[2-Benzoyloxy-4-bis(trimethylsilyloxy)phosphorylbutyl] benzoate | 926021-55-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-Benzoyloxy-4-bis(trimethylsilyloxy)phosphorylbutyl] benzoate
• CAS: 926021-55-8
• 化学式: C₂₄H₃₅O₇PSi₂
• 分子量: 522.682
• InChiKey: KFIZOXBMOQFOFT-UHFFFAOYSA-N

物化性质

• 沸点：
  547.2±60.0 °C(Predicted)
• 密度：
  1.119±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.36
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [2-Benzoyloxy-4-bis(trimethylsilyloxy)phosphorylbutyl] benzoate 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 (2-benzoyloxy-4-dichlorophosphorylbutyl) benzoate
  参考文献：
  名称：

  Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants

  摘要：

  The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs wore measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.083
• 作为产物：
  描述：

  2,3-环氧丙基苯甲酸酯 在 4-二甲氨基吡啶 、 正丁基锂 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.67h， 生成 [2-Benzoyloxy-4-bis(trimethylsilyloxy)phosphorylbutyl] benzoate
  参考文献：
  名称：

  Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants

  摘要：

  The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs wore measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.083

文献信息

• WO2008/11559
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and surface activity of diether-linked phosphoglycerols: Potential applications for exogenous lung surfactants
  作者：Robert H. Notter、Zhongyi Wang、Zhengdong Wang、Jason A. Davy、Adrian L. Schwan

  DOI：10.1016/j.bmcl.2006.09.083

  日期：2007.1

  The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs wore measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants. (c) 2006 Elsevier Ltd. All rights reserved.