2-(3-Chloropropylamino)acetic acid | 1071150-36-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(3-Chloropropylamino)acetic acid
• CAS: 1071150-36-1
• 化学式: C₅H₁₀ClNO₂
• mdl: MFCD19235832
• 分子量: 151.593
• InChiKey: CMQDQXJZJCAGLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-Chloropropylamino)acetic acid 在 碳酸氢钠 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成 N-tert-butoxycarbonyl-proline
  参考文献：
  名称：

  Intramolecular alkylation of carboxylic acids: application to the synthesis of boc-protected cyclic amino acids

  摘要：

  A new synthesis of Boc-protected cyclic amino acids is described as an application of an unreported method of lithium diisopropylamide-induced cyclisation of omega-chloro carboxylic acids containing a protected amine function in the chain.

  DOI：

  10.1039/c39940000879
• 作为产物：
  描述：

  3-氯丙胺盐酸盐 、 乙醛酸 在 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 2-(3-Chloropropylamino)acetic acid
  参考文献：
  名称：

  Intramolecular alkylation of carboxylic acids: application to the synthesis of boc-protected cyclic amino acids

  摘要：

  A new synthesis of Boc-protected cyclic amino acids is described as an application of an unreported method of lithium diisopropylamide-induced cyclisation of omega-chloro carboxylic acids containing a protected amine function in the chain.

  DOI：

  10.1039/c39940000879

文献信息

• MODIFIED PEPTOIDS
  申请人：Technion Research & Development Foundation Limited

  公开号：US20200055897A1

  公开（公告）日：2020-02-20

  Peptoids are described herein, as well as compositions comprising an aqueous liquid and a peptoid soluble in the aqueous liquid. The peptoids comprise a plurality of N-substituted glycine residues and/or N-substituted β-alanine residues, and at least one heteroalicyclic residue having a general formula: wherein W, X, Y 1 , Y 2 , Z 1 and Z 2 are as defined herein.
• Intramolecular alkylation of carboxylic acids: application to the synthesis of boc-protected cyclic amino acids
  作者：A. De Nicola、C. Einhorn、J. Einhorn、J. L. Luche

  DOI：10.1039/c39940000879

  日期：——

  A new synthesis of Boc-protected cyclic amino acids is described as an application of an unreported method of lithium diisopropylamide-induced cyclisation of omega-chloro carboxylic acids containing a protected amine function in the chain.