1-hexadecyl-2-methoxybenzene | 22165-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-hexadecyl-2-methoxybenzene
• CAS: 22165-09-9
• 化学式: C₂₃H₄₀O
• 分子量: 332.57
• InChiKey: SDWPUZUXLBCZPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-hexadecyl-2-methoxybenzene 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 2-十六烷基苯酚
  参考文献：
  名称：

  Phosphocholine derivatives having antihypertensive action

  摘要：

  磷酸胆碱衍生物和组合物被描述为在温血动物中作为降压剂和治疗高血压的有用药物。

  公开号：

  US04640913A1
• 作为产物：
  描述：

  碘十六烷 、 2-溴苯甲醚 在 dilithium tetrachlorocuprate 、 magnesium 作用下， 生成 1-hexadecyl-2-methoxybenzene
  参考文献：
  名称：

  Analogs of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain

  摘要：

  Analogues of platelet activating factor (PAF) in which the ether oxygen has been removed (6) and in which the alkoxy chain at C1 has been replaced with a o-, p-, or m-alkylphenoxy group (30, 31, and 35, respectively) have been prepared. Compound 6 shows reduced platelet aggregation and hypotensive activity in comparison with C16 and C18 PAF. The results obtained for compounds 30, 31, and 35 indicate that the hypotensive and platelet aggregating responses are sensitive to structural modification of the ether chain. The ortho analogue 30 shows no platelet aggregating activity and only a weak hypotensive response. The para analogue 31 exhibits a moderate decrease in activity in both assays. The meta analogue 35 is the most active of the three.

  DOI：

  10.1021/jm00375a016

文献信息

• Phosphocholine derivatives having antihypertensive action
  申请人：American Cyanamid Company

  公开号：US04640913A1

  公开（公告）日：1987-02-03

  Phosphocholine derivatives and compositions are described which are useful as hypotensive agents and in the treatment of hypertension in warm-blooded animals.

  磷酸胆碱衍生物和组合物被描述为在温血动物中作为降压剂和治疗高血压的有用药物。
• US4640913A
  申请人：——

  公开号：US4640913A

  公开（公告）日：1987-02-03
• Analogs of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain
  作者：A. Wissner、P. E. Sum、R. E. Schaub、C. A. Kohler、B. M. Goldstein

  DOI：10.1021/jm00375a016

  日期：1984.9

  Analogues of platelet activating factor (PAF) in which the ether oxygen has been removed (6) and in which the alkoxy chain at C1 has been replaced with a o-, p-, or m-alkylphenoxy group (30, 31, and 35, respectively) have been prepared. Compound 6 shows reduced platelet aggregation and hypotensive activity in comparison with C16 and C18 PAF. The results obtained for compounds 30, 31, and 35 indicate that the hypotensive and platelet aggregating responses are sensitive to structural modification of the ether chain. The ortho analogue 30 shows no platelet aggregating activity and only a weak hypotensive response. The para analogue 31 exhibits a moderate decrease in activity in both assays. The meta analogue 35 is the most active of the three.