10-amino-1-methoxyphenanthrene-9-carbonitrile | 1224954-05-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 10-amino-1-methoxyphenanthrene-9-carbonitrile
• 英文别名: 10-Amino-1-methoxyphenanthrene-9-carbonitrile
• CAS: 1224954-05-5
• 化学式: C₁₆H₁₂N₂O
• 分子量: 248.284
• InChiKey: XRXHSNSVERFXHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzonitrile 、 邻溴氰苄 在 四(三苯基膦)钯 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.67h， 生成 10-amino-1-methoxyphenanthrene-9-carbonitrile
  参考文献：
  名称：

  One-pot synthesis of novel poly-substituted phenanthrenes

  摘要：

  A one-pot synthesis of novel poly-substituted phenanthrenes is described in this article through a Suzuki-Miyaura cross-coupling followed by a Dieckmann-Thorpe ring closure under microwave irradiation. The selection of the appropriate starting materials allowed us to introduce diversity on various positions of the phenanthrene ring system. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.060

文献信息

• One-pot synthesis of novel poly-substituted phenanthrenes
  作者：Rodrigue Yougnia、Christophe Rochais、Jana Sopkovà-de Oliveira Santos、Patrick Dallemagne、Sylvain Rault

  DOI：10.1016/j.tet.2010.02.060

  日期：2010.4

  A one-pot synthesis of novel poly-substituted phenanthrenes is described in this article through a Suzuki-Miyaura cross-coupling followed by a Dieckmann-Thorpe ring closure under microwave irradiation. The selection of the appropriate starting materials allowed us to introduce diversity on various positions of the phenanthrene ring system. (C) 2010 Elsevier Ltd. All rights reserved.