4-Amino-1-(p-tolyl)-5-imidazolcarbonsaeure-ethylesther | 110718-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Amino-1-(p-tolyl)-5-imidazolcarbonsaeure-ethylesther
• 英文别名: Ethyl 5-amino-3-(4-methylphenyl)imidazole-4-carboxylate
• CAS: 110718-95-1
• 化学式: C₁₃H₁₅N₃O₂
• 分子量: 245.281
• InChiKey: AUPUHYZBHFVDLG-UHFFFAOYSA-N

物化性质

• 熔点：
  122 °C(Solv: ethanol (64-17-5))
• 沸点：
  424.4±35.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Amino-1-(p-tolyl)-5-imidazolcarbonsaeure-ethylesther 、 硫代乙酰胺 在 甲酸 作用下， 反应 4.0h， 以85%的产率得到2-Methyl-7-(p-tolyl)hypoxanthin
  参考文献：
  名称：

  Verkoyen, Carl; Golovinsky, Evgeny; Mueller, Gunther, Liebigs Annalen der Chemie, 1987, p. 957 - 960

  摘要：

  DOI：

文献信息

• VERKOYEN, CARL;GOLOVINSKY, EVGENY;MULLER, GUNTHER;KOLBEL, MARGIT;NORPOTH,+, LIEBIGS ANN. CHEM.,(1987) N 11, 957-960
  作者：VERKOYEN, CARL、GOLOVINSKY, EVGENY、MULLER, GUNTHER、KOLBEL, MARGIT、NORPOTH,+

  DOI：——

  日期：——
• Myogenesis Promotor, Muscle Atrophy Inhibitor, Medical Composition and Taz Activator
  申请人：NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY

  公开号：US20160346251A1

  公开（公告）日：2016-12-01

  The invention provides a novel myogenesis promotor, a novel muscle atrophy inhibitor, a novel composition or a novel TAZ activator. The myogenesis promotor, the muscle atrophy inhibitor, the composition and the TAZ activator include a composition represented by the following Formula (I) as an active ingredient. In Formula (I), R 1 represents a hydrogen atom or an alkyl group; R 2 represents an aryl group, a heterocyclic group, an alkyl group or the like; R 3 represents —NR 5 R 6 or —N═C—R 7 ; each of R 5 and R 6 independently represents a hydrogen atom, an alkyl group or the like; R 7 represents —NR 10 R 11 , an aryl group or a heterocyclic group; R 8 represents a hydrogen atom, an alkyl group or the like; R 9 represents a hydrogen atom, an alkyl group or the like; each of R 10 and R 11 independently represents a hydrogen atom, an alkyl group or the like; R 4 represents a cyano group or —C(═O)R 12 ; and R 12 represents an aryl group, a heterocyclic group, an alkyl group or the like.