2-methoxy-3-phenylpyrazine | 99984-63-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-methoxy-3-phenylpyrazine
• 英文别名: 2-Phenyl-3-methoxypyrazine
• CAS: 99984-63-1
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.213
• InChiKey: TXJSCDNLDZPGIW-UHFFFAOYSA-N

物化性质

• 沸点：
  143-145 °C(Press: 14 Torr)
• 密度：
  1.127±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-3-phenylpyrazine 在 盐酸 、 双氧水 、 溶剂黄146 、 三氯氧磷 作用下， 生成 2,5-二甲氧基-3-苯基-吡嗪
  参考文献：
  名称：

  Displacements and Nuclear Substitutions on Hydroxypyrazines

  摘要：

  DOI：

  10.1021/ja01597a057
• 作为产物：
  描述：

  氯化重氮苯 在 甲醇 、 sodium hydroxide 、 三氯氧磷 、 正丁醇 作用下， 生成 2-methoxy-3-phenylpyrazine
  参考文献：
  名称：

  Displacements and Nuclear Substitutions on Hydroxypyrazines

  摘要：

  DOI：

  10.1021/ja01597a057

文献信息

• Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex
  申请人：Inoue Hideko

  公开号：US20080312437A1

  公开（公告）日：2008-12-18

  According to the present invention, a wider variation of organometallic complexes that can emit phosphorescence can be provided by applying, as a ligand, an organic compound from which a variety of derivatives can be easily synthesized. In particular, an organometallic complex having a sharp emission spectrum is provided. Further, an organometallic complex having high emission efficiency is provided. An organometallic complex represented by the general formula (G1) is provided. In the formula, Ar represents an aryl group, R represents an alkoxy group having 1 to 4 carbon atoms, and R 1 and R 2 individually represent either hydrogen or an alkyl group having 1 to 4 carbon atoms.

  根据本发明，通过应用一种作为配体的有机化合物，可以提供更广泛的能够发射磷光的有机金属配合物变体，从而可以轻松合成各种衍生物。特别地，提供了具有尖锐发射光谱的有机金属配合物。此外，提供了具有高发射效率的有机金属配合物。提供了由通式（G1）表示的有机金属配合物。在该式中，Ar代表芳基，R代表具有1至4个碳原子的烷氧基，R1和R2分别表示氢或具有1至4个碳原子的烷基。
• Base-Mediated Intermolecular sp² C−H Bond Arylation via Benzyne Intermediates
  作者：Thanh Truong、Olafs Daugulis

  DOI：10.1021/ja200184b

  日期：2011.3.30

  A transition-metal-free method for arylation of heterocycle and arene carbon-hydrogen bonds by aryl chlorides and fluorides has been developed. The reactions proceed via aryne intermediates and are highly regioselective with respect to the C-H bond coupling component.

  开发了一种无过渡金属的方法，用于通过芳基氯化物和氟化物对杂环和芳烃碳氢键进行芳基化。反应通过芳炔中间体进行，并且对于 CH 键偶联组分具有高度区域选择性。
• Palladium−Ruthenium Catalyst Complementarity Strengthens <i>Ortho</i> ‐Directed C−H Bond Arylation of 2‐Arylpyrazines
  作者：Amal Benzai、Fazia Derridj、Henri Doucet、Jean‐François Soulé

  DOI：10.1002/cctc.202001338

  日期：2021.1.12

  We report the Pd‐ or Ru‐catalyzed C−H bond arylation at the ortho‐position of the aryl unit of 2‐arylpyrazines. The reaction proceeds with complete regioselectivity using phosphine‐free Pd(OAc)2 or [RuCl2(p‐cymene]2 as the catalysts and potassium acetate as an inexpensive base. In all cases, the mono‐arylation of 2‐arylpyrazines was obtained even with 2,3‐diphenylpyrazine. Moreover, the reaction is

  我们报告了在2-芳基吡嗪的芳基单元的邻位上Pd或Ru催化的CH键芳基化。使用无膦的Pd（OAc）2或[RuCl 2（p- cymene）2作为催化剂，乙酸钾作为廉价的碱，可实现完全的区域选择性，在所有情况下均获得了2-芳基吡嗪的单芳基化反应即使使用2,3-二苯基吡嗪，该反应对吡嗪取代也不敏感，通过选择合适的催化体系，已经成功地制得了各种富电子和贫（杂）芳基溴化物，包括溴吡啶衍生物。受雇。
• Organometallic Complex, and Light-Emitting Element, Light-Emitting Device and Electronic Device Using the Organometallic Complex
  申请人：Semiconductor Energy Laboratory Co., Ltd.

  公开号：US20130079516A1

  公开（公告）日：2013-03-28

  According to the present invention, a wider variation of organometallic complexes that can emit phosphorescence can be provided by applying, as a ligand, an organic compound from which a variety of derivatives can be easily synthesized. In particular, an organometallic complex having a sharp emission spectrum is provided. Further, an organometallic complex having high emission efficiency is provided. An organometallic complex represented by the general formula (G1) is provided. In the formula, Ar represents an aryl group, R represents an alkoxy group having 1 to 4 carbon atoms, and R 1 and R 2 individually represent either hydrogen or an alkyl group having 1 to 4 carbon atoms.

  根据本发明，通过将一种有机化合物作为配体应用，可以提供更广泛的能够发射磷光的有机金属配合物变体，从该有机化合物可以轻松合成多种衍生物。特别地，提供了一种具有尖锐发射光谱的有机金属配合物。此外，还提供了一种具有高发射效率的有机金属配合物。提供了一种由通式（G1）表示的有机金属配合物。在该式中，Ar代表芳基基团，R代表具有1到4个碳原子的烷氧基团，R1和R2分别表示氢或具有1到4个碳原子的烷基基团。
• Organometallic complex, and light-emitting element, light-emitting device and electronic device using the organometallic complex
  申请人：Semiconductor Energy Laboratory Co., Ltd.

  公开号：US08541574B2

  公开（公告）日：2013-09-24

  According to the present invention, a wider variation of organometallic complexes that can emit phosphorescence can be provided by applying, as a ligand, an organic compound from which a variety of derivatives can be easily synthesized. In particular, an organometallic complex having a sharp emission spectrum is provided. Further, an organometallic complex having high emission efficiency is provided. An organometallic complex represented by the general formula (G1) is provided. In the formula, Ar represents an aryl group, R represents an alkoxy group having 1 to 4 carbon atoms, and R1 and R2 individually represent either hydrogen or an alkyl group having 1 to 4 carbon atoms.

  根据本发明，通过应用一种有机化合物作为配体，可以提供更广泛的能够发射荧光的有机金属配合物的变化，从而可以轻松地合成多种衍生物。特别地，提供了具有尖锐发射光谱的有机金属配合物。此外，还提供了具有高发射效率的有机金属配合物。提供了一种由通式（G1）表示的有机金属配合物。在该式中，Ar表示芳基，R表示具有1至4个碳原子的烷氧基，R1和R2分别表示氢或具有1至4个碳原子的烷基。