹泻作用的比率。PGE1衍生物之一9f（15 alpha，16R）（MDL646 mexiprostil），

  DOI：

  10.1021/jm00160a005
• 作为产物：
  描述：

  2-hydroxy-2-methylhexanenitrile 在 盐酸 、 sodium hydroxide 、 sodium hydride 作用下， 以 乙醇 为溶剂， 反应 3.5h， 生成 2-methoxy-2-methylhexanoic acid
  参考文献：
  名称：

  16-甲氧基-16-甲基前列腺素的结构活性研究。

  摘要：

  描述了16-甲氧基-16-甲基-PGF2α，-PGE2和-PGE1的纯非对映异构体的合成。C-16的绝对构型通过化学方法确定，而非对映异构体的绝对C-15构型根据其色谱行为和NMR光谱暂定。评价合成的前列腺素类似物的抗分泌，抗生育和腹泻作用。发现C-15和C-16构型对于生物活性都是至关重要的。这些研究表明，将C-16处的甲基和甲氧基引入到前列腺素类似物中明显增加了抗分泌与腹泻作用的比率。PGE1衍生物之一9f（15 alpha，16R）（MDL646 mexiprostil），

  DOI：

  10.1021/jm00160a005

文献信息

• Phenylglycine Methyl Ester, a Useful Tool for Absolute Configuration Determination of Various Chiral Carboxylic Acids
  作者：Tetsuya Yabuuchi、Takenori Kusumi

  DOI：10.1021/jo991218a

  日期：2000.1.1

  A new chiral anisotropic reagent, phenylglycine methyl ester (PGME), developed for the elucidation of the absolute configuration of chiral alpha,alpha-disubstituted acetic acids, has turned out to be applicable to other substituted carboxylic acids, such as chiral alpha-hydroxy-, alpha-alkoxy-, and alpha-acyloxy-alpha, alpha-disubstituted acetic acids, as well as to chiral beta, beta-disubstituted

  为了阐明手性α，α-二取代乙酸的绝对构型而开发的一种新的手性各向异性试剂苯甘氨酸甲酯（PGME）已证明可用于其他取代的羧酸，例如手性α-羟基- ，α-烷氧基-和α-酰氧基-α，α-二取代的乙酸，以及手性β，β-二取代的丙酸。由于羧基部分可从其他官能团转化而来，例如烯烃的臭氧分解和二醇的氧化裂解，因此，本发现可将PGME方法的用途扩展到各种类型有机化合物的绝对构型测定，甚至那些最初缺乏氧气功能。描述了化学反应和PGME方法结合的几个例子。
• A Convenient One-Pot Synthesis of Quaternary .ALPHA.-Methoxy- and .ALPHA.-Hydroxycarboxylic Acids.
  作者：Tetsuya YABUUCHI、Takenori KUSUMI

  DOI：10.1248/cpb.47.684

  日期：——

  Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in methanol and water, respectively, in good yields.

  通过一种新型的一锅法合成，使用了酮、三溴甲烷和氢氧化钾分别在甲醇和水中的条件下，成功合成了数种α-甲氧基和α-羟基羧酸，产率良好。
• Surface active agent containing fluorine and coating compositions using the same
  申请人：Dainippon Ink. and Chemicals, Inc.

  公开号：US20020103316A1

  公开（公告）日：2002-08-01

  The invention provides a surface active agent containing fluorine, which is a copolymer composed of several ethylenic unsaturated monomers containing a fluorinated alkyl group, a silicone chain, and a polyoxyalkylene group, and the surface loss energy of which is less than 110×10 −5 mJ in an organic solvent. The copolymer of the surface active agent is soluble to water and in various organic solvents, and has a good compatibility with other ingredients used to form the coating compositions. The present surface active agent reduces the dynamic surface tension of the coating composition, and thereby, have a good foam-preventing property, coating compositions containing the present surface active agent yield coated films with uniform and smooth level surfaces without forming irregularity and striation even by coating operations at high speed and high shearing force.

  本发明提供了一种含氟表面活性剂，它是由含有氟化烷基、硅酮链和聚氧亚烷基的几种乙烯基不饱和单体组成的共聚物，其表面损失能小于 110×10 -5 mJ。表面活性剂的共聚物可溶于水和各种有机溶剂，与用于形成涂料组合物的其他成分具有良好的相容性。本表面活性剂可降低涂料组合物的动态表面张力，从而具有良好的防泡沫性能，即使在高速和高剪切力下进行涂布操作，含有本表面活性剂的涂料组合物也能生成表面均匀光滑平整的涂膜，而不会形成不规则和条纹。
• Golf ball
  申请人：Okabe Satoko

  公开号：US20060287133A1

  公开（公告）日：2006-12-21

  The object of the present invention is to provide a golf ball having the individualized appearance as well as the improved visibility, which the mark should inherently provide, by imparting the luster (brilliance) to the mark, without lowering the durability of the mark, even if the mark is printed with the ink composition which the luster material is blended into. The golf ball of the present invention comprises a mark made from an ink composition, wherein the ink composition comprises a pigment, and a luster material having a core layer with a smooth surface and a metal covering the core layer.
• GOLF BALL
  申请人：OKABE Satoko

  公开号：US20100222159A1

  公开（公告）日：2010-09-02

  The object of the present invention is to provide a golf ball having the individualized appearance as well as the improved visibility, which the mark should inherently provide, by imparting the luster (brilliance) to the mark, without lowering the durability of the mark. The golf ball of the present invention comprises a mark on a golf ball body, wherein the mark is made from an ink composition that comprises a luster material including a bismuth-containing compound, and a pigment.