2,4-dichloro-6-(2-ethoxyanilino)-s-triazine | 59565-46-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-dichloro-6-(2-ethoxyanilino)-s-triazine
• 英文别名: 4,6-dichloro-N-(2-ethoxyphenyl)-1,3,5-triazin-2-amine
• CAS: 59565-46-7
• 化学式: C₁₁H₁₀Cl₂N₄O
• 分子量: 285.133
• InChiKey: NSTMGPSNDKQBJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-dichloro-6-(2-ethoxyanilino)-s-triazine 以 1,4-二氧六环 为溶剂， 反应 4.5h， 生成 2-dimethylamino-4-(2-ethoxyanilino)-6-(isonicotinylhydrazino)-s-triazine
  参考文献：
  名称：

  Langalia; Thaker, Journal of the Indian Chemical Society, 1981, vol. 58, # 1, p. 89 - 90

  摘要：

  DOI：
• 作为产物：
  描述：

  三聚氯氰 、 氨基苯乙醚 以 乙腈 为溶剂， 反应 4.0h， 生成 2,4-dichloro-6-(2-ethoxyanilino)-s-triazine
  参考文献：
  名称：

  N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

  摘要：

  A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related Sugar hydrolases enzymes are described. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.08.050

文献信息

• LANGALIA N. A.; THAKER K. A., J. INDIAN CHEM. SOC., 1981, 58, NO 1, 89-90
  作者：LANGALIA N. A.、 THAKER K. A.

  DOI：——

  日期：——
• N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease
  作者：Wenwei Huang、Wei Zheng、Daniel J. Urban、James Inglese、Ellen Sidransky、Christopher P. Austin、Craig J. Thomas

  DOI：10.1016/j.bmcl.2007.08.050

  日期：2007.11

  A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related Sugar hydrolases enzymes are described. Published by Elsevier Ltd.
• Langalia; Thaker, Journal of the Indian Chemical Society, 1981, vol. 58, # 1, p. 89 - 90
  作者：Langalia、Thaker

  DOI：——

  日期：——