2,2,4,4-Tetramethylhexanedioic acid | 25162-95-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,4,4-Tetramethylhexanedioic acid
• 英文别名: 2,2,4,4-Tetramethyl-hexan-disaeure；2,2,4,4-Tetramethyl-adipinsaeure
• CAS: 25162-95-2
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: QMBXZRDJYFMVIH-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C(Solv: water (7732-18-5))
• 沸点：
  122 °C(Press: 3 Torr)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2,4,4-Tetramethylhexanedioic acid 在 barium dihydroxide 、 manganese(II)carbonate 作用下， 生成 2,2,4,4-四甲基环戊酮
  参考文献：
  名称：

  Cyclopentenes and Cyclopentanes. II. Synthesis from Isophorone¹

  摘要：

  DOI：

  10.1021/jo01074a008
• 作为产物：
  描述：

  3,3,5,5-四甲基环己酮 在 ammonium metavanadate 、 硝酸 作用下， 生成 2,2,4,4-Tetramethylhexanedioic acid
  参考文献：
  名称：

  Cyclopentenes and Cyclopentanes. II. Synthesis from Isophorone¹

  摘要：

  DOI：

  10.1021/jo01074a008

文献信息

• A New Oxidative Cleavage of 2-Nitrocycloalkanones by Hydrogen Peroxide: An Important, Efficient Method for Dicarboxylic Acid or Ketoacid Synthesis
  作者：Roberto Ballini、Enrico Marcantoni、Marino Petrini、Goffredo Rosini

  DOI：10.1055/s-1988-27754

  日期：——

  2-Nitrocycloalkanones are smoothly converted into dicarboxylic acids or ketoacids, depending on whether the nitro group is secondary or tertiary, by treatment with aqueous 30% hydrogen peroxide and potassium carbonate in methyl alcohol solution for 8-10h at room temperature.

  2-硝基环烷酮在室温下用30%过氧化氢和碳酸钾在甲醇溶液中处理8-10小时后，会顺利转化为二羧酸或酮酸，具体取决于硝基的类型是二级还是三级。
• Environmental friendly well treatment fluids comprising an ester
  申请人：AMRIL AG

  公开号：US10253236B2

  公开（公告）日：2019-04-09

  The present invention relates to environmental friendly well treatment fluids comprising water and/or an organic phase and an ester obtainable by reacting a polycarboxylic acid with a hydroxy monocarboxylic acid. The invention also relates to the use of said ester as viscosifier and/or corrosion inhibitor for a well treatment fluid and preferably for a well treatment fluid for offshore well drilling.

  本发明涉及环境友好型油井处理液，包括水和/或有机相以及通过聚羧酸与羟基一元羧酸反应获得的酯。本发明还涉及将上述酯类用作油井处理液的增粘剂和/或缓蚀剂，最好是用于近海钻井的油井处理液。
• Polymer-carbohydrate conjugates for drug delivery technology
  申请人：Wu Nian

  公开号：US10835608B2

  公开（公告）日：2020-11-17

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.

  本发明包括化合物、制造方法和使用方法。这些化合物可具有线性或环状骨架和三个或四个附加官能团：一个或两个亲脂化合物（包括甾醇或 "脂溶性 "维生素）、一个或两个亲水性聚合物以及一个或两个碳水化合物。已公开的一组聚合物-碳水化合物共轭物具有一个中心骨架和三个附加官能团，其中一种亲脂化合物不含两种甾醇酸。共轭物可以脂肪酸为主要亲脂载体，一种亲水性聚合物和一种碳水化合物。可以选择特定的官能团，用于配制药品、化妆品、营养品等。共轭物的典型偶联反应可能涉及一种或多种烷基化反应，或其组合或系列烷基化反应，包括 N-烷基化反应或 O-烷基化反应、醚化反应、酯化反应和酰胺化反应等化学过程。还可在骨架和官能团之间选择各种连接物，以修饰用于偶联反应的载体或中心骨架，优化共轭物的性能。
• Cavill,G.W.K.; Solomon,D.H., Australian Journal of Chemistry, 1962, vol. 15, p. 764 - 770
  作者：Cavill,G.W.K.、Solomon,D.H.

  DOI：——

  日期：——
• ANTI-ANGIOGENIC COMPOUNDS
  申请人：Doppalapudi Venkata Ramana

  公开号：US20120321591A1

  公开（公告）日：2012-12-20

  The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules