2-benzylsulphenyl-6-bromopyridine | 93681-52-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-benzylsulphenyl-6-bromopyridine
• 英文别名: 2-(benzylthio)-6-bromopyridine；2-benzylthio-6-bromopyridine；2-bromo-6-benzylthiopyridine；2-benzylsulfanyl-6-bromopyridine
• CAS: 93681-52-8
• 化学式: C₁₂H₁₀BrNS
• 分子量: 280.188
• InChiKey: HSTKPMACWCTQHY-UHFFFAOYSA-N

物化性质

• 沸点：
  382.8±37.0 °C(Predicted)
• 密度：
  1.49±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-benzylsulphenyl-6-bromopyridine 在 盐酸 、 sodium hypochlorite 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.5h， 生成 6-溴吡啶-2-磺酰胺
  参考文献：
  名称：

  [EN] BENZOTHIAZOLE COMPOUNDS
  [FR] COMPOSÉS DE BENZOTHIAZOLE

  摘要：

  本发明涉及模拟BH3-only蛋白活性并能够结合和中和促生存Bcl-2蛋白的苯并噻唑化合物。该发明还涉及利用这类化合物调节细胞死亡或细胞存活，在治疗和/或预防与细胞死亡或细胞存活失调相关的疾病或病况。

  公开号：

  WO2009039553A1
• 作为产物：
  描述：

  2,6-二溴吡啶 、 苄硫醇 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 水 、 甲苯 为溶剂， 反应 4.0h， 生成 2-benzylsulphenyl-6-bromopyridine
  参考文献：
  名称：

  [EN] BENZOTHIAZOLE COMPOUNDS
  [FR] COMPOSÉS DE BENZOTHIAZOLE

  摘要：

  本发明涉及模拟BH3-only蛋白活性并能够结合和中和促生存Bcl-2蛋白的苯并噻唑化合物。该发明还涉及利用这类化合物调节细胞死亡或细胞存活，在治疗和/或预防与细胞死亡或细胞存活失调相关的疾病或病况。

  公开号：

  WO2009039553A1

文献信息

• Hetaryl Bromides Bearing the SO₂ F Group - Versatile Substrates for Palladium-Catalyzed C-C Coupling Reactions
  作者：Artem Yu. Cherepakha、Kateryna O. Stepannikova、Bohdan V. Vashchenko、Marian V. Gorichko、Andrey A. Tolmachev、Oleksandr O. Grygorenko

  DOI：10.1002/ejoc.201801270

  日期：2018.12.19

  and six‐membered heteroaromatic sulfonyl fluorides bearing the Br atom at various positions of the heterocyclic ring were prepared. Chemoselective Suzuki, Stille, and Negishi sp2–sp2 or sp2–sp3 C–C cross‐coupling reactions proceed at the aryl bromide moiety with 69–98 % yields with expected tolerance of the SO2F group towards the coupling reaction conditions.

  制备了在杂环的各个位置带有Br原子的五元和六元杂芳族磺酰氟。化学选择性的Suzuki，Stille和Negishi sp 2 –sp 2或sp 2 –sp 3 C–C交叉偶联反应在芳基溴化物部分进行，产率为69–98％，SO 2 F基团对偶联反应的预期耐受性条件。
• Substituted pyridinesulfonamide compounds or their salts, process for preparing the same, and herbicides containing the same
  申请人：ISHIHARA SANGYO KAISHA, Ltd.

  公开号：EP0562731A1

  公开（公告）日：1993-09-29

  A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): wherein R₁ is an unsubstituted or substituted alkyl group; R₂ is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.

  公开了一种由以下通式（I）表示的取代吡啶磺酰胺化合物或其盐：其中R₁是未取代或取代的烷基基团；R₂是未取代或取代的烷基基团，或未取代或取代的烷氧基团；X和Y分别是从烷基基团和烷氧基团组成的群中选择的成员。该化合物可用作除草剂的有效成分，即使用量很少也能显示广泛的除草谱。
• Substituted pyridinesulfonamide compound or its salt, process for
  申请人：Ishihara Sangyo Kaisha, Ltd.

  公开号：US05348933A1

  公开（公告）日：1994-09-20

  A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): ##STR1## wherein A is CH or N; when A is CH, R.sub.1 and R.sub.2 may be either each independently a member selected from the group consisting of unsubstituted or substituted alkyl groups, unsubstituted or substituted alkenyl groups, unsubstituted or substituted cycloalkyl groups, and unsubstituted or substituted phenyl groups; when A is N, R.sub.1 is an unsubstituted or substituted alkyl group, R.sub.2 is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.

  该化合物或其盐的一种替代吡啶磺酰胺化合物，其由以下一般式(I)所代表：##STR1## 其中A为CH或N；当A为CH时，R.sub.1和R.sub.2可以是未取代或取代的烷基、未取代或取代的烯基、未取代或取代的环烷基和未取代或取代的苯基中各自独立选自的成员；当A为N时，R.sub.1是未取代或取代的烷基，R.sub.2是未取代或取代的烷基，或未取代或取代的烷氧基；X和Y分别是选自烷基和烷氧基的成员中各自独立选自的成员。该化合物可用作除草剂的有效成分，即使用量很少也可显示广泛的除草谱。
• Certain 2-alkanesulfonamido-pyridine derivatives
  申请人：Ishihara Sangyo Kaisha, Ltd.

  公开号：US05583231A1

  公开（公告）日：1996-12-10

  A substituted pyridinesulfonamide compound or its salt represented by the following general formula (I): ##STR1## wherein A is CH or N; when A is CH, R.sub.1 and R.sub.2 may be either each independently a member selected from the group consisting of unsubstituted or substituted alkyl groups, unsubstituted or substituted alkenyl groups, unsubstituted or substituted cycloalkyl groups, and unsubstituted or substituted phenyl groups; when A is N, R.sub.1 is an unsubstituted or substituted alkyl group, R.sub.2 is an unsubstituted or substituted alkyl group, or an unsubstituted or substituted alkoxy group; and X and Y are each independently a member selected from the group consisting of alkyl groups and alkoxy groups, is disclosed. This compound is useful as the effective ingredient of a herbicide showing a wide weed-control spectrum even if used in a small amount.

  以下是一种由以下通式（I）表示的取代的吡啶磺酰胺化合物或其盐：##STR1## 其中A为CH或N; 当A为CH时，R1和R2可以分别为未取代或取代的烷基，未取代或取代的烯基，未取代或取代的环烷基和未取代或取代的苯基中的任意一种; 当A为N时，R1为未取代或取代的烷基，R2为未取代或取代的烷基或未取代或取代的烷氧基; 而X和Y各自独立地为从烷基和烷氧基中选择的一种。该化合物可用作除草剂的有效成分，即使使用少量也能显示广泛的杂草控制谱。
• BENZOTHIAZOLE COMPOUNDS
  申请人：Watson Keith Geoffrey

  公开号：US20100197711A1

  公开（公告）日：2010-08-05

  The present invention relates to benzothiazole compounds that mimic the activity of BH3 only proteins and are capable of binding to and neutralizing pro survival Bcl 2 proteins. The invention also relates to the use of such compounds in the regulation of cell death or cell survival and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death or cell survival.

  本发明涉及苯并噻唑化合物，其模拟BH3仅蛋白的活性，并能够结合和中和促生存的Bcl-2蛋白。本发明还涉及使用这种化合物来调节细胞死亡或细胞存活以及治疗和/或预防与细胞死亡或细胞存活失调相关的疾病或病症。