4-hydroxy-3-(pyridin-4-yl-pyrrolidin-1-yl-methyl)-chromen-2-one | 1380515-07-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-hydroxy-3-(pyridin-4-yl-pyrrolidin-1-yl-methyl)-chromen-2-one
• 英文别名: 4-Hydroxy-3-[pyridin-4-yl(pyrrolidin-1-yl)methyl]chromen-2-one；4-hydroxy-3-[pyridin-4-yl(pyrrolidin-1-yl)methyl]chromen-2-one
• CAS: 1380515-07-0
• 化学式: C₁₉H₁₈N₂O₃
• 分子量: 322.364
• InChiKey: OHOLSAFTFGDMQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 4-吡啶甲醛 、 4-羟基香豆素 在 zinc(II) oxide 作用下， 以 水 为溶剂， 反应 0.33h， 以87%的产率得到4-hydroxy-3-(pyridin-4-yl-pyrrolidin-1-yl-methyl)-chromen-2-one
  参考文献：
  名称：

  Nano crystalline ZnO: a competent and reusable catalyst for one pot synthesis of novel benzylamino coumarin derivatives in aqueous media

  摘要：

  A green, efficient and facile protocol was developed for the synthesis of a series of benzylamino coumarin derivatives by the reaction of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in aqueous media in the presence of nano crystalline ZnO at room temperature. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. The nano crystalline ZnO can be recycled five times with almost the same catalytic activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.033

文献信息

• Nano crystalline ZnO: a competent and reusable catalyst for one pot synthesis of novel benzylamino coumarin derivatives in aqueous media
  作者：Partha Pratim Ghosh、Asish R. Das

  DOI：10.1016/j.tetlet.2012.04.033

  日期：2012.6

  A green, efficient and facile protocol was developed for the synthesis of a series of benzylamino coumarin derivatives by the reaction of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in aqueous media in the presence of nano crystalline ZnO at room temperature. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. The nano crystalline ZnO can be recycled five times with almost the same catalytic activity. (C) 2012 Elsevier Ltd. All rights reserved.