Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions
作者:Xiang Liu、Dan Song、Zemin Zhang、Jiatong Lin、Canzhan Zhuang、Haiying Zhan、Hua Cao
DOI:10.1039/d1ob00701g
日期:——
disulfide has been described. A series of indolizine-dithiocarbamate derivatives were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in
已经描述了用四烷基秋兰姆二硫化物对中氮茚进行有效且直接的无金属区域选择性 C-H 二硫代氨基甲酸化。一系列中氮茚-二硫代氨基甲酸酯衍生物很容易以中等至良好的收率获得,范围广泛。此外,咪唑并[1,2 - a ]吡啶也具有良好的耐受性,可提供多种咪唑杂环-二硫代氨基甲酸酯产品,有望用于药物发现。值得注意的是,该反应可以很容易地放大,并显示出其在有机合成中的实用价值。