2-sodio-1,3-dimethoxybenzene | 91862-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-sodio-1,3-dimethoxybenzene
• CAS: 91862-17-8
• 化学式: C₈H₉NaO₂
• 分子量: 160.148
• InChiKey: HFISXRKAWJEFON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.12
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-sodio-1,3-dimethoxybenzene 生成 2,6-二甲氧基苯甲酸
  参考文献：
  名称：

  SAVIN, V. P.;SEMENOVA, G. E.;BEK, N. O., SOZDANIE PERSPEKT. PESTITSIDOV I SYRYA DLYA IX PR-BA, UFA,(1989) S. 17-18

  摘要：

  DOI：
• 作为产物：
  描述：

  间苯二甲醚 在 1-氯辛烷 、 sodium 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 3.0h， 生成 2-sodio-1,3-dimethoxybenzene
  参考文献：
  名称：

  An efficient synthesis of biaryls via noncatalysed anionic coupling of an arylsodium with haloarenes

  摘要：

  Noncatalysed anionic coupling of an arylsodium with haloarenes readily gives access to valuable biaryl structures. Compared to aryllithiums, the reaction with arylsodiums is faster and can be performed at lower temperature. The coupling with substituted haloarenes proceeds often with a high degree of regioselectivity. Since only cheap and readily available substrates are involved, this coupling is particularly suited for the large scale synthesis of basic biaryl building blocks. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2004.10.123

文献信息

• SAVIN, V. P.;SEMENOVA, G. E.;BEK, N. O., SOZDANIE PERSPEKT. PESTITSIDOV I SYRYA DLYA IX PR-BA, UFA,(1989) S. 17-18
  作者：SAVIN, V. P.、SEMENOVA, G. E.、BEK, N. O.

  DOI：——

  日期：——
• JPS62234089A
  申请人：——

  公开号：JPS62234089A

  公开（公告）日：1987-10-14
• An efficient synthesis of biaryls via noncatalysed anionic coupling of an arylsodium with haloarenes
  作者：Jean-Michel Becht、Arnaud Gissot、Alain Wagner、Charles Mioskowski

  DOI：10.1016/j.tetlet.2004.10.123

  日期：2004.12

  Noncatalysed anionic coupling of an arylsodium with haloarenes readily gives access to valuable biaryl structures. Compared to aryllithiums, the reaction with arylsodiums is faster and can be performed at lower temperature. The coupling with substituted haloarenes proceeds often with a high degree of regioselectivity. Since only cheap and readily available substrates are involved, this coupling is particularly suited for the large scale synthesis of basic biaryl building blocks. (C) 2004 Published by Elsevier Ltd.