N-(tert-butyl)-2-(2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine | 1381726-48-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(tert-butyl)-2-(2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine
• 英文别名: N-tert-butyl-2-(2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine
• CAS: 1381726-48-2
• 化学式: C₁₇H₂₀N₄O
• 分子量: 296.372
• InChiKey: QSDGFXMCNUBTKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  51.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氨基吡嗪 、 异氰酸叔丁酯 、 邻甲氧基苯甲醛 在 lanthanum chloride heptahydrate 作用下， 以 neat (no solvent) 为溶剂， 反应 1.0h， 以93%的产率得到N-(tert-butyl)-2-(2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine
  参考文献：
  名称：

  A highly efficient synthesis of imidazo-fused polyheterocycles via Groebke–Blackburn–Bienaymè reaction catalyzed by LaCl3·7H2O

  摘要：

  A highly efficient and mild protocol for the synthesis of imidazo-fused polyheterocycles via Groebke-Blackburn-Bienayme reaction under the influence of catalytic amount of lanthanum chloride heptahydrate has been described. A wide range of nitrogen-enriched polyheterocycles are synthesized with high yields under neat conditions. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.08.126

文献信息

• A highly efficient synthesis of imidazo-fused polyheterocycles via Groebke–Blackburn–Bienaymè reaction catalyzed by LaCl3·7H2O
  作者：Anand H. Shinde、Malipatel Srilaxmi、Bishnupada Satpathi、Duddu S. Sharada

  DOI：10.1016/j.tetlet.2014.08.126

  日期：2014.10

  A highly efficient and mild protocol for the synthesis of imidazo-fused polyheterocycles via Groebke-Blackburn-Bienayme reaction under the influence of catalytic amount of lanthanum chloride heptahydrate has been described. A wide range of nitrogen-enriched polyheterocycles are synthesized with high yields under neat conditions. (C) 2014 Elsevier Ltd. All rights reserved.