4-(3,5-di(ethoxycarbonyl)-1,4-dihydro-1-(4-methoxyphenyl)pyridin-4-yl)benzoic acid | 1326224-21-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(3,5-di(ethoxycarbonyl)-1,4-dihydro-1-(4-methoxyphenyl)pyridin-4-yl)benzoic acid
• 英文别名: 4-[3,5-bis(ethoxycarbonyl)-1-(4-methoxyphenyl)-4H-pyridin-4-yl]benzoic acid
• CAS: 1326224-21-8
• 化学式: C₂₅H₂₅NO₇
• 分子量: 451.476
• InChiKey: UCVWNVQOHMRESR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3,3-二乙氧基丙酸乙酯 、 甲氧苯胺 、 对醛基苯甲酸 在 ytterbium(III) triflate 作用下， 以 1,4-二氧六环 为溶剂， 以82%的产率得到4-(3,5-di(ethoxycarbonyl)-1,4-dihydro-1-(4-methoxyphenyl)pyridin-4-yl)benzoic acid
  参考文献：
  名称：

  Ytterbium-catalyzed synthesis of dihydropyridines

  摘要：

  The reaction of anilines, benzaldehydes. and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)(3) proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.070

文献信息

• Ytterbium-catalyzed synthesis of dihydropyridines
  作者：Shunsuke Sueki、Ryo Takei、Junya Abe、Isao Shimizu

  DOI：10.1016/j.tetlet.2011.06.070

  日期：2011.8

  The reaction of anilines, benzaldehydes. and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)(3) proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields. (C) 2011 Elsevier Ltd. All rights reserved.