6-(benzylthio)pyridin-2-amine | 143914-52-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-(benzylthio)pyridin-2-amine
• 英文别名: 6-Benzylsulfanylpyridin-2-amine
• CAS: 143914-52-7
• 化学式: C₁₂H₁₂N₂S
• 分子量: 216.307
• InChiKey: OKJRIEHGRKJILB-UHFFFAOYSA-N

物化性质

• 沸点：
  396.3±37.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(benzylthio)pyridin-2-amine 在 4-二甲氨基吡啶 、 ammonium hydroxide 、 氯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 氯仿 、 水 、 乙腈 为溶剂， 反应 47.5h， 生成 tert-butyl (6-(N-(1-(2-bromo-5-methylphenoxy)cyclopropane-1-carbonyl)sulfamoyl)pyridin-2-yl)carbamate
  参考文献：
  名称：

  WO2020128768A5

  摘要：

  公开号：

  WO2020128768A5
• 作为产物：
  描述：

  2-benzylsulphenyl-6-bromopyridine 在 氯化亚铜 ammonium hydroxide 作用下， 生成 6-(benzylthio)pyridin-2-amine
  参考文献：
  名称：

  Substituted pyridinesulfonamide compound or its salt, process for

  摘要：

  该化合物或其盐的一种替代吡啶磺酰胺化合物，其由以下一般式(I)所代表：##STR1## 其中A为CH或N；当A为CH时，R.sub.1和R.sub.2可以是未取代或取代的烷基、未取代或取代的烯基、未取代或取代的环烷基和未取代或取代的苯基中各自独立选自的成员；当A为N时，R.sub.1是未取代或取代的烷基，R.sub.2是未取代或取代的烷基，或未取代或取代的烷氧基；X和Y分别是选自烷基和烷氧基的成员中各自独立选自的成员。该化合物可用作除草剂的有效成分，即使用量很少也可显示广泛的除草谱。

  公开号：

  US05348933A1

文献信息

• [EN] N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE<br/>[FR] DÉRIVÉS DE N- (PYRIDIN-2-YL) PYRIDINE-SULFONAMIDE ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE MALADIE
  申请人：NOVARTIS AG

  公开号：WO2018042316A1

  公开（公告）日：2018-03-08

  The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

  该发明涉及具有以下式（I）的杂环化合物，其中所有变量均如规范中定义；能够调节CFTR活性。该发明还提供了一种制造该发明化合物的方法，以及其治疗用途。该发明还提供了制备这些化合物的方法，它们的医疗用途，特别是它们在囊性纤维化和相关疾病或疾病的治疗和管理中的用途。
• Substituted pyridinesulfonamide compound or its salt, process for preparing the same, and herbicide containing the same
  申请人：ISHIHARA SANGYO KAISHA, Ltd.

  公开号：EP0496608A1

  公开（公告）日：1992-07-29

  A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): wherein R₁ and R₂ may be either each independently a member selected from the group consisting of unsubstituted or substituted alkyl groups, unsubstituted or substituted alkenyl groups, unsubstituted or substituted cycloalkyl groups, and unsubstituted or substituted phenyl groups, or combined with each other to form a -(CH₂)n- group wherein n is an integer of 2 to 5; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.

  由以下通式 (I) 代表的取代的吡啶磺酰胺化合物或其盐： 其中，R₁ 和 R₂ 可以各自独立地为选自由未取代或取代的烷基、未取代或取代的烯基、未取代或取代的环烷基和未取代或取代的苯基组成的组中的成员，或相互结合形成-(CH₂)n-基团，其中 n 为 2 至 5 的整数；X 和 Y 可以各自独立地为选自由烷基和烷氧基组成的组中的成员。这种化合物可作为除草剂的有效成分，即使用量很少，也能显示出广泛的除草谱。
• N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease
  申请人：Novartis AG

  公开号：US11066369B2

  公开（公告）日：2021-07-20

  The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

  本发明涉及式 (I) 的杂环化合物 其中所有变量如说明书中所定义；能够调节 CFTR 的活性。本发明进一步提供了制造本发明化合物的方法及其治疗用途。本发明进一步提供了其制备方法、医疗用途，特别是用于治疗和管理包括囊性纤维化和相关疾病在内的疾病或紊乱。
• N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease
  申请人：Novartis AG

  公开号：US20180072673A1

  公开（公告）日：2018-03-15

  The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
• US5348933A
  申请人：——

  公开号：US5348933A

  公开（公告）日：1994-09-20