4-Methyl-2-oxo-2H-1-benzopyran-7-yl I(2)-D-galactopyranosiduronic acid | 6160-81-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-Methyl-2-oxo-2H-1-benzopyran-7-yl I(2)-D-galactopyranosiduronic acid
• 英文别名: (2S,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxane-2-carboxylic acid
• CAS: 6160-81-2
• 化学式: C₁₆H₁₆O₉
• 分子量: 352.298
• InChiKey: ARQXEQLMMNGFDU-SQCNAZHOSA-N

物化性质

• 熔点：
  142-144 °C
• 沸点：
  683.1±55.0 °C(Predicted)
• 密度：
  1.632±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  sodium 4-methylumbelliferonate 在 甲醇 、 lithium hydroxide 、 sodium hydroxide 、 苄基三乙基氯化铵 、 sodium methylate 作用下， 以 四氢呋喃 、 氯仿 、 水 为溶剂， 反应 7.0h， 生成 4-Methyl-2-oxo-2H-1-benzopyran-7-yl I(2)-D-galactopyranosiduronic acid
  参考文献：
  名称：

  Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails

  摘要：

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.

  DOI：

  10.1021/ol062889f

文献信息

• Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails
  作者：Sungjin Park、Injae Shin

  DOI：10.1021/ol062889f

  日期：2007.2.1

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.