(2,3,11,12-tetramethoxyl)-5,6,7,9-tetrahydroindolo[2,3-e][3]benzazocin-8-one | 1415026-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (2,3,11,12-tetramethoxyl)-5,6,7,9-tetrahydroindolo[2,3-e][3]benzazocin-8-one
• 英文别名: 4,5,16,17-Tetramethoxy-10,13-diazatetracyclo[10.7.0.02,7.014,19]nonadeca-1(12),2,4,6,14,16,18-heptaen-11-one；4,5,16,17-tetramethoxy-10,13-diazatetracyclo[10.7.0.02,7.014,19]nonadeca-1(12),2,4,6,14,16,18-heptaen-11-one
• CAS: 1415026-96-8
• 化学式: C₂₁H₂₂N₂O₅
• 分子量: 382.416
• InChiKey: NNGMXFDPHVZDBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  藜芦酸 在 palladium(II) trifluoroacetate 、 氧气 、 copper diacetate 作用下， 以 二甲基亚砜 、 乙腈 为溶剂， 反应 22.08h， 生成 (2,3,11,12-tetramethoxyl)-5,6,7,9-tetrahydroindolo[2,3-e][3]benzazocin-8-one
  参考文献：
  名称：

  Palladium-catalyzed intramolecular C–H amidation: synthesis and biological activities of indolobenzazocin-8-ones

  摘要：

  The synthesis of multi ring-fused indolobenzazocinone derivatives, an antimitotic agent, has been carried out using palladium-catalyzed C-H activation/intramolecular amidation of benzo[d]azocinones, which were synthesized by the ring annulations of dihydroisoquinolines and azlactone in refluxing acetonitrile. The target compounds, indolobenzazocin-8-one derivatives, were evaluated for their cytotoxicity against the cancer cell lines HUCCA-1, A549, HepG2, and MOLT-3. The results showed that an unsubstituted indolobenzazocin-8-one le exhibited very good activities in the nanomolar IC50 value range (HepG2 and MOLT-3). Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.011

文献信息

• Palladium-catalyzed intramolecular C–H amidation: synthesis and biological activities of indolobenzazocin-8-ones
  作者：Sasiwadee Boonya-udtayan、Meredith Eno、Somsak Ruchirawat、Chulabhorn Mahidol、Nopporn Thasana

  DOI：10.1016/j.tet.2012.10.011

  日期：2012.12

  The synthesis of multi ring-fused indolobenzazocinone derivatives, an antimitotic agent, has been carried out using palladium-catalyzed C-H activation/intramolecular amidation of benzo[d]azocinones, which were synthesized by the ring annulations of dihydroisoquinolines and azlactone in refluxing acetonitrile. The target compounds, indolobenzazocin-8-one derivatives, were evaluated for their cytotoxicity against the cancer cell lines HUCCA-1, A549, HepG2, and MOLT-3. The results showed that an unsubstituted indolobenzazocin-8-one le exhibited very good activities in the nanomolar IC50 value range (HepG2 and MOLT-3). Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.