2-pentyl 2-methylpropanoate | 54340-93-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-pentyl 2-methylpropanoate
• 英文别名: sec-amyl isobutyrate；Propanoic acid, 2-methyl-, 1-methylbutyl ester；pentan-2-yl 2-methylpropanoate
• CAS: 54340-93-1
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: DUNWRGFRZIHKPT-UHFFFAOYSA-N

物化性质

• 沸点：
  165.2±8.0 °C(Predicted)
• 密度：
  0.872±0.06 g/cm3(Predicted)
• LogP：
  2.997 (est)
• 保留指数：
  974.1;1028

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基丁醇 、 异丁酸 在 Rhizomucor miehei lipase 作用下， 以 正庚烷 为溶剂， 反应 24.0h， 以97.7%的产率得到2-pentyl 2-methylpropanoate
  参考文献：
  名称：

  Divakar, Soundar, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 9, p. 1919 - 1922

  摘要：

  DOI：

文献信息

• PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES
  申请人：Blumberg Laura Cook

  公开号：US20110319422A1

  公开（公告）日：2011-12-29

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  该发明提供了一种持续释放内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药的方法，通过向患者施用该发明的一种前药化合物的有效量，在向患者施用后，从前药中释放母药是持续释放的。适用于该发明方法的前药化合物是母药的不稳定结合物，通过羰基连接的前药基团进行衍生化。该发明的前药化合物可用于治疗任何需要内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药作为治疗的情况。
• [EN] PROCESS FOR THE PREPARATION OF ACYLATED SECONDARY ALCOHOL ALKOXYLATES AND SECONDARY ALCOHOL ALKOXYLATES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ALCOXYLATES D'ALCOOLS SECONDAIRES ACYLÉS ET ALCOXYLATES D'ALCOOLS SECONDAIRES
  申请人：SHELL INT RESEARCH

  公开号：WO2010049465A1

  公开（公告）日：2010-05-06

  A process for the preparation of acylated secondary alcohol alkoxylates, said process comprising : (i) reaction of one or more internal olefins with one or more carboxylic acids in the presence of a catalyst composition in order to form one or more carboxylic acid esters; (ii) reaction of one or more carboxylic acid esters from step (i) with one or more alkylene oxide reactants, in the presence of a catalytically effective amount of a catalyst composition comprising: (a) one or more alkaline earth metal salts of carboxylic and/or hydroxycarboxylic acids and/or hydrates of the former; (b) an oxy-acid selected from sulphuric acid and ortho-phosphoric acid; (c) an alcohol and/or an ester; and/or products of the reciprocal reactions of (a), (b) and/or (c) in order to form one or more acylated secondary alcohol alkoxylates; and optionally (iii) hydrolysis or transesterification of one or more acylated secondary alcohol alkoxylates from step (ii) in order to form one or more secondary alcohol alkoxylates; and a process for making secondary alcohol alkoxy sulphates comprising the steps of: preparing secondary alcohol alkoxylates by the afore-mentioned process; and sulphating the secondary alcohol alkoxylates.

  一种制备酰化二次醇烷氧基化物的方法，该方法包括：（i）在催化剂组成物的存在下，将一种或多种内部烯烃与一种或多种羧酸反应，以形成一种或多种羧酸酯；（ii）在催化剂组成物的存在下，将步骤（i）中的一种或多种羧酸酯与一种或多种烷基氧化物反应，其中催化剂组成物包括：（a）一种或多种碱土金属羧酸和/或羟基羧酸盐和/或其水合物；（b）从硫酸和正磷酸中选择的氧酸；（c）一种醇和/或一种酯和/或（a），（b）和/或（c）的互反作用产物，以形成一种或多种酰化二次醇烷氧基化物；可选地（iii）水解或酯交换步骤，以形成一种或多种二次醇烷氧基化物。制备二次醇烷氧基硫酸盐的方法包括以下步骤：通过上述方法制备二次醇烷氧基化物；并对二次醇烷氧基化物进行硫酸化。
• Prodrugs of NH-Acidic Compounds: Ester, Carbonate, Carbamate and Phosphonate Derivatives
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20150320875A1

  公开（公告）日：2015-11-12

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  本发明提供了一种持续释放内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或尿素含量的母药的方法，通过向患者施用本发明的前药化合物的有效量，在患者体内释放母药的速率是持续释放的。适用于本发明方法的前药化合物是通过羰基偶联的前药基团衍生的母药的不稳定结合物。本发明的前药化合物可用于治疗任何需要内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或尿素含量的母药治疗的疾病。
• Erasable image forming material
  申请人：KABUSHIKI KAISHA TOSHIBA

  公开号：EP0980028A1

  公开（公告）日：2000-02-16

  An erasable image forming material includes a color former, a developer, a binder resin, and a polymer decolorizer having an electron donating group capable of physically or chemically adsorbing the developer. This polymer decolorizer is, e.g., a polymer compound having a sugar skeleton, representatively starch. This image forming material can form sharp images and erase images by heat or a solvent to achieve a good erased state.

  一种可擦除图像形成材料包括显色剂、粘合剂树脂和聚合物脱色剂，聚合物脱色剂具有电子捐赠基团，能以物理或化学方式吸附显色剂。聚合物脱色剂可以是具有糖骨架的聚合物化合物，例如淀粉。这种图像形成材料可以形成清晰的图像，并通过加热或溶剂擦除图像，以达到良好的擦除状态。
• Decolorable image forming material and decoloring method of the same
  申请人：Kabushiki Kaisha Toshiba

  公开号：EP1041447A1

  公开（公告）日：2000-10-04

  A decolorable image forming material containing a color former, a developer and a binder resin, in which the binder resin has a property that it is compatible with the color former when the material is in contact with a solvent and that it keeps the compatible state when the solvent is removed, or has a property that it shifts an equilibrium between the color former and the developer to a non-developed side when the temperature of the material is raised and that it keeps the state shifted to the non-developed side when the temperature of the material is lowered.

  一种含有显色剂、显影剂和粘合剂树脂的可脱色图像形成材料，其中粘合剂树脂具有以下特性：当材料与溶剂接触时，粘合剂树脂与显色剂相容；当溶剂移除时，粘合剂树脂保持相容状态；或者具有以下特性：当材料温度升高时，粘合剂树脂将显色剂与显影剂之间的平衡状态转移到非显影侧；当材料温度降低时，粘合剂树脂保持转移到非显影侧的状态。