4,5-bis(4-fluorophenyl)-1H-2-(2-pyridyl)imidazole | 1201275-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4,5-bis(4-fluorophenyl)-1H-2-(2-pyridyl)imidazole
• 英文别名: 2-(4,5-Bis(4-fluorophenyl)-1H-imidazol-2-yl)pyridine；2-[4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl]pyridine
• CAS: 1201275-24-2
• 化学式: C₂₀H₁₃F₂N₃
• 分子量: 333.34
• InChiKey: XATUJEWBYDRHHE-UHFFFAOYSA-N

物化性质

• 熔点：
  234-235 °C
• 沸点：
  525.4±45.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氰基吡啶 、 对氟苯甲醛 在 ammonium acetate 作用下， 反应 0.33h， 以84%的产率得到4,5-bis(4-fluorophenyl)-1H-2-(2-pyridyl)imidazole
  参考文献：
  名称：

  Microwave Enabled Umpulong Mechanism Based Rapid and Efficient Four- and Six-Component Domino Formations of 2-(2′-Azaaryl)imidazoles and anti-1,2-Diarylethylbenzamides

  摘要：

  Concise and efficient six-component and four-component domino approaches to anti-1,2-diarylethylbenzamides and highly Substituted 2-(2'-azaaryl)imidazoles have been developed under solvent-free and microwave-irradiation conditions. The reactions showed a broad scope of substrates in which a wide range of common commercial aromatic aldehydes and heteroaryl nitriles can be used. The syntheses were Finished within short periods (15-34 min) with good to excellent chemical yields and stereoselectivity that avoided tedious workup isolations. New mechanisms involving an umpolung have been proposed for these two reaction processes.

  DOI：

  10.1021/jo902204s