2-(溴甲基)-3-甲基环氧乙烷 | 3055-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: 2-(溴甲基)-3-甲基环氧乙烷
• 英文名称: 2-(bromomethyl)-3-methyloxirane
• 英文别名: 2-Brommethyl-3-methyloxiran；1-bromo-2,3-epoxybutane；2-bromomethyl-3-methyl-oxirane；1-bromo-2,3-epoxy-butane；1-Brom-2,3-epoxy-butan；1-Brom-2.3-epoxy-butan
• CAS: 3055-09-2
• 化学式: C₄H₇BrO
• 分子量: 151.003
• InChiKey: PNKIAICRRFHSBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2910900090

反应信息

• 作为反应物：
  描述：

  2-(溴甲基)-3-甲基环氧乙烷 在 indium(III) chloride 、 sodium tetrahydroborate 作用下， 以 乙腈 为溶剂， 反应 6.5h， 以81%的产率得到3-丁烯-2-醇
  参考文献：
  名称：

  Selective reductive cleavage of 2,3-epoxybromides by the InCl3–NaBH4 reagent system

  摘要：

  A combination of sodium borohydride and a catalytic amount of indium(Ill) chloride in acetonitrile reduces 2,3-epoxy-bromides to the corresponding allylic alcohols in good yields involving reduction of the bromo moiety followed by selective C-O bond cleavage through a radical process. Several aromatic, cyclic and open-chain bromoepoxides successfully participated in this reaction. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.120
• 作为产物：
  描述：

  巴豆醇 在 三溴化磷 、 间氯过氧苯甲酸 作用下， 生成 2-(溴甲基)-3-甲基环氧乙烷
  参考文献：
  名称：

  Selective reductive cleavage of 2,3-epoxybromides by the InCl3–NaBH4 reagent system

  摘要：

  A combination of sodium borohydride and a catalytic amount of indium(Ill) chloride in acetonitrile reduces 2,3-epoxy-bromides to the corresponding allylic alcohols in good yields involving reduction of the bromo moiety followed by selective C-O bond cleavage through a radical process. Several aromatic, cyclic and open-chain bromoepoxides successfully participated in this reaction. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.120

文献信息

• Synthesis of 2,6-Disubstituted-1,3a,6a-Triazapentalenes and Their Fluorescence Properties
  作者：Akane Mera、Masami Ito、Atsushi Nakayama、Kosuke Namba

  DOI：10.1246/cl.170078

  日期：2017.4.5

  The substituent effect at the C6-position of 1,3a,6a-triazapentalenes was elucidated. Synthesis of C6-substituted-1,3a,6a-triazapentalene was established by an epoxide-opening reaction of the 1,2,3-triazoles followed by elimination of the resulting hydroxy group. The electron-donating substituent induced a longer-wavelength shift of the fluorescence maximum and change of the fluorescence quantum yield

  阐明了 1,3a,6a-三氮杂戊烯在 C6 位的取代作用。C6-取代的-1,3a,6a-三氮杂戊烯的合成是通过1,2,3-三唑的环氧化物开环反应然后消除所得羟基来建立的。给电子取代基引起荧光最大值的较长波长位移和荧光量子产率的变化，这取决于 C2 取代基。另一方面，吸电子基团淬灭了 1,3a,6a-三氮杂戊烯的荧光。
• Immunosuppressants
  申请人：Eli Lilly and Company

  公开号：US04000275A1

  公开（公告）日：1976-12-28

  Benzimidazo[2,1-b]quinazolin-12(6H)ones, immunosuppressives and agents for treatment of auto-immune diseases, are prepared via (1) reacting a 2-chlorobenzimidazole with an anthranilic acid or ester; (2) reacting a 2-aminobenzimidazole with an anthranilic acid or ester in the presence of trifluoroacetic acid or (3) reacting a 2-methylmercaptobenzimidazole with an anthraniloyl halide hydrohalide.

  苯并咪唑[2,1-b]喹唑啉-12(6H)酮，是一种免疫抑制剂和治疗自身免疫性疾病的药物，可通过以下方法制备：(1)将2-氯苯并咪唑与蒽酰氨或酯反应；(2)在三氟乙酸存在下，将2-氨基苯并咪唑与蒽酰氨或酯反应；(3)将2-甲基硫代苯并咪唑与蒽酰卤化物水合物反应。
• Process for making phenoxycycloalkanols
  申请人：Uniroyal Chemical Company, Inc.

  公开号：US04754076A1

  公开（公告）日：1988-06-28

  A process for producing a phenoxycycloalkanol comprising reacting an aromatic alcohol with an (optionally substituted) C.sub.5 -C.sub.6 cycloalk-1,2-ylene oxide in the presence of an effective amount of a sodium-containing catalyst selected from the group consisting of sodium metal, C.sub.1 -C.sub.8 sodium alkoxide, C.sub.6 -C.sub.10 sodium aryloxide, C.sub.7 -C.sub.9 sodium alkaryloxide and sodium hydride at between about 170.degree. C. and about 225.degree. C.

  一种生产苯氧基环烷醇的方法，包括在存在有效量的钠催化剂的情况下，将芳香醇与（可选取代的）C.sub.5-C.sub.6环烷-1,2-亚氧化物反应，所述钠催化剂选自以下组中的一种：钠金属，C.sub.1-C.sub.8钠烷氧基，C.sub.6-C.sub.10钠芳氧基，C.sub.7-C.sub.9钠烷芳氧基和氢化钠，在约170℃至约225℃之间进行。
• SEROTONIN RECEPTOR MODULATOR
  申请人：Janssen Pharmaceutica NV

  公开号：US20140038943A1

  公开（公告）日：2014-02-06

  Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

  某些二苯基化合物是有效的血清素调节剂，可用于治疗血清素介导的疾病。
• TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS
  申请人：Forma Therapeutics, Inc.

  公开号：US20150232445A1

  公开（公告）日：2015-08-20

  The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R 1 , R 2 , R 5 , and R 8 are as described herein.

  本发明涉及抑制溴和额外末端（BET）溴域的抑制剂，其可用于治疗癌症、炎症性疾病、糖尿病和肥胖症，其化学式为I：其中W、X、Y、Z、R1、R2、R5和R8如本文所述。