2,2,5-Trimethyl-tetrahydro-furan | 82004-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2,2,5-Trimethyl-tetrahydro-furan
• 英文别名: 2,2,5-trimethyloxolane
• CAS: 82004-72-6
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: YBCWTTVQTAFTNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2,5-Trimethyl-tetrahydro-furan 、 三甲基苯基硒硅烷 在 zinc(II) iodide 作用下， 以 二氯甲烷 为溶剂， 反应 50.0h， 以74%的产率得到trimethyl-(5-methyl-5-phenylselanylhexan-2-yl)oxysilane
  参考文献：
  名称：

  Ring Opening of Tetrahydrofurans with Phenyl Trimethylsilyl Selenide Catalyzed by Moist Zinc Iodide

  摘要：

  苯基三甲基甲硅烷基硒化物（1）与四氢呋喃2在二氯甲烷中，在催化量的碘化锌存在下反应，以良好产率得到开环的δ-苯基硒醇硅醚3。研究发现，经过水饱和己烷处理制备的含水碘化锌比完全干燥的碘化锌催化反应更有效。

  DOI：

  10.1055/s-1988-27505
• 作为产物：
  描述：

  2-甲基-2-己醇 在 calcium hypochlorite 、 碳酸氢钠 、 iron(II) sulfate 、 溶剂黄146 作用下， 以 四氯化碳 、 水 为溶剂， 反应 7.0h， 生成 2,2,5-Trimethyl-tetrahydro-furan
  参考文献：
  名称：

  亚铁离子诱导的次氯酸烷基酯的分解

  摘要：

  亚铁和其他单电子可氧化金属离子引起的伯，仲和叔烷基次氯酸盐的分解导致δ-氯醇的产率为34-76％。在叔烷基次氯酸盐的分解中，β碎片与分子内δ-氯化竞争。含五元或六元环的叔环烷基次氯酸盐经过β裂解得到相应的ω-氯酮，而亚铁离子分解后的1-甲基环庚基和1-甲基环辛基次氯酸盐通过δ-碳原子的环过官能化和β裂解而进行。作为竞争反应。

  DOI：

  10.1016/0040-4020(81)85021-1

文献信息

• HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
  申请人：AMGEN INC.

  公开号：US20170320860A1

  公开（公告）日：2017-11-09

  Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

  公式I和公式II的化合物，其药用盐，上述任何一个的立体异构体，或它们的混合物是APJ受体的激动剂，可能用于治疗心血管和其他疾病。公式I和公式II的化合物具有以下结构： 其中变量的定义在此提供。
• [EN] SERINE/THREONINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE SÉRINE/THRÉONINE KINASES
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2015103137A1

  公开（公告）日：2015-07-09

  Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

  提供具有公式I的化合物或其立体异构体、互变异构体或药用可接受盐，这些化合物用于治疗疾病。公开了使用公式I的化合物或其立体异构体、互变异构体或药用可接受盐，用于体外、原位和体内诊断、预防或治疗此类疾病或相关病理状况的方法。
• [EN] PYRIDINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS I<br/>[FR] COMPOSÉS DE PYRIDINE POUR LA LUTTE CONTRE DES ANIMAUX INVERTÉBRÉS I
  申请人：BASF SE

  公开号：WO2012034961A1

  公开（公告）日：2012-03-22

  The present invention relates to novel pyridine compounds of the formulae (I) and (II), to their salts, to their tautomers, to their N-oxides, and to the salts of these N-oxides or tautomers. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests. The invention also relates to a method for controlling invertebrate pests by using these compounds. The invention further relates to plant propagation material and to agricultural compositions comprising said compounds.

  本发明涉及公式（I）和（II）的新型吡啶化合物，以及它们的盐，互变异构体，N-氧化物以及这些N-氧化物或互变异构体的盐。这些化合物可用于 bekämpfung或控制无脊椎动物害虫，特别是节肢动物害虫。本发明还涉及使用这些化合物控制无脊椎动物害虫的方法。本发明还涉及植物繁殖材料和包含所述化合物的农业组合物。
• [EN] PYRAZOLE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS<br/>[FR] COMPOSÉS DE PYRAZOLE POUR LA LUTTE CONTRE DES PARASITES INVERTÉBRÉS
  申请人：BASF SE

  公开号：WO2010034737A1

  公开（公告）日：2010-04-01

  The present invention relates to pyrazole compounds of formulae I or Il and the salts and N-oxides thereof, formulae (I), (II), wherein A is a pyrazole radical of formulae A1, A2 or A3, wherein formulae (A1), (A2), (A3), # denotes the binding site; R41, R42, R43, R51 are H, halogen, CN, NO2, C1-C10-alkyl and the like; R52, R53 are H, halogen, CN, NO2, C1-C10-alkyl, and the like; R61, R62, R63 are H, CN, NO2, C1-C10-alkyl, and the like; T is C(Rt) or N; U is C(Ru) or N; V is C(Rv) or N; W is C(Rw) or N; with the proviso that at least one of the groups T, U, V and W is N; Rt, Ru, Rv, Rw are H, halogen, C1-C4-alkyl and the like; X1 is S, O or NR1a, wherein R1a is selected H, C1-C10-alkyl and the like; X2 is OR2a, NR2bR2c, S(O)mR2d, wherein m is 0, 1 or 2, R2a is C1-C4-alkyl, C1-C4-haloalkyl and the like, R2b, R2c are H, C1-C4-alkyl, C1-C4-haloalkyl and the like, or R2b and R2c together with the nitrogen atom to which they are bound form a heterocycle, and R2d is C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl and the like; and R1 is H, CN, C1-C10-alkyl and the like. The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.

  本发明涉及式I或II的吡唑化合物及其盐和N-氧化物，其中A是式A1、A2或A3的吡唑基团，式（A1）、（A2）、（A3）中#表示结合位点；R41、R42、R43、R51为H、卤素、CN、NO2、C1-C10烷基等；R52、R53为H、卤素、CN、NO2、C1-C10烷基等；R61、R62、R63为H、CN、NO2、C1-C10烷基等；T为C（Rt）或N；U为C（Ru）或N；V为C（Rv）或N；W为C（Rw）或N；但至少有一个T、U、V和W中的基团为N；Rt、Ru、Rv、Rw为H、卤素、C1-C4烷基等；X1为S、O或NR1a，其中R1a选择H、C1-C10烷基等；X2为OR2a、NR2bR2c、S（O）mR2d，其中m为0、1或2，R2a为C1-C4烷基、C1-C4卤代烷基等，R2b、R2c为H、C1-C4烷基、C1-C4卤代烷基等，或R2b和R2c与它们结合的氮原子形成杂环，R2d为C1-C4烷基、C1-C4卤代烷基、C3-C6环烷基等；R1为H、CN、C1-C10烷基等。本发明还涉及一种控制无脊椎动物害虫的方法，一种保护植物繁殖材料和/或从中生长的植物的方法，包括至少一种本发明化合物的植物繁殖材料，一种治疗或保护动物免受寄生虫感染的方法，以及含有至少一种本发明化合物的农业组合物。
• Pyrazole Compounds for Controlling Invertebrate Pests
  申请人：Gross Steffen

  公开号：US20110269770A1

  公开（公告）日：2011-11-03

  The present invention relates to pyrazole compounds of formulae I or II and the salts and N-oxides thereof, wherein A is a pyrazole radical of formulae A1, A2 or A3, wherein # denotes the binding site; R 41 , R 42 , R 43 , R 51 are H, halogen, CN, NO 2 , C 1 -C 10 -alkyl and the like; R 52 , R 53 are H, halogen, CN, NO 2 , C 1 -C 10 -alkyl, and the like; R 61 , R 62 , R 63 are H, CN, NO 2 , C 1 -C 10 -alkyl, and the like; T is C(R t ) or N; U is C(R u ) or N; V is C(R v ) or N; W is C(R w ) or N; with the proviso that at least one of the groups T, U, V and W is N; R t , R u , R v , R w are H, halogen, C 1 -C 4 -alkyl and the like; X 1 is S, O or NR 1a , wherein R 1a is selected H, C 1 -C 10 -alkyl and the like; X 2 is OR 2a , NR 2b R 2c , S(O) m R 2d , wherein m is 0, 1 or 2, R 2a is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and the like, R 2b , R 2c are H, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and the like, or R 2b and R 2c together with the nitrogen atom to which they are bound form a heterocycle, and R 2d is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl and the like; and R 1 is H, CN, C 1 -C 10 -alkyl and the like. The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.

  本发明涉及式I或II的吡唑化合物及其盐和N-氧化物，其中A是式A1、A2或A3的吡唑基团，在其中#表示结合位点；R41、R42、R43、R51为H、卤素、CN、NO2、C1-C10烷基等；R52、R53为H、卤素、CN、NO2、C1-C10烷基等；R61、R62、R63为H、CN、NO2、C1-C10烷基等；T为C（Rt）或N；U为C（Ru）或N；V为C（Rv）或N；W为C（Rw）或N；但其中至少有一个基团T、U、V和W是N；Rt、Ru、Rv、Rw为H、卤素、C1-C4烷基等；X1为S、O或NR1a，其中R1a选择为H、C1-C10烷基等；X2为OR2a、NR2bR2c、S（O）mR2d，其中m为0、1或2，R2a为C1-C4烷基、C1-C4卤代烷基等，R2b、R2c为H、C1-C4烷基、C1-C4卤代烷基等，或者R2b和R2c与它们所结合的氮原子形成杂环，R2d为C1-C4烷基、C1-C4卤代烷基、C3-C6环烷基等；R1为H、CN、C1-C10烷基等。本发明进一步涉及一种控制无脊椎动物害虫的方法，一种保护植物繁殖材料和/或生长的植物的方法，包括至少一种本发明化合物的植物繁殖材料，一种治疗或保护动物免受寄生虫感染或感染的方法，以及含有至少一种本发明化合物的农业组合物。